The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins.

Counts, Debra; Gwirtsman, H E; Carlsson, Lena; Lesem, Michael D.; Cutler, Gordon B.

doi:10.1210/jcem.75.3.1381372

Cited by 163 publications

(65 citation statements)

References 16 publications

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“…This differs from findings in individuals with anorexia nervosa, who have high IGFBP-2 levels and significantly reduced levels of total percentage fat and visceral adipose tissue (Krassas 2003;Counts et al 1992). This suggests that IGFBP-2 gene might be modulated in a depotspecific fashion.…”

Section: Igfbp-2 and Metabolismcontrasting

confidence: 74%

IGFBP-2 - taking the lead in growth, metabolism and cancer

Yau

Azar

Sabin

et al. 2015

J. Cell Commun. Signal.

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The activity of the Insulin-like Growth Factors (IGFs) ligands elicited via their receptors and transduced by various intracellular signal pathways is modulated by the IGF Binding Proteins (IGFBPs). Among all the IGFBPs, IGFBP-2 has been implicated in the regulation of IGF activity in most tissue and organs. Besides binding to IGFs in the circulation these IGF-regulatory activities of IGFBP-2 involve interactions with components of the extracellular matrix, cell surface proteoglycans and integrin receptors. In addition to these local peri-cellular activities, IGFBP-2 exerts other key functions within the nucleus, where IGFBP-2 directly or indirectly promotes transcriptional activation of specific genes. All of these IGFBP-2 activities, intrinsic or dependent on IGFs, contribute to its functional roles in growth/development, metabolism and malignancy as evidenced by studies in IGFBP-2 animal models and also by many in vitro studies. Finally, preclinical studies have demonstrated that IGFBP-2 administration can be beneficial in improving metabolic responses (inhibition of adipogenesis and enhanced insulin sensitivity), while blockade of IGFBP-2 appears to be an effective approach to inhibiting tumour growth and metastasis.

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Section: Igfbp-2 and Metabolismcontrasting

confidence: 74%

IGFBP-2 - taking the lead in growth, metabolism and cancer

Yau

Azar

Sabin

et al. 2015

J. Cell Commun. Signal.

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“…13,45,46 Prolonged fasting, as observed in patients with anorexia nervosa, and short-term fasting of normal-weight subjects, results in decreased IGF-I levels, 47,48 and there is a stepwise increment of IGF-I values related to weight gain in anorexic patients. 49 Short-term overfeeding of normalweight women also results in increased IGF-I levels. 50 In lean individuals, or after prolonged fasting, the comparatively low endogenous insulin production is associated with a reduction in GH receptor levels and resistance to the GH stimulation of IGF-I synthesis.…”

Section: Discussionmentioning

confidence: 99%

Body mass index, waist circumference and waist–hip ratio and serum levels of IGF-I and IGFBP-3 in European women

et al. 2006

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Objective: To examine the relationship between body mass index (BMI) and waist-hip ratio (WHR) with serum levels of insulinlike growth factor-I (IGF-I), and its binding protein (IGFBP)-3. Design: Cross-sectional study on 2139 women participating in a case-control study on breast cancer and endogenous hormones. Data on lifestyle and reproductive factors were collected by means of questionnaires. Body height, weight, waist and hip circumferences were measured. Serum levels of IGF-I and insulin-like binding protein (IGFBP)-3 were measured by enzymelinked immunosorbent assays. Adjusted mean levels of IGF-I and IGFBP-3 across quintiles of BMI, waist circumference, and WHR were calculated by linear regression. Results were adjusted for potential confounders associated with IGF-I and IGFBP-3. Results: Adjusted mean serum IGF-I values were lower in women with BMIo22.5 kg/m 2 or BMI429.2 kg/m 2 compared to women with BMI within this range (P heterogeneity o0.0001, P trend ¼ 0.35). Insulin-like growth factor-I was not related to WHR after adjustment for BMI. IGF-binding protein-3 was linearly positively related to waist and WHR after mutual adjustment. The molar ratio IGF-I/IGFBP-3 had a non-linear relation with BMI and a linear inverse relationship with WHR (P trend ¼ 0.005). Conclusions: Our data confirm the nonlinear relationship of circulating IGF-I to total adiposity in women. Serum IGFBP-3 was positively related to central adiposity. These suggest that bioavailable IGF-I levels could be lower in obese compared to nonobese women and inversely related to central adiposity.

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“…GHBP is known to be influenced by the nutritional state [16]. GHBP levels are high in obese children [16] and low in undernourished patients [10]. Overnutrition in obese children causes hyperinsulinemia.…”

Section: Discussionmentioning

confidence: 99%

“…IGFBPs are believed to modify IGF-I and -II action [7]. IGF-I and IGFBP-3 are known to be GH-dependent [8,9] and also to be nutritiondependent, since IGF-I and IGFBP-3 are increased by GH injection and decreased with dietary restriction in man [10,11]. IGFBP-1 is one of the IGFBPs which is mainly synthesized in the liver et al and is decreased by insulin [12].…”

mentioning

confidence: 99%

Nutrition Related Hormonal Changes in Obese Children.

et al. 1998

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Abstract. Children with simple obesity (SO) show increased linear growth with normal or high serum insulin-like growth factor-I (IGF-I) levels during prepubertal period, despite low GH secretion. We measured IGF-I, IGFBP-1, GHBP and other factors to clarify the hormonal relation between the nutrition and the linear growth in SO and compared these factors with children with normal short stature (NS). Subjects were 23 SO and 19 NS children, and their height standard deviation (SD) scores were 0.7 ± 0.2 SD and -3.4 ± 0.3 SD (mean ± SEM) (P<0.01), respectively. Oral glucose tolerance test (OGTT) was performed in all the subjects and GH-releasing factor (GRF) test was also performed in 13 of SO and 17 of NS. The peak levels of GH in the GRF test were significantly lower in SO than in NS (12.8 ± 1.7 vs. 39.8 ± 6.9 ng/ml) and showed a significantly positive correlation with IGFBP-1 (r= 0.63, P<0.01). Serum GHBP level and IGF-I level were significantly higher in SO than in NS on pubertal stage matching. There was a positive correlation between GHBP and insulin during OGTT (r=0.75, P<0.01). When the sum of the values during OGTT was expressed as L insulin, ~C-peptide and glucose were significantly higher in SO than in NS on pubertal stage matching. Basal and IGFBP-1 were significantly lower in SO than in NS, but IGFBP-3 levels showed no significant difference between the two groups either in prepuberty or midpuberty.In conclusion, it can be hypothesized that the overnutrition causes hyperinsulinemia which increases GH receptor and IGF-I secretion despite low GH secretion. Hyperinsulinemia also may increase free IGF-I by lowering IGFBP-1. These two mechanism are supposed to be the nutrition related hormonal changes in SO and can explain the growth of SO. In addition, the increased free IGF-I may contribute the decreased GH secretion due to negative feedback in SO.

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The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins.

Cited by 163 publications

References 16 publications

IGFBP-2 - taking the lead in growth, metabolism and cancer

IGFBP-2 - taking the lead in growth, metabolism and cancer

Body mass index, waist circumference and waist–hip ratio and serum levels of IGF-I and IGFBP-3 in European women

Nutrition Related Hormonal Changes in Obese Children.

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