The effect of allopurinol on the steady‐state pharmacokinetics of indomethacin.

Abstract

The effect of 5 days treatment with allopurinol (300mg) on the pharmacokinetics of indomethacin at steady-state was investigated in eight patients. Allopurinol produced no significant effect on the indomethacin serum concentration-time curve. Allopurinol did not alter significantly the amounts of indomethacin excreted in the urine within 8 h. However, the urinary ratio of N-deschlorobenzoylindomethacin to indomethacin was reduced significantly by allopurinol administration (P < 0.05).

The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes.

“…After oral administration of 200 mg AZT, peak plasma concentrations are approximately 4-5 FM (Taburet et al, 1990). Peak concentrations of naproxen and indomethacin will be higher after conventional dosage regimens (350 FM after 500 mg and 8 FM after 50 mg twice and three times daily (Van Den Ouweland et al, 1987;Pullar et al, 1988). Although these in vivo plasma concentrations are somewhat less than the concentrations used in the in vitro system, they indicate that naproxen and indomethacin will be in excess of AZT.…”