The Effect of Antioxidant Caffeic Acid Phenethyl Ester (Cape) on Some Enzyme Activities in Cisplatin-Induced Neurotoxicity in Rats

Ozyurt, Birsen; Güleç, Mukaddes; Özyurt, Hüseyın; Ekici, Filiz; Atis, Omer; Akbaş, Ali

doi:10.29333/ejgm/82401

Cited by 21 publications

(14 citation statements)

References 35 publications

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“…NADPH is required for many essential cellular processes such as the antioxidant system, nitric oxide synthase, cytochrome p450 enzymes and NADPH oxidase [36]. The decrease in the activity of G6PD in piroxicam alone treated group is in accordance with the report of [37]. However, concomitant administration of TRECDs revealed a dose-dependent increase in the activity of G6PD.…”

Section: Discussionsupporting

confidence: 74%

Tannin-Rich Extract of <i>Chasmanthera dependens</i> Stem Potential in Piroxicam-Induced Nephrotoxicity in Adult Male Wistar Rats

Abiola¹,

Susan²,

Olusegun³

2020

AJMB

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Piroxicam is commonly used as anti-inflammatory and pain relieving drug; however, its side effects include fluid retention, renal damage and heart failure. This study aimed at evaluating the nephroprotective role of different doses of the tannin-rich extract of Chasmanthera dependens stem (TRECDS) How to cite this paper: Abiola, T.S., Susan, A.O. and Olusegun, B.O. (2020) Tannin-Rich Extract of Chasmanthera dependens Stem Potential in Piroxicam-Induced Nephrotoxicity in Adult Male Wistar Rats.

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Section: Discussionsupporting

confidence: 74%

Tannin-Rich Extract of <i>Chasmanthera dependens</i> Stem Potential in Piroxicam-Induced Nephrotoxicity in Adult Male Wistar Rats

Abiola¹,

Susan²,

Olusegun³

2020

AJMB

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“…Normally the phenolic compounds act by scavenging free radical and quenching the lipid peroxidation [28]. As presented here caffeic acid has the ability to scavenge the free radicals [29] and attenuate the lipid peroxidation as indicated by increased levels of enzymic antioxidants in the liver [30].…”

Section: Resultsmentioning

confidence: 72%

Antioxidant Effect of Caffeic Acid on Oxytetracycline Induced Lipid Peroxidation in Albino Rats

Rajendran

Subash

2010

Ind J Clin Biochem

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Caffeic acid is a well-known phenolic compound widely present in plant kingdom. The aim of this study was to investigate the possible protective effect of caffeic acid (CA) against oxytetracycline (OXT) induced hepatotoxicity in male Albino Wistar rats. A total of 30 rats weighing 150-170 g were randomly divided into five groups of six rats in each group. Oral administration of OXT (200 mg/kg body weight/day) for 15 days produced hepatic damage as manifested by a significant increase in serum hepatic markers namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and increased plasma and hepatic lipid peroxidation indices (TBARS and hydroperoxide). The present finding shows that the levels of enzymatic antioxidants namely superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were significantly decreased in OXT intoxicated rats. Upon oral administration of caffeic acid (40 mg/kg body weight/day) there were decreased hepatic marker activities, bilirubin and lipid peroxidation and increased enzymatic antioxidants in OXT ? Caffeic acid group compared to Normal ? OXT group(P \ 0.05). Our study suggests that caffeic acid has antioxidant property and hepatoprotective ability against OXT induced toxicity.

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“…Defects in mitochondria in relation to oxidative damage seems to play pivotal role in cell death induced by CP . A direct link between mitochondrial dysfunction and toxic exposure of anticancer drugs has been established .…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9][10] Defects in mitochondria in relation to oxidative damage seems to play pivotal role in cell death induced by CP. 11,12 A direct link between mitochondrial dysfunction and toxic exposure of anticancer drugs has been established. [13][14][15] CP-induced nephrotoxicity studies suggest that augmented reactive oxygen species (ROS) generation, with consequent impairment of mitochondrial function and structure, may be a detrimental factor.…”

Section: Introductionmentioning

confidence: 99%

Mitochondria‐mediated mitigatory role of curcumin in cisplatin‐induced nephrotoxicity

Waseem

Kaushik

Parvez

2013

Cell Biochemistry & Function

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Cisplatin (CP) is one of the most potent chemotherapeutic anti-tumour drugs, and it has been implicated in renal toxicity. Oxidative stress has been proven to be involved in CP-induced toxicity including nephrotoxicity. However, there is paucity of literature involving role of mitochondria in mediating CP-induced renal toxicity, and its underlying mechanism remains unclear. Therefore, the present study was undertaken to examine the antioxidant potential of curcumin (CMN; a natural polyphenolic compound) against the mitochondrial toxicity of CP in kidneys of male rats. Acute toxicity was induced by a single intra-peritoneal injection of CP (6 mg kg(-1) ). We studied the ameliorative effect of CMN pre-treatment (200 mg kg(-1) ) on the toxicity of CP in rat kidney mitochondria. CP caused a significant elevation in the mitochondrial lipid peroxidation (LPO) levels and protein carbonyl (PC) content. Pre-treatment of rat with CMN significantly replenished the mitochondrial LPO levels and PC content. It also restored the CP-induced modulatory effects on altered enzymatic and non-enzymatic antioxidants in kidney mitochondria. We hypothesize that the reno-protective effects of CMN may be related to its predisposition to scavenge free radicals, and upregulate antioxidant machinery in kidney mitochondria.

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The Effect of Antioxidant Caffeic Acid Phenethyl Ester (Cape) on Some Enzyme Activities in Cisplatin-Induced Neurotoxicity in Rats

Cited by 21 publications

References 35 publications

Tannin-Rich Extract of <i>Chasmanthera dependens</i> Stem Potential in Piroxicam-Induced Nephrotoxicity in Adult Male Wistar Rats

Tannin-Rich Extract of <i>Chasmanthera dependens</i> Stem Potential in Piroxicam-Induced Nephrotoxicity in Adult Male Wistar Rats

Antioxidant Effect of Caffeic Acid on Oxytetracycline Induced Lipid Peroxidation in Albino Rats

Mitochondria‐mediated mitigatory role of curcumin in cisplatin‐induced nephrotoxicity

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The Effect of Antioxidant Caffeic Acid Phenethyl Ester (Cape) on Some Enzyme Activities in Cisplatin-Induced Neurotoxicity in Rats

Cited by 21 publications

References 35 publications

Tannin-Rich Extract of &lt;i&gt;Chasmanthera dependens&lt;/i&gt; Stem Potential in Piroxicam-Induced Nephrotoxicity in Adult Male Wistar Rats

Tannin-Rich Extract of &lt;i&gt;Chasmanthera dependens&lt;/i&gt; Stem Potential in Piroxicam-Induced Nephrotoxicity in Adult Male Wistar Rats

Antioxidant Effect of Caffeic Acid on Oxytetracycline Induced Lipid Peroxidation in Albino Rats

Mitochondria‐mediated mitigatory role of curcumin in cisplatin‐induced nephrotoxicity

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Tannin-Rich Extract of <i>Chasmanthera dependens</i> Stem Potential in Piroxicam-Induced Nephrotoxicity in Adult Male Wistar Rats

Tannin-Rich Extract of <i>Chasmanthera dependens</i> Stem Potential in Piroxicam-Induced Nephrotoxicity in Adult Male Wistar Rats