Pasien skizofrenia yang menggunakan terapi obat kombinasi antidepresan dalam pengobatannya dapat menimbulkan interaksi obat. Penelitian ini bertujuan untuk mengetahui potensi interaksi obat golongan antidepresan pada pasien skizofrenia. Desain penelitian ini menggunakan cross sectional. Data yang digunakan adalah data sekunder dari resep dan rekam medis pasien skizofrenia rawat jalan di RSJ Dr. Soeharto Heerdjan tahun 2016 dengan metode retrospektif. Pengambilan sampel dilakukan secara acak. Data sampel yang dianalisis sebanyak 743 lembar resep dan sebanyak 694 (91,41%) lembar resep terdapat interaksi obat dengan jumlah kasus interaksi sebanyak 1286 kasus (61,24%). Jenis interaksi obat yang paling banyak ditemukan adalah fluoksetin dan risperidon sebanyak 376 kasus (29,24%). Tingkat keparahan interaksi mayor sebanyak 1246 kasus (96,89%), moderat sebanyak 34 kasus (2,64%) dan minor sebanyak 6 kasus (0,47%). Tingginya kejadian interaksi obat pada peresepan antidepresan memerlukan pemantauan yang ketat, dan bila perlu dimodifikasi ketika dampak negatif yang ditimbulkan lebih besar daripada dampak positif.

Objective: Acute respiratory tract infection (ARTI) is common and has the highest death rate in children, especially in growing countries such asIndonesia. The aim of the research is to identify drug-related problems (DRPs) in pediatric ARTI patients based on the DRP classification by Cipolle,Strand, and Morley, which included categories such as unnecessary drug therapy, need additional therapy, ineffective drug, dosage adjustments suchas too low or too high, and adverse drug reaction which is drug interaction.Methods: The design of the study was cross-sectional and descriptive with a retrospective method. The sample of the study was the overall prescriptionsto upper respiratory tract infection patients in Tebet Subdistrict Health Center from July to December 2018 that fulfilled all of the inclusion criteria,using the total sampling method. Total samples that were analyzed were from 179 sheets of prescription with a total of 498 prescriptions.Results: The results of the research based on each parameter were inaccurate drug selection (9.5%), inaccurate indication (12.8%), mismatched dose(79.9%), and drug interaction (0.6%).Conclusion: DRPs in ARTI pediatric patients resulted in a high-risk condition so that the health facilities need to improve their prescribing pattern andmonitor and manage each therapy as well as do a routine prescription assessment to minimize the incidence of DRPs and achieve a rational drug usage.

Objectives: Hypertension is a common disease around the world. Depending on the severity or the presence of other diseases, whether related or unrelated, additional drug therapy may be required to optimize treatment and to reduce the side effects of drugs. The use of drugs in large amounts may increase the risk of drug interactions. The purpose of this research was to evaluate the characteristics of hypertension patients, prescriptions, and potential drug interactions in hypertensive patients in the Sukmajaya Community Health Center from June to November 2015.Methods: This research used a descriptive analytic method and the data were retrospectively obtained. Results:The results were based on the analysis of 350 prescriptions of female (67.43%) and male (32.57%) patients, with the highest prevalence of hypertension occurring at the age of ≥55 years. Potential drug interactions were analyzed using Micromedex. The most frequent potential interaction resulted from the combined use of captopril and non-steroidal anti-inflammatory drugs. The most frequent mechanism of drug interaction was pharmacokinetics (51.06%). The chi-square test results showed a significant relationship between the number of prescribed drugs and potential interactions at a probability value of 0.0001 and an odds ratio of 5.940 (15.588-2.263). Conclusions:With respect to interaction mechanism, pharmacokinetic (51.06%) was the most frequent and 61.70% of potential cases involved a moderate interaction risk.

Objective: This study aimed to monitor the side effects of patients who received antiretroviral medications in a subdistrict of West Jakarta in 2017.Methods: Descriptive research was performed using data collected prospectively from patients who met our inclusion criteria (total sampling).Primary data were obtained from interviews, and secondary data were obtained from medical and prescription records. The Naranjo algorithm wasused to classify side effects.Results: The side effects experienced by patients in this study fell into probable (45.45%) and possible (36.36%) categories. However, age (p=0.379),gender (p=1), and length of treatment (p=0.07) did not significantly affect the occurrence of side effects.Conclusion: Monitoring the side effects of antiretroviral medicine is necessary to prevent serious and rare side effects. The occurrence of side effects,whether they have an established causal relationship or not, could be prevented by appropriate monitoring.

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