The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection

Zuckerman, Eli; Zuckerman, Tsila; Sahar, Dvora; Streichman, Sara; Attias, Dina; Sabo, Edmond; Yeshurun, Daniel; Rowe, Jacob M.

doi:10.1182/blood.v97.6.1555

Cited by 117 publications

(62 citation statements)

References 31 publications

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“…Furthermore, the reappearance of translocated B-lymphocyte clones is observed in patients whose HCV infection initially responded to interferon treatment and then relapsed. This confirms the hypothesis that the expanded B-lymphocyte clone needs persistent treatment of the infective stimulus (25)(26)(27).…”

Section: Discussionsupporting

confidence: 77%

Lacrimal Gland Marginal Zone Lymphoma: Regression after Treatment of Chronic Hepatitis C Virus Infection: Case Report and Review of the Literature

Çoşkun

Yukselen

et al. 2013

Intern. Med.

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A 43-year-old woman was first admitted to the ophthalmology clinic with the complaint of a mass compressing the right eye. Based on clinical and laboratory examinations she was diagnosed as having marginal zone lymphoma (MZL) of the right lacrimal gland in addition to hepatitis C virus (HCV) infection. After the treatment for HCV infection with pegylated interferon plus ribavirin, a radiographic response of the MZL was obtained; she remains in remission through thirty months of clinical follow-up. In this case, the treatment of HCV infection led to regression of MZL suggesting the necessity of testing for HCV infection and treatment of the HCV infection should be highly considered in all HCV-positive patients with MZL's.

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Section: Discussionsupporting

confidence: 77%

Lacrimal Gland Marginal Zone Lymphoma: Regression after Treatment of Chronic Hepatitis C Virus Infection: Case Report and Review of the Literature

Çoşkun

Yukselen

et al. 2013

Intern. Med.

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“…Also, recently, it has been suggested that HCV may induce t(14;18) translocation in chronic infected patients particularly with mixed cryoglobulinemia and less frequently in patients without MC 42 leading to an over expression of the anti-apoptotic bcl-2 42,43 and of monoclonal IgH rearrangement. 43,44 These data suggest that HCV may play a role in the multistep mechanism of lymphomagenesis by inducing clonal proliferation of B cells and inhibition of apoptosis. The treatment with interferon or by combination therapy with interferon and ribavirin was effective in disappearance of IgH rearrangement and t(14;18) translocation.…”

Section: Discussionmentioning

confidence: 94%

Primary Lymphoma of the Liver: Clinical–Pathological Features and Relationship With Hcv Infection in French Patients

et al. 2003

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Primary lymphoma of the liver (PLL) is rare. In some cases, the hepatic lymphoma has been diagnosed in patients who were infected by the hepatitis C virus (HCV). It has been suggested that HCV plays a role in the pathogenesis of lymphoma. The aim of our multicentric retrospective study was to assess the characteristics of PLL and to determine the prevalence of HCV infection in PLL. Thirty-one immunocompetent patients (anti-human immunodeficiency virus, anti-human T-cell leukemia/lymphoma virus negative, no history of allograft) with PLL fulfilled the entire selection criteria. The liver biopsy specimens were reassessed by the same pathologist. The non-Hodgkin's lymphomas were classified according to the World Health Organization classification. Blood samples were tested in 28 patients for antibodies to HCV, and HCV RNA was detected by reverse transcription polymerase chain reaction. In the majority of cases, the clinical, biologic, and radiologic data were nonspecific. Twentyseven of 31 patients presented a B-cell lymphoma corresponding to the centroblastic morphologic variant of a diffuse, large B-cell lymphoma (22 cases), a Burkitt's lymphoma (1 case), an extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type (3 cases), and unclassified, small B-cell lymphoma (1 case). The 4 other cases were T-cell lymphomas. The prevalence of HCV infection was 21% (6 of 28 cases). All of these patients were positive for HCV RNA by polymerase chain reaction in blood. Most of the HCVinfected patients presented a high-grade, B-cell type lymphoma. In conclusion, our study confirms the rarity of PLL and demonstrates an increased prevalence of HCV infection. H epatitis C virus (HCV) is a hepatotropic virus;however, the HCV genome and its replicative intermediate have been detected in peripheral blood mononuclear cells in patients with chronic HCV infection. 1,2 There is a strong association between HCV and type II mixed cryoglobulinemia. [3][4][5] Antibodies to HCV and HCV RNA have been found in up to 98% of patients with mixed cryoglobulinemia, 3 and approximately 36% of patients with chronic HCV infection have mixed cryoglobulinemia. 5 Mixed cryoglobulinemia is considered by some investigators to be a variant of lowgrade, B-cell non-Hodgkin's lymphoma. 6,7 This has prompted several groups to investigate the association between HCV infection and overt B-cell malignancies. Evidence suggesting a direct relationship between HCV infection and development of these tumors have been reported in several Italian studies and in one American study, which demonstrates a high prevalence of chronic HCV infection, 9% to 42%, in patients with B-cell lymphoma. [8][9][10][11] However, data from other countries have not confirmed these findings. [12][13][14][15] Primary lymphoma of the liver (PLL) is rare, with less than 150 cases reported. 16,17 In some cases, the hepatic lymphoma was diagnosed in From the

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“…Support for the potential role of HCV in lymphomagenesis derives from observations that effective HCV treatment has been paralleled by reduction of detectable lymphocytes with the t(14;18) translocation 40 and regression of rare cases of splenic marginal zone lymphoma have been described after successful treatment of HCV infection. 41 Our data, however, do not support a role of HCV in the development of HIV-associated systemic AIDS-related NHL.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C infection is not associated with systemic HIV‐associated non‐hodgkin's lymphoma: A cohort study

Waters¹,

Stebbing²,

Mandalia³

et al. 2005

Intl Journal of Cancer

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Immunosuppression induced by the human immunodeficiency virus (HIV) increases the risk of developing non-Hodgkin's lymphoma (NHL). As the hepatitis C virus (HCV) has been implicated in the development of B cell lymphomas, we compared the incidence of systemic NHL during HIV infection compared to HIV and HCV co-infection. Of 5,832 individuals studied during the era of highly active anti-retroviral therapy (HAART), 102 patients were diagnosed with systemic NHL. The incidence of systemic NHL was 6.9 of 10 4 patient years during HIV infection compared to 7.1 of 10 4 patient years during HIV alone (p ¼ 0.9). In this immunocompromised patient population, there was no association between HCV infection and an increased risk of lymphoma. ' 2005 Wiley-Liss, Inc.Key words: hepatitis C; HIV; non-Hodgkin's lymphomaThe use of HAART has resulted in marked declines in HIVrelated morbidity and mortality, by mainly reducing the incidence of opportunistic infections 1 High grade B-cell non-Hodgkin's lymphoma (NHL) is an AIDS defining illness, having first been described in association with HIV in the early 1980s. 2 NHL occurs at a greatly increased frequency in HIV-infected populations and despite a reduction in its incidence during the HAART era, it remains the second commonest AIDS defining malignancy after Kaposi's sarcoma. [3][4][5][6][7] Many of the 200 million individuals infected with HCV and the 50 million individuals infected with HIV are co-infected with both viruses. [8][9][10] As well as shared routes of transmission, there are many interactions between these small RNA viruses in which infection is often characterised by parenteral transmission followed by a seroconversion illness and then a long latent period lasting many years. 11 Once established, HIV-1 infection seems to increase the persistence of the hepatitis C virus, the level of HCV RNA and progression of HCV-related disease. [12][13][14][15][16] There are conflicting reports concerning whether HCV infection alters the course of HIV. 17 Some studies before the advent of highly active anti-retroviral therapy (HAART) suggested that survival and progression to AIDS were the same in patients with HCV/HIV co-infection as in those with HIV alone 18,19 whereas others suggested an adverse effect. 13,20 In the pre-HAART era, HCV infection was deemed an irrelevance as it was HIV that affected morbidity and mortality. With the increased life expectancy of individuals with HIV, however, HCV has emerged as a problem that adversely affects survival of individuals with HIV. 8,16,21 HCV is a well-established risk factor in the etiology of hepatocellular carcinomas and of mixed cryoglobulinemia Type II, a condition that can evolve to malignant lymphoma in 8-10% of affected cases. 22 In the non-HIV setting, data from case-case comparisons and case-control studies indicate several-fold higher prevalence of HCV infection (as indicated by the presence of antibodies or HCV RNA) among B cell lymphoma patients compared to control populations. 23 Attempts have been made to evaluate an...

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The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection

Cited by 117 publications

References 31 publications

Lacrimal Gland Marginal Zone Lymphoma: Regression after Treatment of Chronic Hepatitis C Virus Infection: Case Report and Review of the Literature

Lacrimal Gland Marginal Zone Lymphoma: Regression after Treatment of Chronic Hepatitis C Virus Infection: Case Report and Review of the Literature

Primary Lymphoma of the Liver: Clinical–Pathological Features and Relationship With Hcv Infection in French Patients

Hepatitis C infection is not associated with systemic HIV‐associated non‐hodgkin's lymphoma: A cohort study

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