The effect of anaemia and abnormalities of erythrocyte indices on HbA1c analysis: a systematic review

Abstract

Aims/hypothesis The use of HbA 1c for the diagnosis of diabetes is now widely advocated despite caveats to its use.

Impact of Iron And Vitamin B12 Anaemia At Glycosylated Hemoglobin Level: A Case Control Study

“…The hemoglobin and HbA 1c levels were positively correlated in anemia patients before treatment, but no positive correlation was apparent at 2 months after treatment. The authors did not discuss why their data conflicts with other studies but Emma English et al(2015) 9 in the review article postulated that it may be due to the severity of anemia as the participants in this study had low mean hemoglobin levels(62g/dl); the duration of anemia was not given. But in our study patients with severe anemia had significantly higher HbA 1c levels compared to patients with moderate anemia as well as controls.…”

The prevalence of type 2 diabetes mellitus in the adult population of Russia (NATION study)

“…Оценка уровня HbA 1c является относительно новым под-ходом в диагностике СД, который в настоящий момент не может рассматриваться как полностью стандартизи-рованный. Известно, что такие факторы, как анемия [22] или некоторые хронические заболевания [23], могут вли-ять на уровень HbA 1c . В некоторых исследованиях ука-зывается на то, что использование только уровня HbA 1c может привести к недодиагностике СД2 [24,25], а также, что этот показатель должен использоваться в сочетании с другими тестами для повышения достоверности поста-новки диагноза СД (например, оценка уровня глюкозы натощак [26]).…”

The effect of iron supplementation on HBA1c levels in non-diabetic pregnant women

“…At least half of this burden is assumed to be due to iron deficiency [3]. Although iron deficiency anemia is very common in pregnancy, to our best knowledge, there has been limited research investigating HBA1c levels in non-diabetic anaemic pregnant women and the effect of iron supplementation on HBA1c levels [4][5][6]. In order to see the effect of anemia treatment on HBA1c levels, we analysed HBA1c levels in non-diabetic pregnant women before and after iron supplementation.…”