The EFFECT OF ALPHA-MANGOSTIN IN BALANCING THE RATIO OF CYTOKINES PRO-AND ANTI-INFLAMMATION-GAMMA (IFN-γ/IL-10) AND SEVERITY OF THE DISEASE IN MICE INFECTED WITH MYCOBACTERIUM TUBERCULOSIS MULTIDRUG-RESISTANT

Nugrahaeni, Dyan Kunthi; Hadisaputro, Suharyo; Suwondo, Ari; Dharmana, Edi

doi:10.22159/ajpcr.2016.v9s3.14544

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…In 2017, 87% of new TB cases occurred in 30 countries and >95% cases of TB-infected individuals in developing countries such as India, China, Indonesia, the Philippines, Pakistan, Nigeria, Bangladesh, and South Africa [2]. Indonesia, with 842,000 cases, is the third country with the highest number of cases of TB worldwide after India and China [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Identification of Drug-Related Problems in Adults With Tuberculosis at the Tebet Subdistrict Health Center From July to December 2018

Puspitasari¹,

Yunaz

Nadhilah³

2020

Int J App Pharm

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Objective: Tuberculosis (TB) is a highly prevalent infectious disease caused by Mycobacterium tuberculosis. The recommended TB treatment is acombination of various antibiotics in the form of a fixed-dose combination tablet or kombipak; however, this increases the prevalence of drug-relatedproblems. Therefore, this study aimed to identify drug-related problems of patients receiving TB therapy at the Tebet Subdistrict Health Center fromJuly 2018 to December 2018.Methods: The study was designed as a cross-sectional study using the retrospective data retrieval method from prescriptions of patients withTB from July 2018 to December 2018. The classification system prepared by Cipolle, Strand, and Morley was used for the classification of drugrelatedproblems; this system includes unnecessary drug therapy, required additional drug therapy, ineffective drug, dosage error, and druginteraction.Results: The percentage of unnecessary drug therapy, required additional drug therapy, ineffective drug, dosage error, and drug interaction was2.85%, 6.89%, 1.54%, 12.46%, and 66.18%, respectively, with the occurrence of drug-related problems being the highest.Conclusion: The administration of anti-TB drugs can potentially cause drug-related problems. Therefore, the assessment needs to be optimizedbefore the administration of medications to patients and medications should be prescribed and monitored regularly to achieve rational drug use

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Section: Introductionmentioning

confidence: 99%

“…The compliance with medication intake in patients infected with TB and with other diseases is challenging, leading to multidrug-or rifampicin-resistant (RR) TB (Multidrug resistance [MDR]/RR-TB) [4,5]. Some reasons for this include failure in dose use, indiscipline, and drug interaction with other medicines [6].…”

Section: Introductionmentioning

confidence: 99%

Identification of Drug-Related Problems in Adults With Tuberculosis at the Tebet Subdistrict Health Center From July to December 2018

Puspitasari¹,

Yunaz

Nadhilah³

2020

Int J App Pharm

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“…The extract from the fruit rind of mangosteen (Garcinia mangostana) which belongs to family Guttiferae, is popularly added in cosmetics and pharmaceutical products for various effects due to the antioxidant, anti-inflammatory, and antimicrobial properties of the extract [1][2][3]. The bioactive components found in the extract are tannins and xanthones, mainly α-mangostin [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization and Antioxidant Activity of Xanthone-Loaded Making (Hodgsonia Heteroclita) Microemulsions

Chansakaow

Sirisa-ard

Khonkarn

2017

Int J Pharm Pharm Sci

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Objective: The aim of this study was to incorporate xanthone into Making (Hodgsonia heteroclita) microemulsions and to evaluate the antioxidant activity of the formulations. Methods:Making oil was obtained from the seed of Hodgsonia heteroclite by a screw press machine. The solubility of xanthone in various oils, surfactants, and co-surfactants was investigated. Stable Making microemulsion and microemulsion-based gel were simultaneously loaded with xanthone. Finally, an in vitro xanthone release study was carried out and antioxidant activity was determined. Results:The optimal formulations of the Making microemulsion consisted of Making oil, capryol 90, tween 80, propylene glycol, and water. The average droplet size of xanthone-loaded Making microemulsion was around 110-130 nm. It was found that the stability of the xanthone-loaded Making microemulsion-based gel was higher than the xanthone-loaded Making microemulsion. Besides, the release of xanthone from the Making microemulsion-based gel was lower than that of the Making microemulsion. Moreover, it was found that the antioxidant activity of both xanthoneloaded Making microemulsion (TEAC and EC values of 9.8 mmol/mg and 14.8 mmol/mg, respectively) and microemulsion-based gel (TEAC and EC values of 9.4 mmol/mg and 18.5 mmol/mg, respectively) remained high even after extended storage conditions. Conclusion:It was concluded that Making oil is an attractive material to deliver xanthone in pharmaceutical applications.

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A Mechanistic Review on Protective Effects of Mangosteen and its Xanthones Against Hazardous Materials and Toxins

Yahyazadeh,

Rahimi,

Yahyazadeh

et al. 2024

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Due to its pharmacological properties, α-Mangostin, mainly found in Garcinia mangostana (G.mangostana) L. (Mangosteen, queen of fruits), treats wounds, skin infections, and many other disorders. In fact, α-Mangostin and other xanthonoid, including β-Mangostin and γ-Mangostin, are found in G. mangostana, which have various advantages, namely neuroprotective, anti-proliferative, antinociceptive, antioxidant, pro-apoptotic, anti-obesity, anti-inflammatory, and hypoglycemic through multiple signaling mechanisms, for instance, extracellular signal-regulated kinase1/2 (ERK 1/2), mitogen-activated Protein kinase (MAPK), nuclear factor-kappa B (NF-kB), transforming growth factor beta1 (TGF-β1) and AMP-activated protein kinase (AMPK). This review presents comprehensive information on Mangosteen’s pharmacological and antitoxic aspects and its xanthones against various natural and chemical toxins. Because of the insufficient clinical study, we hope the current research can benefit from performing clinical and preclinical studies against different toxic agents.

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The EFFECT OF ALPHA-MANGOSTIN IN BALANCING THE RATIO OF CYTOKINES PRO-AND ANTI-INFLAMMATION-GAMMA (IFN-γ/IL-10) AND SEVERITY OF THE DISEASE IN MICE INFECTED WITH MYCOBACTERIUM TUBERCULOSIS MULTIDRUG-RESISTANT

Cited by 4 publications

References 25 publications

Identification of Drug-Related Problems in Adults With Tuberculosis at the Tebet Subdistrict Health Center From July to December 2018

Identification of Drug-Related Problems in Adults With Tuberculosis at the Tebet Subdistrict Health Center From July to December 2018

Preparation, Characterization and Antioxidant Activity of Xanthone-Loaded Making (Hodgsonia Heteroclita) Microemulsions

A Mechanistic Review on Protective Effects of Mangosteen and its Xanthones Against Hazardous Materials and Toxins

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