2022
DOI: 10.3390/ani12030330
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The Serum and Fecal Metabolomic Profiles of Growing Kittens Treated with Amoxicillin/Clavulanic Acid or Doxycycline

Abstract: The long-term impact of antibiotics on the serum and fecal metabolome of kittens has not yet been investigated. Therefore, the objective of this study was to evaluate the serum and fecal metabolome of kittens with an upper respiratory tract infection (URTI) before, during, and after antibiotic treatment and compare it with that of healthy control cats. Thirty 2-month-old cats with a URTI were randomly assigned to receive either amoxicillin/clavulanic acid for 20 days or doxycycline for 28 days, and 15 cats of … Show more

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Cited by 7 publications
(9 citation statements)
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“…Compared to serum metabolites, fecal metabolites may be more representative of the direct microbial metabolic products produced in the gut. On the other hand, these metabolites eventually can enter the liver, muscle, adipose tissue, and brain, where they signal through targeting host molecules and affecting host signaling pathways ( Koh and Bäckhed, 2020 ; Stavroulaki et al, 2022 ). While there have been many studies describe microbial metabolites in obesity, type 2 diabetes, non-alcoholic fatty liver disease, and other metabolic diseases ( Pedersen et al, 2016 ; Wahlström et al, 2016 ; Federici, 2019 ).…”
Section: Introductionmentioning
confidence: 99%
“…Compared to serum metabolites, fecal metabolites may be more representative of the direct microbial metabolic products produced in the gut. On the other hand, these metabolites eventually can enter the liver, muscle, adipose tissue, and brain, where they signal through targeting host molecules and affecting host signaling pathways ( Koh and Bäckhed, 2020 ; Stavroulaki et al, 2022 ). While there have been many studies describe microbial metabolites in obesity, type 2 diabetes, non-alcoholic fatty liver disease, and other metabolic diseases ( Pedersen et al, 2016 ; Wahlström et al, 2016 ; Federici, 2019 ).…”
Section: Introductionmentioning
confidence: 99%
“…For example, unlike in dogs, no studies depict the normal development of BA pools in healthy cats. Presently, studies are largely limited to evaluations of healthy cats within the context of diet modifications [ 156 , 157 , 158 ] and antimicrobial administration [ 159 , 160 ], or in states of disease such as kittens with upper respiratory infections (URIs) [ 161 ], feline CKD [ 162 ], and feline chronic enteropathy [ 163 ]. Herein, the current evidence available regarding feline BAs will be reviewed.…”
Section: Feline Microbial-derived Bile Acidsmentioning
confidence: 99%
“…Microbial-derived SBAs have also been studied in states of disease in cats including kittens with URIs given antimicrobials [ 161 ], feline CKD [ 162 , 166 ], and feline CE [ 163 ]. The development and maturation of the fecal BA pools has recently been characterized in kittens with URIs starting at 2 months of age up to approximately one year [ 161 ].…”
Section: Feline Microbial-derived Bile Acidsmentioning
confidence: 99%
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