Monitoring Side Effects of Antiretroviral Therapy in Patients With Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Sari, Santi Purna; Isnaini, Siti Rizky; Puspitasari, Atika Wahyu

doi:10.22159/ijap.2018.v10s1.71

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…Sedangkan efek samping yang muncul setelah durasi lebih dari 6 bulan karena terdapat akumulasi toksik akibat penggunaan jangka panjang dari ARV. 21,22 Namun, dalam penelitian ini terdapat beberapa keterbatasan. Pertama, tidak dapat menjelaskan hubungan sebab-akibat antara efek samping yang timbul dengan riwayat penggunaan ARV.…”

Section: Efek Sampingunclassified

Profil Efek Samping Penggunaan Antiretroviral Pada Penderita Hiv/Aids Di Poliklinik VCT Di Kota Mataram Tahun 2019

Pertiwi

Wardani²,

Wedayani³

2021

JKU

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Latar Belakang: Di Indonesia, upaya penanganan infeksi HIV menerapkan pendekatan fast track 90-90-90, dengan satu indikatornya yaitu pemberian ARV pada penderita HIV. ARV lini pertama yang digunakan di Indonesia saat ini yaitu tenofovir, lamivudine/emtricitabine, dan efavirenz dalam bentuk kombinasi dosis tetap (KDT). Namun, penggunaan ARV dapat menimbulkan efek samping dari reaksi ringan hingga berat. Penelitian ini bertujuan untuk mengetahui efek samping yang ditimbulkan ARV pada penderita HIV/AIDS di Poliklinik VCT di Kota Mataram tahun 2019. Metode: Penelitian ini merupakan studi deskriptif kuantitatif yang di lakukan di Poliklinik VCT di Kota Mataram. Subjek penelitian adalah pasien HIV di Poliklinik VCT di Kota Mataram yang memenuhi kriteria inklusi dan eksklusi. Data berupa data sekunder yang bersumber dari rekam medik pasien. Hasil: Subjek penelitian berjumlah 27 orang. Efek samping terjadi pada 8 orang (29,6%). Kejadian efek samping terjadi pada 7 orang yang menggunakan atripla dengan kejadian paling banyak adalah lemas, pusing, muntah, SGOT dan SGPT meningkat. Sedangkan 1 orang pengguna duviral/neviral mengeluhkan mual, muntah, dan gatal. Efek samping yang muncul 100% derajat 1 dari toksisitas obat. Kesimpulan: Efek samping yang paling sering muncul yaitu muntah, lemas, pusing, SGOT dan SGPT meningkat Semua kejadian efek samping merupakan reaksi ringan (derajat 1) sehingga pemberian terapi tetap dilanjutkan dan tidak diperlukan pertimbangan pergantian terapi. Kata kunci : Infeksi HIV, ARV, Atripla, duviral/neviral, efek samping, derajat 1

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Section: Efek Sampingunclassified

Profil Efek Samping Penggunaan Antiretroviral Pada Penderita Hiv/Aids Di Poliklinik VCT Di Kota Mataram Tahun 2019

Pertiwi

Wardani²,

Wedayani³

2021

JKU

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“…(2018) yang menyatakan bahwa pada pasien HIV, jenis kelamin laki-laki lebih banyak dibandingkan perempuan yaitu sebesar 69,2% yang berasal dari kelompok gay, biseksual, dan transgender. Hal ini juga dikaitkan laki-laki lebih berisiko tinggi terlibat pada hubungan homoseksual, heteroseksual, dan penggunaan jarum suntik non-steril (Sari et al, 2018). Dalam penelitian ini didapatkan data bahwa usia pasien HIV rawat jalan berada dalam usia produktif dengan dengan usia rata-rata 29,9 ± 8,9 tahun.…”

Section: Hasil Dan Pembahasanunclassified

A cross sectional survey of side effects of antiretroviral (ARV) in outpatients HIV by Naranjo Algorithm

Putra

2021

JIF

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Background: The main modality in HIV patients is the administration of long-treatment antiretroviral therapy (ARV). One of the problems from the use of ARV therapy is the side effects that can reduce patient compliance in taking medication, which has the potential to cause treatment failure. Objective: This study aims to examine the side effects and their causality in the use of ARVs in outpatient HIV patients at the VCT Clinic, Bhayangkara H.S. Hospital. Samsoeri Mertojoso Surabaya. Methods: This research was a prospective observational study with a cross-sectional design. Side effect data were taken from HIV patients by interview using the Naranjo algorithm. HIV patients who met the inclusion criteria were included in the study sample using consecutive sampling. This research was conducted from January to March 2020. Results: There were 72 outpatient HIV patients who met the inclusion criteria. The most opportunistic infections found in HIV patients are tuberculosis and Pneumocystis pneumonia. The results showed that the most common side effects experienced by patients were dizziness (43%), nausea and vomiting (31%), and rash (11%) with the highest Naranjo score being in the probable category of 86%. The Naranjo score in HIV patients with opportunistic infections and with comorbidities was significantly smaller than those in HIV patients without opportunistic infections or without comorbidities with independent t-test (P <0.05). Conclusion: The side effects in HIV patients while undergoing treatment with antiretroviral therapy are classified as a minor side effect and the cause of the side effects that occur is thought to be due to the probable category of ARV therapy. Keywords: HIV Patients, Antiretroviral, Side Effects, Naranjo's Algorithm.

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“…This suggests that the 20m sample has better antiretroviral activity when compared to that of lamivudine, and also, it has capabilities that are not much different from those of standard antiretroviral drugs available on the market. The potential of antiretroviral from natural product medicine must be monitored its side effects by appropriate monitoring [31].…”

Section: Antiretroviral Activity Test Using Srv-2mentioning

confidence: 99%

Isolation of Protein From the Spine Venom of Pterois Volitans Found in the Indonesian Ocean, Using a Heating Process, for Anticancer, Antiretroviral, Antibacterial, and Antioxidant Assays

Ibrahim¹,

Sahlan²,

Ginting

et al. 2021

Int J App Pharm

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Objective: This research investigates the antibacterial, anticancer, antioxidant, and antiretroviral activities of the lionfish spine poison extract. Methods: Isolation and purification of the phospholipase A2 (PLA2) protein obtained from the spine poison were conducted through the following stages, including, extraction of the venom by sonication, heating, and purification using gradual saturation levels of ammonium sulfate. Furthermore, the purity and concentration of PLA2 were analyzed using the Lowry test and Marinetti’s method, respectively, while its protein content was ascertained through SDS-PAGE. Toxicity was then evaluated employing the brine shrimp lethality test (BSLT), and its anticancer activity was assessed in human cervical carcinoma cells (HeLa cells). Finally, its antioxidant, antibacterial, and antiretroviral activities were analyzed using the DPPH method, agar diffusion test against Salmonella sp. and E. coli, and SRV-2 and RT-qPCR tests, respectively. Results: The protein demonstrated 37.79% inhibition for anticancer activity, IC50 1312 ppm for antioxidant activity, 98.81%, and 89.28% inhibition of E. coli and Salmonella sp. respectively for antibacterial activity and 98.13% inhibition for antiretroviral activity. Conclusion: It can be concluded that lionfish (Pterois volitans) has the potential to be developed as an antioxidant, anticancer, antibacterial, and antiretroviral agent. Furthermore, the pharmacological activity of its spine venom was determined by isolating PLA2 protein from its extract, using an optimum heating temperature of 70 °C and an ammonium sulfate saturation level of 80%.

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Monitoring Side Effects of Antiretroviral Therapy in Patients With Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Cited by 4 publications

References 8 publications

Profil Efek Samping Penggunaan Antiretroviral Pada Penderita Hiv/Aids Di Poliklinik VCT Di Kota Mataram Tahun 2019

Profil Efek Samping Penggunaan Antiretroviral Pada Penderita Hiv/Aids Di Poliklinik VCT Di Kota Mataram Tahun 2019

A cross sectional survey of side effects of antiretroviral (ARV) in outpatients HIV by Naranjo Algorithm

Isolation of Protein From the Spine Venom of Pterois Volitans Found in the Indonesian Ocean, Using a Heating Process, for Anticancer, Antiretroviral, Antibacterial, and Antioxidant Assays

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