The Effect of an Angiotensin Converting Enzyme Inhibitor on Intestinal Wound Healing

Ilhan, Yavuz Selim; Bülbüller, Nurullah; Kırkıl, Cüneyt; Ozercan, Resat; Seçkin, Dilara

doi:10.1016/j.jss.2005.03.001

Cited by 14 publications

(10 citation statements)

References 19 publications

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“…Of note, the breaking strength of the fistula is regularly thought to be a direct reflection of the successful repair process (13,14,56). The increase of breaking strength essentially exemplifies the advanced healing process and shows the efficiency of the applied therapy (13,14,56). Namely, colocutaneous fistulas spontaneously heal unless complicated (1).…”

Section: Discussionmentioning

confidence: 99%

Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System

et al. 2008

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Abstract. We focused on the therapeutic effect of the stable gastric pentadecapeptide BPC 157 and how its action is related to nitric oxide (NO) in persistent colocutaneous fistula in rats (at 5 cm from anus, colon defect of 5 mm, skin defect of 5 mm); this peptide has been shown to be safe in clinical trials for inflammatory bowel disease (PL14736) and safe for intestinal anstomosis therapy. BPC 157 (10 μg / kg, 10 ng / kg) was applied i) in drinking water until the animals were sacrificed at post-operative day 1, 3, 5, 7, 14, 21, and 28; or ii) once daily intraperitoneally (first application 30 min following surgery, last 24 h before sacrifice) alone or with N G -nitro-L-arginine methyl ester (L-NAME) (5 mg / kg), L-arginine (200 mg/ kg), and their combinations. Sulphasalazine (50 mg / kg) and 6-α-methylprednisolone (1 mg / kg) were given once daily intraperitoneally. BPC 157 accelerated parenterally or perorally the healing of colonic and skin defect, leading to the suitable closure of the fistula, macro / microscopically, biomechanically, and functionally (larger water volume sustained without fistula leaking). L-NAME aggravated the healing failure of colocutaneous fistulas, skin, and colon wounds (L-NAME groups). L-Arginine was effective only with blunted NO generation (L-NAME + L-arginine groups) but not without (L-arginine groups). All of the BPC 157 beneficial effects remained unchanged with blunted NO-generation (L-NAME + BPC 157 groups) and with NO substrate (L-arginine + BPC 157 groups) as well as L-NAME and L-arginine co-administration (L-NAME + L-arginine + BPC 157 groups). Sulphasalazine was only moderately effective, and corticosteroid even had an aggravating effect.

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Section: Discussionmentioning

confidence: 99%

Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System

et al. 2008

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“…As a result, increasing the anastomotic strength is considered to be an essential healing point. 1 Therefore, the capability to heal dehiscence of intestinal anastomosis could be particularly important for improving infl ammatory bowel disease therapy. 8,9 Since the early postoperative period, controls present the intestinal leakage with low tensile strength which fails to heal without therapy.…”

Section: Discussionmentioning

confidence: 99%

Stable Gastric Pentadecapeptide BPC 157 in Trials for Inflammatory Bowel Disease (PL-10, PLD-116, PL14736, Pliva, Croatia) Heals Ileoileal Anastomosis in the Rat

et al. 2007

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“…29,30 Consequently, ACE inhibitors have been evaluated regarding whether or not they pose a risk to wound healing. 22,31 Ilhan et al demonstrated that lisinopril, initiated 12 h before operation, impaired intestinal wound healing in a dose dependent manner. 31 In conclusion, we observed that untreated hypertension had no effect on the abdominal wall healing of rats.…”

Section: Discussionmentioning

confidence: 99%

“…22,31 Ilhan et al demonstrated that lisinopril, initiated 12 h before operation, impaired intestinal wound healing in a dose dependent manner. 31 In conclusion, we observed that untreated hypertension had no effect on the abdominal wall healing of rats. In addition, enalapril signifi cantly reduced the systolic blood pressure and cardiac hypertrophy of SHR.…”

Section: Discussionmentioning

confidence: 99%

Effects of Hypertension on Abdominal Wall Healing: Experimental Study in Rats

Tostes

Watanabe

2007

Surg Today

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The Effect of an Angiotensin Converting Enzyme Inhibitor on Intestinal Wound Healing

Cited by 14 publications

References 19 publications

Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System

Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System

Stable Gastric Pentadecapeptide BPC 157 in Trials for Inflammatory Bowel Disease (PL-10, PLD-116, PL14736, Pliva, Croatia) Heals Ileoileal Anastomosis in the Rat

Effects of Hypertension on Abdominal Wall Healing: Experimental Study in Rats

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