The effect of alpha-cyclodextrin on postprandial glucose excursions, a systematic meta analysis <i>Alpha-cyclodextrin and Blood Glucose</i>

Wittkowski, Knut M.

doi:10.1101/2022.09.04.22279468

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…A previous version of this article was posted to the medRxiv preprint server on September 6, 2022 [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Alpha-Cyclodextrin on Postprandial Glucose Excursions: a Systematic Meta-Analysis

Wittkowski¹

2022

Cureus

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Alpha-cyclodextrin (αCD) is a bacterial product that is widely used as a food ingredient. In the European Union (EU), αCD is regulated as a dietary fiber with an authorized health claim “for contributing to the reduction of postprandial glycemic responses.” In the US, αCD is generally recognized as save (GRAS), but on April 25, 2022, the U.S. Food and Drug Administration (FDA) rejected the inclusion of αCD in the list of dietary fibers because “the strength of the scientific evidence does not support a finding of a beneficial effect of αCD on postprandial blood glucose …” To evaluate the strength of this scientific evidence, this meta-analysis reviews clinical trials conducted to test the effect of αCD on the rise of blood glucose and insulin levels during three hours after consumption of a meal comprising carbohydrates, fats, and proteins. Several issues related to the standardization of the outcomes, the choice of the statistical methods in the cross-over studies conducted, and the choice of methods for the aggregation of P-values are discussed. It is concluded that the administration of αCD not only reduces the postprandial glycemic responses, but the absence of an increase in insulin levels suggests that αCD acts independently of increasing insulin production and, thus, the beneficial effect of αCD is not affected by insulin resistance.

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“…A previous version of this article was posted to the medRxiv preprint server on September 6, 2022 [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Alpha-Cyclodextrin on Postprandial Glucose Excursions: a Systematic Meta-Analysis

Wittkowski¹

2022

Cureus

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The effect of alpha-cyclodextrin on postprandial glucose excursions, a systematic meta analysis Alpha-cyclodextrin and Blood Glucose

Wittkowski¹

2022

Preprint

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Alpha-cyclodextrin (αCD) is a bacterial product that is widely used as a food ingredient. In the EU, αCD is regulated as a "dietary fiber" with an authorized health claim that it contributes to the reduction of post-prandial glycemic responses. In the US αCD is GRAS (generally recognized as save), but the FDA recently rejected the inclusion of αCD in the list of "dietary fibers", because "the strength of the scientific evidence does not support a finding of a beneficial effect of αCD on postprandial blood glucose ...". The meta-analysis presented here provides a review of studies conducted on the effect of αCD on the rise of blood glucose levels after consumption of ~50 g of starch.

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The effect of alpha-cyclodextrin on postprandial glucose excursions, a systematic meta analysis Alpha-cyclodextrin and Blood Glucose

Cited by 2 publications

References 24 publications

The Effect of Alpha-Cyclodextrin on Postprandial Glucose Excursions: a Systematic Meta-Analysis

The Effect of Alpha-Cyclodextrin on Postprandial Glucose Excursions: a Systematic Meta-Analysis

The effect of alpha-cyclodextrin on postprandial glucose excursions, a systematic meta analysis Alpha-cyclodextrin and Blood Glucose

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