2021
DOI: 10.1177/03635465211011748
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The Effect of Antiosteoporosis Therapy With Risedronate on Rotator Cuff Healing in an Osteoporotic Rat Model

Abstract: Background: Osteoporosis increases the revision rate of rotator cuff repair (RCR). Weak fixation might not be the only cause of high RCR failure rates. The biological mechanism associated with tendon-to-bone healing after RCR in osteoporosis should be investigated. Hypothesis: (1) Osteoporosis would impair rotator cuff healing through the high osteoclastic activity at the repaired interface. (2) Risedronate would promote rotator cuff healing by reducing osteoclastic activity at the repaired interface. Study De… Show more

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Cited by 28 publications
(52 citation statements)
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“…After 12 weeks, the osteoporotic rat model was confirmed using micro-CT, according to a previous report. 52…”
Section: Methodsmentioning
confidence: 99%
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“…After 12 weeks, the osteoporotic rat model was confirmed using micro-CT, according to a previous report. 52…”
Section: Methodsmentioning
confidence: 99%
“…4-0 Prolene suture (Ethicon). 33,52 After the greater tuberosity was prepared by debriding all the fibrocartilage and soft tissue until bleeding was noted, 2 bone tunnels were created using a 22-gauge needle (Olympus) at the articular margin of the footprint in a crossed fashion. Then the tendon was reattached to its footprint using the free suture ends shuttled through the tunnels, followed by a routine closure in layers.…”
Section: Methodsmentioning
confidence: 99%
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