The effect of an intrauterine device on mast cell numbers and distribution in the hamster uterus

Mast cells (MCs) are widely distributed in most human tissues. Those cells that contain only tryptase are designated as T-MCs, while those that also contain chymase are referred to as TC-MCs. This study uses immunohistochemical staining for tryptase and chymase to assess the distribution and heterogeneity of these two types of MCs in the human uterus. The greatest number of MCs was found in the inner (i.e. luminal) half of the myometrium, with this area containing approximately equal proportions of T-MCs and TC-MCs. There were fewer MCs in the outer half of the myometrium and the cervix, but the proportion of TC-MCs in both of these areas was substantially higher. In contrast, the endometrium contained significantly fewer MCs, but proportionally more T-MCs. There was no change in the number of MCs between the proliferative and secretory phases of the menstrual cycle; however, there was a significantly lower number in all areas after menopause. Most of the MCs were observed in close association with uterine smooth muscle cells, as well as in the vicinity of fibroblasts and collagen, and it appears they may play an important role in the reconstruction of uterine tissues during the menstrual cycle.

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Distribution and heterogeneity of mast cells in the human uterus

Mori

Zhai

Toki

et al. 1997

Human Reproduction

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Mast cells in the tubal wall in women using an intrauterine contraceptive device

Sandvei

Wollen

Flood

et al. 1986

BJOG

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Summary. The number of mast cells in the tubal wall of 33 healthy non‐pregnant women, 17 of whom had an intrauterine contraceptive device (IUCD), was investigated. Light microscopy showed that both the muscularis externa and the lamina propria of the tubal wall contained more mast cells in the 17 IUCD users than in the 16 non‐users (control group). In both patient groups the mast cell concentration was higher in the muscularis externa than in the lamina propria. Most mast cells of the muscularis externa were more closely related to smooth muscle cells than to blood vessels. The increased number of mast cells in IUCD users may be a factor in the pathogenesis of pelvic inflammatory disease and the ectopic pregnancies that occur in IUCD users.

show abstract

Mast cells in the tubal wall in women using an intrauterine contraceptive device

Sandvei

Wollen

Flood

et al. 1986

BJOG

View full text Add to dashboard Cite

The number of mast cells in the tubal wall of 33 healthy nonpregnant women, 17 of whom had an intrauterine contraceptive device (IUCD), was investigated. Light microscopy showed that both the muscularis externa and the lamina propria of the tubal wall contained more mast cells in the 17 IUCD users than in the 16 non-users (control group). In both patient groups the mast cell concentration was higher in the muscularis externa than in the lamina propria. Most mast cells of the muscularis externa were more closely related t o smooth muscle cells than to blood vessels. T h e increased number of mast cells in IUCD users may b e a factor in the pathogenesis of pelvic inflammatory disease and the ectopic pregnancies that occur in IUCD users.

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The effect of an intrauterine device on mast cell numbers and distribution in the hamster uterus

Cited by 3 publications

References 24 publications

Distribution and heterogeneity of mast cells in the human uterus

Distribution and heterogeneity of mast cells in the human uterus

Mast cells in the tubal wall in women using an intrauterine contraceptive device

Mast cells in the tubal wall in women using an intrauterine contraceptive device

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