The Effect of Antimicrobial Periodontal Treatment on Circulating Tumor Necrosis Factor‐Alpha and Glycated Hemoglobin Level in Patients With Type 2 Diabetes

Iwamoto, Yoshihiro; Nishimura, Fusanori; Nakagawa, Masatsugu; Sugimoto, Hikaru; Shikata, Kenichi; Makino, Hírofumi; Fukuda, Tsuyoshi; Tsuji, Takao; Iwamoto, Masahiro; Murayama, Yoji

doi:10.1902/jop.2001.72.6.774

Cited by 244 publications

(247 citation statements)

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“…These findings were in accordance with the previous studies [10,21]. However, Talbert et al, demonstrated no changes in the TNf-α and IL-6 levels in GCf after non-surgical treatment of periodontitis in type 2diabetic subjects [11].…”

Section: Non-surgical Periodontal Therapy (Srp)-effect On Glycaemic Csupporting

confidence: 93%

“…TNf-α level in the serum and gingival crevicular fluid before and after periodontal therapy have shown varying results [10,11].…”

Section: Discussionmentioning

confidence: 99%

“…A number of interventional studies have shown that periodontal treatment may help in the improvement of metabolic control in type 2 diabetic patients [10,11,[16][17][18][19]. However, contradictory results have been demonstrated in other studies regarding the effects of periodontal therapy on glycaemic control [20][21][22].…”

Section: Non-surgical Periodontal Therapy (Srp)-effect On Glycaemic Cmentioning

confidence: 99%

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The Effect of Scaling and Root Planing on Glycaemic Control, Periodontal Status and Gingival Crevicular f luid TN f - α Levels in an Indian Population- To Reveal the Ambivalent Link

K¹,

Suchetha

Puzhankara

et al. 2014

JCDR

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Section: Non-surgical Periodontal Therapy (Srp)-effect On Glycaemic Csupporting

confidence: 93%

“…TNf-α level in the serum and gingival crevicular fluid before and after periodontal therapy have shown varying results [10,11].…”

Section: Discussionmentioning

confidence: 99%

Section: Non-surgical Periodontal Therapy (Srp)-effect On Glycaemic Cmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Scaling and Root Planing on Glycaemic Control, Periodontal Status and Gingival Crevicular f luid TN f - α Levels in an Indian Population- To Reveal the Ambivalent Link

K¹,

Suchetha

Puzhankara

et al. 2014

JCDR

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“…Elevated levels of TNF-a may be associated with increased risk for future development of atherosclerosis in periodontitis patients with type 2 diabetes mellitus. 57,58 TNF-a is closely associated with not only insulin resistance but also with vascular atherogenic changes. 59,60 SOSC genes are positively induced by cytokines.…”

Section: Periodontitis and Aortic Insulin Signaling D Ekuni Et Almentioning

confidence: 99%

Effects of periodontitis on aortic insulin resistance in an obese rat model

Ekuni

Tomofuji

Irie

et al. 2010

Laboratory Investigation

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The combination of obesity and its associated risk factors, such as insulin resistance and inflammation, results in the development of atherosclerosis. However, the effects of periodontitis on atherosclerosis in an obese body remain unclear. The aim of the study was to investigate the effects of ligature-induced periodontitis in Zucker fatty rats on initiation of atherosclerosis by evaluating aortic insulin resistance. Zucker fatty rats (n ¼ 24) were divided into two groups. In the periodontitis group, periodontitis was ligature-induced for 4 weeks, whereas the control group was left unligated. After the 4-week experimental period, descending aorta was used for measuring the levels of lipid deposits, immunohistochemical analysis, and evaluation of gene expression. Levels of serum C-reactive protein (CRP), tumor necrosis factora (TNF-a), and insulin were also measured. Rats in the periodontitis group had significantly enhanced lipid deposits in the aorta, but not in the control group. Expression of suppressor of cytokine signaling 3, vascular cell adhesion molecule 1, reactive oxygen species, nitrotyrosine, and endothelin-1 in the periodontitis group was more intense than that in the control group. Significantly decreased levels of phosphatidylinositol 3-kinase (Pi3k) catalytic b-polypeptide (Pi3kcb), Pi3kp85, and insulin receptor substrate 1 and 2 were observed in the periodontitis group. Levels of serum CRP and TNF-a were significantly increased in the periodontitis group. Under insulin-stimulated conditions, aorta in the periodontitis group altered the Akt phosphorylation. Periodontitis in obesity induced the initial stage of atherosclerosis and disturbed aortic insulin signaling.

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“…Therefore, it was hypothesized that DM-induced exaggeration of host immune responses played a crucial role in periodontal pathogenesis 12) , as glucose-mediated advanced glycation end products can increase the production of proinflammatory cytokines and mediators, which could contribute to periodontal destruction 22) . Periodontal disease may also affect blood glucose levels in diabetic patients through insulin resistance 5) . There has been a recent focus on understanding the negative influences of oral chronic inflammation on systemic health 10,12) .…”

Section: Introductionmentioning

confidence: 99%

Clinical Case Report of Long-term Follow-up in Type-2 Diabetes Patient with Severe Chronic Periodontitis and Nifedipine-induced Gingival Overgrowth

Shibukawa

Fujinami

Yamashita

2012

Bull. Tokyo Dent. Coll.

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In this case report, we describe the clinical course over a 14-year follow-up in a 47-year-old diabetes patient with severe chronic periodontitis and nifedipine-induced gingival overgrowth. The patient had a history of hypertension for over 5 years and uncontrolled type 2 diabetes. Overgrown gingiva was observed in most of the teeth and was marked in the upper and lower anterior teeth. A probing pocket depth of ≥4 mm and bleeding on probing (BOP) were observed in 94 and 90% of sites examined, respectively. At baseline, his hemoglobin A1c (HbA1c) was 8.5%. The patient received periodontal and diabetic treatment simultaneously. Medication was changed from nifedipine chloride to an angiotensin-converting enzyme inhibitor. After initial therapy and subsequent periodontal surgery, gingival overgrowth disappeared and probing depth and BOP showed a significant improvement. No recurrence was observed during supportive periodontal therapy (SPT). The HbA1c level improved from 8.5 to 6.3% after periodontal treatment, subsequently remaining at a good level during SPT over 10 years. This study demonstrated that periodontal treatment, withdrawal of medication and control of diabetes can result in remarkable improvements in type 2 diabetes patients with chronic periodontitis and nifedipine-induced gingival overgrowth. These results suggest that comprehensive periodontal treatment in combination with treatment for diabetes mellitus can exert a positive influence on blood glucose levels and periodontal condition in diabetic patients.Key words: Chronic periodontitis -Nifedipine -Gingival overgrowthType 2 diabetes -Case report Case Report 91Bull Tokyo Dent Coll (2012) 53(2): 91-99

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The Effect of Antimicrobial Periodontal Treatment on Circulating Tumor Necrosis Factor‐Alpha and Glycated Hemoglobin Level in Patients With Type 2 Diabetes

Abstract: The results indicate that anti-infectious treatment is effective in improving metabolic control in diabetics, possibly through reduced serum TNF-alpha and improved insulin resistance.

Cited by 244 publications

References 21 publications

The Effect of Scaling and Root Planing on Glycaemic Control, Periodontal Status and Gingival Crevicular f luid TN f - α Levels in an Indian Population- To Reveal the Ambivalent Link

The Effect of Scaling and Root Planing on Glycaemic Control, Periodontal Status and Gingival Crevicular f luid TN f - α Levels in an Indian Population- To Reveal the Ambivalent Link

Effects of periodontitis on aortic insulin resistance in an obese rat model

Clinical Case Report of Long-term Follow-up in Type-2 Diabetes Patient with Severe Chronic Periodontitis and Nifedipine-induced Gingival Overgrowth

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