The Effect of Antiseptics on Adipose-Derived Stem Cells

Kim, Bong-Sung; Ott, Veronica; Boecker, Arne Hendrick; Stromps, Jan-Philipp; Paul, N; Alharbi, Ziyad; Cakmak, Ercan; Bucala, Richard; Pallua, Norbert

doi:10.1097/prs.0000000000003125

Cited by 22 publications

(15 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Traditional disinfectants are harsh chemical agents that can present undesirable mammalian and ecological toxicities ( Christen et al, 2017 ). Traditional antiseptic agents have also demonstrated mammalian toxicities ( Kim et al, 2017 ). Antibiotics, which are frequently naturally derived have been attractive solutions in these settings because of their lower toxicities.…”

Section: Introductionmentioning

confidence: 99%

Caprylic and Polygalacturonic Acid Combinations for Eradication of Microbial Organisms Embedded in Biofilm

et al. 2017

View full text Add to dashboard Cite

There is a need for non-antibiotic, antimicrobial compositions with low toxicity capable of broad-spectrum eradication of pathogenic biofilms in food preparation and healthcare settings. In this study we demonstrated complete biofilm eradication within 60 min with synergistic combinations of caprylic and polygalacturonic (PG) acids in an in vitro biofilm eradication model against representative hospital and foodborne infectious pathogen biofilms (methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa, Candida albicans, Escherichia coli, and Salmonella enteritidis). Antimicrobial synergy against biofilms was demonstrated by quantifying viable organisms remaining in biofilms exposed to caprylic acid alone, PG acid alone, or combinations of the two. The combinations also synergistically inhibited growth of planktonic organisms. Toxicity of the combination was assessed in vitro on L929 fibroblasts incubated with extracts of caprylic and PG acid combinations using the Alamar Blue metabolic activity assay and the Trypan Blue exclusion cell viability assay. The extracts did not produce cytotoxic responses relative to untreated control fibroblasts.

show abstract

Section: Introductionmentioning

confidence: 99%

Caprylic and Polygalacturonic Acid Combinations for Eradication of Microbial Organisms Embedded in Biofilm

et al. 2017

View full text Add to dashboard Cite

show abstract

“… 22 – 24 Furthermore, intraoperatively available sterile povidone-iodine is often at a concentration of 3%, which showed no significant reduction in cell viability even in the literature reporting concern for adipose stem cells. 21 …”

Section: Discussionmentioning

confidence: 99%

Optimal Irrigant in High Pressure Paint Injection Injuries of the Hand

Bascone

Sheber

Davé

et al. 2022

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

Background: High pressure injection injury to the hand with paint leads to amputation rates near 48%. Historically, authors utilized saline irrigation alone, but have high reoperation rates. We conducted a cadaveric study to determine the ideal detergent for effective paint removal from the soft tissue. Methods: Two cadaveric hands were amputated from the same cadaver. The left and right hand digits were injected with flat white latex-based paint and flat white oil-based paint, respectively. Each digit received a longitudinal incision and was scrubbed for 120 seconds with 50 mL of a randomly assigned detergent and no detergent (saline) as the control. After achieving a lather, each finger was cleansed with 50 mL saline before being evaluated by two blinded hand surgery faculty. Reviewers assessed the washouts as adequate or inadequate, in order to generate a Kappa statistic and measure inter-rater reliability prior to ranking each digit (1 through 5) (ie, 1 = most paint-free soft tissue). Results: The two hand faculty had an inter-rater reliability of 0.70. Both reviewers ranked povidone-iodine 10% or Johnson & Johnson shampoo as the best irrigant for latex-based paint. In oil-based paint, povidone-iodine 10%, Johnson & Johnson, & Techni-care were ranked as top three. All reviewers reported detergents were better than saline alone. Conclusions: The addition of detergent created an irrigant that removed both latex- and oil-based paint better than normal saline alone. Based on these results, surgeons treating high-pressure injection injury should consider using Povidone-Iodine 10% or Johnson & Johnson baby shampoo for latex- or oil-based paint.

show abstract

“…In the case of the rest of the products such dilution of the substance led to no significant decline in viability of the cells. What is more, Octenisept ® decreased the ability of the adipose-derived stem cells to proliferate by over 70% and ability to differentiate by nearly 80% [18]. In the other research the influence of various antiseptic preparations widely used and recommended in treating burn wounds was examined on human dermal fibroblasts dissected from the skin and murine fibroblasts (3T3 cells).…”

Section: Omówieniementioning

confidence: 99%

Bullous skin lesion reaction as an example of an adverse effect of a preparation containing 0.1% octenidine dihydrochloride and 2% phenoxyethanol (Octenisept®)

Hołdrowicz¹,

Pałczyński²,

Kupryś‐Lipińska³

et al. 2018

View full text Add to dashboard Cite

Introduction. Octenisept ® is an antiseptic solution which is intended to be applied on the skin, mucous membranes and wounds. Objective. To present a case study of a bullous skin lesions, which occurred in a 4-year-old girl after Octenisept ® application, and to highlight various possible side effects of this preparation. Case report. In a 4-year-old girl Octenisept ® was applied preventively three times at intervals of 12 hours on an epidermal abrasion. Erythema and hydropic papules emerged 6-8 hours after application and were followed by vesicles and bullae 8 hours later. In spite of the topical treatment with glucocorticoids and an antibiotic, the lesions persisted for several weeks. Conclusions. Taking into consideration the wide usage of Octenisept ® in many fields of medicine, there is a need to conduct further research on the allergic potential and toxicity of this product. streszczenie Wprowadzenie. Octenisept ® jest środkiem antyseptycznym przeznaczonym do stosowania na powierzchnię skóry, błon śluzowych i ran. Cel pracy. Przedstawienie przypadku reakcji pęcherzowej skóry u 4-letniej dziewczynki, która wystąpiła po aplikacji Octeniseptu ® na otarty naskórek, oraz zwrócenie uwagi na możliwe działania niepożądane tego preparatu. Opis przypadku. U 4-letniej dziewczynki zastosowano profilaktycznie Octenisept ® , spryskując otarcie naskórka 3-krotnie co 12 godzin. Zmiany skórne w postaci rumienia i grudek obrzękowych pojawiły się po 6-8 Case report/Opis przypadku bullous skin lesion reaction as an example of an adverse effect of a preparation containing 0.1% octenidine dihydrochloride and 2% phenoxyethanol (Octenisept ®) reakcja pęcherzowa skóry jako przykład niepożądanego działania preparatu zawierającego 0,1% dichlorowodorku oktenidyny i 2% fenoksyetanolu (Octenisept ®

show abstract

The Effect of Antiseptics on Adipose-Derived Stem Cells

Cited by 22 publications

References 44 publications

Caprylic and Polygalacturonic Acid Combinations for Eradication of Microbial Organisms Embedded in Biofilm

Caprylic and Polygalacturonic Acid Combinations for Eradication of Microbial Organisms Embedded in Biofilm

Optimal Irrigant in High Pressure Paint Injection Injuries of the Hand

Bullous skin lesion reaction as an example of an adverse effect of a preparation containing 0.1% octenidine dihydrochloride and 2% phenoxyethanol (Octenisept®)

Contact Info

Product

Resources

About