The effect of aqueous progesterone on operative adhesion formation

Maurer, James H.; Bonaventura, Leo M.

doi:10.1016/s0015-0282(16)46937-2

Cited by 31 publications

(10 citation statements)

References 11 publications

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“…One major category of drugs attempted to mitigate the effects of inflammation in promoting adhesion formation. A variety of steroidal [8][9][10][11] and non-steroidal anti-inflammatory compounds [12][13][14][15][16] have been tested, as well as agents that interfere with specific cytokines [17] or vascular permeability [18], chemotherapeutic agents [19] and immunosuppressive drugs [20]. In a related vein, many agents that scavenge the free radicals generated by inflammation have been tested [21,22].…”

Section: Pharmacological Approaches To Preventing Peritoneal Adhesionsmentioning

confidence: 99%

Polymers in the prevention of peritoneal adhesions

Yeo

Kohane

2008

European Journal of Pharmaceutics and Biopharmaceutics

108

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Peritoneal adhesions are serious complications of surgery, and can result in pain, infertility, and potentially lethal bowel obstruction. Pharmacotherapy and barrier devices have reduced adhesion formation to varying degrees in preclinical studies or clinical trials; however, complete prevention of adhesions remains to be accomplished. We and others have hypothesized that the limitations of the two approaches could be overcome by combining their strengths in the context of controlled drug delivery. Here we review the role of polymeric systems in the prevention of peritoneal adhesions, with an emphasis on our recent work in developing and applying polymeric drug delivery systems such as nano-or microparticles, hydrogels, and hybrid systems for peritoneal use.

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Section: Pharmacological Approaches To Preventing Peritoneal Adhesionsmentioning

confidence: 99%

Polymers in the prevention of peritoneal adhesions

Yeo

Kohane

2008

European Journal of Pharmaceutics and Biopharmaceutics

108

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“…Previous studies suggested a protective role of progestins against adhesion development, possibly due to their immunosuppressive potential combined with the creation of a hypoestrogenic environment [6,7]. Our results suggest that adhesion tissue fibroblasts would not be susceptible to progesterone, neither at low or high estradiol concentrations.…”

Section: Discussionmentioning

confidence: 44%

The effect of estradiol on the expression of estrogen, progesterone, androgen, and prolactin receptors in human peritoneal fibroblasts

Detti

Saed

Jiang

et al. 2008

J Assist Reprod Genet

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“…Progestogens have been investigated for the prevention of adhesion formation by several authors [8,15,16]. The preoperative administration of MPA to rabbits has reduced the autoantibody titers to peritoneum and myometrium [16] which supports the anti-inflammatory and immunosuppressive actions of progestogens.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ringer’s Lactate, Medroxyprogesterone Acetate, Gonadotropin-Releasing Hormone Analogue and Its Diluent on the Prevention of Postsurgical Adhesion Formation in Rat Models

Üstün

Yanık

Koçak

et al. 1998

Gynecol Obstet Invest

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Fifty adult female rats were randomly divided into five groups. Before the standard surgical procedure which consisted of creating a lesion with electrocautery over the uterus, leuprolide acetate (LA) together with its diluent, the diluent alone and medroxyprogesterone acetate (MPA) were injected to the third, fourth, and fifth groups, respectively. Ringer’s lactate (RL) solution was applied intraperitoneally to the second group at the end of the surgery. Group I received no medication. Relaparotomy was performed 3 weeks later to evaluate the adhesions. The mean adhesion scores were (mean ± SD) 2.6 ± 0.7, 1.4 ± 0.8, 0.9 ± 0.6, 2.3 ± 0.8, and 0.8 ± 0.6 in groups I, II, III, IV, and V, respectively. The postsurgical adhesions were significantly less in the groups treated with RL, LA, and MPA.

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The effect of aqueous progesterone on operative adhesion formation

Cited by 31 publications

References 11 publications

Polymers in the prevention of peritoneal adhesions

Polymers in the prevention of peritoneal adhesions

The effect of estradiol on the expression of estrogen, progesterone, androgen, and prolactin receptors in human peritoneal fibroblasts

Effects of Ringer’s Lactate, Medroxyprogesterone Acetate, Gonadotropin-Releasing Hormone Analogue and Its Diluent on the Prevention of Postsurgical Adhesion Formation in Rat Models

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