The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients

Abstract

Colorectal cancer (CRC) is the key leading cause of high morbidity and mortality worldwide. Surgical excision is the most effective treatment for CRC. However, stress caused by surgery response can destroy the body's immunity and increase the likelihood of cancer dissemination and metastasis. Anesthesia is an effective way to control the stress response, and recent basic and clinical research has shown that anesthesia and related drugs can directly or indirectly affect the immune system of colorectal cancer patients during the perioperative period. Thus, these drugs may affect the prognosis of CRC surgery patients. This review is intended to summarize currently available data regarding the effects of anesthetics and related drugs on perioperative immune function and postoperative recurrence and metastasis in CRC patients. Determining the most suitable anesthesia for patients with CRC is of utmost importance.

Risk factors for postoperative meningitis after microsurgery for vestibular schwannoma

“…The mechanism may be that with prolonged operation time, the chance of external bacteria entering the cranium is increased, and the immune function of patients was inhibited under anesthesia. Dang, Y et al[20] claimed that anesthesia affected the number and activity of immune cells and the secretion of cytokines. Meninges and soft tissues are retracted for surgical exposure, resulting in reduced perfusion and time-dependent reduced local immunological defenses[21].…”

The effect of anesthesia on the postoperative systemic inflammatory response in patients undergoing surgery: A systematic review and meta-analysis

“…Experimental and clinical studies have long suggested that the choice of anesthetic agents may influence the immune system, in particular, that some anesthetic regimens may be associated with less immunosuppression. This is likely to be very important in cancer surgery [78] . With the enhanced recovery protocols now being used in cancer surgery there is an opportunity to move towards standardized anesthetic and perioperative care protocols that are known to reduce the magnitude of the postoperative systemic inflammatory response and therefore reduce the relative postoperative immunosuppression, with the aim of reducing postoperative morbidity, and disease recurrence in the context of cancer surgery.…”

Impact of Two Different Anesthetic Techniques on Immune Response and Postoperative Pain for Abdominal Hysterectomy

“…Yangjie Dang et al, [14] showed that compared to general anesthesia, regional anesthesia reduce the inhibition of immune function. Also Alan David Kaye et al, [15] advised to use regional analgesia than general anesthesia to avoid immune suppression, as the immunosuppressive effects of regional anesthesia may be less than the immunosuppressive effects of general anesthesia.…”