The effect of antibiotic exposure on eicosanoid generation from arachidonic acid and gene expression in a primitive chordate,<i>Branchiostoma belcheri</i>

Yuan, Dongjuan; Pan, Minming; Zou, Qiuqiong; Chen, Shangwu; Xu, Anlong

doi:10.1016/j.fob.2015.07.004

Cited by 4 publications

(6 citation statements)

References 39 publications

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“…A multitude of ARA studies revealed decreased EPA deposition in fish in response to increasing dietary ARA levels. 17,20,22,73,[82][83][84]86,92,[94][95][96][97][98]104,105,[108][109][110][111][112][113][114]116,121,125,135,136,139,140,151,163,172,176,209,210 Therefore, no doubts should be present that increased dietary ARA displaces EPA retention in fish tissues.…”

Section: Interaction Between Ara and Other Lc-pufamentioning

confidence: 99%

“…First, a direct competition between ARA and EPA is present when they are incorporated into fish tissues, especially when incorporated into phospholipids and cellular membranes. A multitude of ARA studies revealed decreased EPA deposition in fish in response to increasing dietary ARA levels 17,20,22,73,82–84,86,92,94–98,104,105,108–114,116,121,125,135,136,139,140,151,163,172,176,209,210 . Therefore, no doubts should be present that increased dietary ARA displaces EPA retention in fish tissues.…”

Section: Interaction Between Ara and Other Nutrients And Non‐nutrient...mentioning

confidence: 99%

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Arachidonic acid matters

Meng

Wei

et al. 2022

Reviews in Aquaculture

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Throughout the evolution of fish nutrition science, the importance of dietary arachidonic acid (ARA, 20:4n‐6) has been somewhat overlooked, likely due to the polarizing research focus on docosahexaenoic (DHA, 22:6n‐3) and eicosapentaenoic (EPA, 20:5n‐3) acids. Nevertheless, especially during the past two decades, increasing attention has been paid to the requirements and functions of ARA in fish nutrition, and a number of relevant studies have now been conducted on a series of fish species, including both marine and freshwater species. Those studies revealed important and diverse functions of ARA in various physiological processes, such as growth, reproduction, stress resistance, pigmentation, immunity, lipid deposition and bone development. The results of the present review, in addition to providing a state‐of‐the‐art summary of current knowledge, also revealed the complexity of ARA functions in terms of dosages, species, development stage, sex and feeding period, as well as in terms of interaction between ARA and other nutritional or non‐nutritional factors.

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Section: Interaction Between Ara and Other Lc-pufamentioning

confidence: 99%

Section: Interaction Between Ara and Other Nutrients And Non‐nutrient...mentioning

confidence: 99%

Arachidonic acid matters

Meng

Wei

et al. 2022

Reviews in Aquaculture

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“…For example, it has been shown in vitro that beta-lactams can suppress arachidonic acid release from platelets to form thromboxanes [74]. In another study, a combination of ampicillin and chloramphenicol increased eicosanoid concentrations [75]. Therefore, both antibiotics might have an impact on eicosanoid formation.…”

Section: Discussionmentioning

confidence: 99%

The Serum and Fecal Metabolomic Profiles of Growing Kittens Treated with Amoxicillin/Clavulanic Acid or Doxycycline

Stavroulaki

Suchodolski

Pilla

et al. 2022

Animals

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The long-term impact of antibiotics on the serum and fecal metabolome of kittens has not yet been investigated. Therefore, the objective of this study was to evaluate the serum and fecal metabolome of kittens with an upper respiratory tract infection (URTI) before, during, and after antibiotic treatment and compare it with that of healthy control cats. Thirty 2-month-old cats with a URTI were randomly assigned to receive either amoxicillin/clavulanic acid for 20 days or doxycycline for 28 days, and 15 cats of similar age were enrolled as controls. Fecal samples were collected on days 0, 20/28, 60, 120, and 300, while serum was collected on days 0, 20/28, and 300. Untargeted and targeted metabolomic analyses were performed on both serum and fecal samples. Seven metabolites differed significantly in antibiotic-treated cats compared to controls on day 20/28, with two differing on day 60, and two on day 120. Alterations in the pattern of serum amino acids, antioxidants, purines, and pyrimidines, as well as fecal bile acids, sterols, and fatty acids, were observed in antibiotic-treated groups that were not observed in control cats. However, the alterations caused by either amoxicillin/clavulanic acid or doxycycline of the fecal and serum metabolome were only temporary and were resolved by 10 months after their withdrawal.

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“…[7,8] Moreover, it is worth noting that CHL has been identified as a potential carcinogen with documented immunosuppressive effects upon excessive usage. [9,10] Chloramphenicol enters the gastrointestinal tract and directly or indirectly interacts with digestive enzymes. However, the interaction between CHL and digestive enzymes remains poorly understood, including its potential harmful effects on the functional activity of pepsin.…”

Section: Introductionmentioning

confidence: 99%

“…This process can potentially impede alterations in the protein's microenvironment, conformational dynamics, and overall structure, thereby influencing their biological activity and functionality [7,8] . Moreover, it is worth noting that CHL has been identified as a potential carcinogen with documented immunosuppressive effects upon excessive usage [9,10] …”

Section: Introductionmentioning

confidence: 99%

Effect of Chloramphenicol as Antibiotic on the Structure and Function of Pepsin and Its Mechanism of Action

Wang,

Sun,

Nie

et al. 2023

Chemistry & Biodiversity

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The interaction between chloramphenicol (CHL) and pepsin (PEP), as well as the impact of CHL on PEP conformation, were investigated using spectroscopic techniques and molecular docking simulations in this study. The experimental results demonstrate that CHL exhibits a static quenching effect on PEP. The thermodynamic parameters indicate that the reaction between CHL and PEP is spontaneous, primarily driven by hydrogen bonding and van der Waals forces. Moreover, the binding distance of r<7 nm suggests the occurrence of Förster's non‐radiative energy transfer between these two molecules. In the synchronous fluorescence spectrum, the maximum fluorescence intensity of PEP produced a redshift phenomenon, indicating that CHL was bound to tryptophan residues of PEP. The addition of CHL induces changes in the secondary structure of PEP, as confirmed by the observed alterations in peak values in three‐dimensional fluorescence spectra. The UV spectra reveal a redshift of 3 nm in the maximum absorption peak, indicating a conformational change in the secondary structure of PEP upon addition of CHL. Circular dichroism analysis demonstrates significant alterations in the α‐helix, β‐sheet, β‐turn, and random coil contents of PEP before and after CHL incorporation, further confirming its ability to modulate the secondary structure of PEP.

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The effect of antibiotic exposure on eicosanoid generation from arachidonic acid and gene expression in a primitive chordate,Branchiostoma belcheri

Cited by 4 publications

References 39 publications

Arachidonic acid matters

Arachidonic acid matters

The Serum and Fecal Metabolomic Profiles of Growing Kittens Treated with Amoxicillin/Clavulanic Acid or Doxycycline

Effect of Chloramphenicol as Antibiotic on the Structure and Function of Pepsin and Its Mechanism of Action

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