The Effect of an SOD Derivative (SM-SOD) Administration in a Burned Rat Model.

Saitoh, Daizoh; Okada, Yoshiaki; Takahara, Takashi; Yamashita, Hitoshi; Ohno, Hideki; Inoue, Masayasu

doi:10.1620/tjem.174.31

Cited by 11 publications

(3 citation statements)

References 24 publications

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“…A second murine model involving full-thickness burn wounds assessed the ability of intravenous long-acting Cu/ Zn-SOD at a concentration of 10 mg/kg (poly butyl esterbound SOD) to affect plasma TBAR metabolite following prewound administration [15] . SOD-treated animals had significantly lower plasma TBAR metabolite levels 3 h after burn compared to control (saline-treated) animals.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

Fitzmaurice

Sivamani

Isseroff

2011

Skin Pharmacol Physiol

221

144

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Many facets of wound healing under redox control require a delicate balance between oxidative stress and antioxidants. While the normal physiology of wound healing depends on low levels of reactive oxygen species and oxidative stress, an overexposure to oxidative stress leads to impaired wound healing. Antioxidants are postulated to help control wound oxidative stress and thereby accelerate wound healing. Many antioxidants are available over the counter or by prescription, but only one, Medihoney®, has been specifically FDA approved for wound healing. Here we review the existing evidence for the use of antioxidants for wound healing, with a review of the pertinent animal and clinical studies. Natural products and naturally derived antioxidants are becoming more popular, and we specifically review the evidence for the use of naturally derived antioxidants in wound healing. Antioxidant therapy for wound healing is promising, but only few animal studies and even fewer clinical studies are available. Because only few products have undergone FDA approval, the consumer is advised to scrutinize them for purity and contaminants prior to use, and this may require direct contact with the companies that sell them. As a field of science, the use of antioxidants for wound healing is in its infancy, and future studies will better elucidate the role of antioxidants in wound healing.

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Section: Introductionmentioning

confidence: 99%

Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

Fitzmaurice

Sivamani

Isseroff

2011

Skin Pharmacol Physiol

221

144

View full text Add to dashboard Cite

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“…The therapeutic potential of the enzyme was also documented in burns. The prophylactic administration of SOD derivative inhibits the lipid peroxidation in the blood plasma and tissues, and increases the survival rate in the injured group (Saitoh et al 1994).…”

Section: Discussionmentioning

confidence: 99%

Effect of melatonin on the gastric antioxidant defence in experimental burn trauma

Hristova¹,

Tasinov²,

Tzaneva³

et al. 2022

Vet. Med. - Czech

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Severe burn trauma triggers oxidative gastric mucosal injury. The purpose of this study was to investigate the antioxidant defence mechanisms and protective effect of melatonin in the gastric mucosa after burn injury. In order to investigate the mechanisms involved in the gastric antioxidant defence in a rat burn model, quantitative real-time PCR and immunohistochemistry techniques were applied. An analysis of glutathione peroxidase 4 (GPx4), glutathione reductase (GR), and catalase (Cat) gene expression was performed along with the evaluation of the gastric Cu/Zn superoxide dismutase (Cu/Zn SOD) activity. Melatonin was applied immediately and 12 h after 30% of total body surface area burns. The burn injury significantly increased the Gpx4 mRNA (P < 0.000 1) and Gsr mRNA (P < 0.000 1) expression. It also had a slight positive effect on the Cat mRNA expression and Cu/Zn SOD activity. Melatonin, in turn, markedly augmented the burn-induced Cu/Zn SOD (P < 0.000 1) activity, reversed the Gpx4 mRNA (P < 0.000 1) and Gsr mRNA (P < 0.000 1) expression, and inhibited the Cat mRNA level. In conclusion, the present study suggests that a burn injury adaptively increases the Cu/Zn SOD activity and enhances the Gpx4 and Gsr gene expression in the gastric mucosa. Melatonin effectively modulates the expression of the cellular antioxidant enzymes, and improves the antioxidant defence by augmenting the Cu/Zn SOD activity.

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“…Their findings showed that SOD binds to styrene maleic acid and reduces the mortality, hemolysis, and the increase of vessel permeability during the early phase after burn injury. [40][41][42] The free radical scavenger, vitamin C, can also curtail the resuscitative volume required to treat up to 25% hypovolemia. 44 -46 Our data also imply that PC-SOD mitigates the amount of volume replacement required to resuscitate rats with imposed hypovolemia.…”

Section: Discussionmentioning

confidence: 99%

Lecithinized Superoxide Dismutase Suppresses Free Radical Substrates During the Early Phase of Burn Care in Rats

Koizumi

Goto

Tanaka

et al. 2009

Journal of Burn Care & Research

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Severe hypovolemia is caused by an increase in blood vessel permeability in the early phase after an extensive burn; massive fluid volume replacement has been used for the treatment of this condition. The release of oxygen free radicals and chemical mediators, especially from skin tissue, induces the increase in blood vessel permeability. Free radical burst is associated with ischemia-related skin tissue injury. Although various antioxidant therapies have been used to inhibit the consequences of hypovolemia, an effective method has not been established. To elucidate the protective effects of lecithinized superoxide dismutase (PC-SOD) as an antioxidant agent. Each rat sustained a 30% total body surface area burn (n = 20) on the back by the Walker and Mason method were allocated into three groups: (1) no treatment group (n = 6), (2) a low dose of PC-SOD (0.67 mg/kg) group (n = 7), and (3) a high dose of PC-SOD (1.33 mg/kg) group (n = 7). The concentrations of malondialdehyde and SOD in the serum, skin tissue, and lung tissue were measured in each group 1 hour after burning. Both low and high doses of PC-SOD prevented malondialdehyde concentration associated with free radical burst after burning compared with the no treatment group (P < .05); serum (27.7 +/- 6.8, 10.8 +/- 2.7, and 12.1 +/- 2.8 nmol/L), skin tissue (2251.3 +/- 560.5, 802.7 +/- 228.8, and 790.1 +/- 188.3 nmol/wet.g), and lung (157.3 +/- 19.5, 109.1 +/- 23.9, and 81.9 +/- 20.3 nmol/wet.g). These data suggest that PC-SOD may be a protective agent against free radical-induced vasodilatation caused by severe, extensive burns.

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The Effect of an SOD Derivative (SM-SOD) Administration in a Burned Rat Model.

Cited by 11 publications

References 24 publications

Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

Effect of melatonin on the gastric antioxidant defence in experimental burn trauma

Lecithinized Superoxide Dismutase Suppresses Free Radical Substrates During the Early Phase of Burn Care in Rats

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