The Effect of Arginine-vasopressin and its Analogues upon the Endocochlear Potential in the Guinea Pig

Mori, Nozomu; Shugyo, A.; Asai, Hideyo

doi:10.3109/00016488909127482

Cited by 19 publications

(2 citation statements)

References 18 publications

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“…In addition, it was reported previously that V 2 -R mediated the action of VP on the endocochlear potential [20]. Thus it was hypothesized in the present study that the administration of OPC-31260 before VP injection may reduce the enlargement of the intrastrial space caused by VP via the blockade of water transport from the perilymph to the the basolateral (perylymph) side of the basal cells, in which AQP2 is expressed.…”

Section: Discussionmentioning

confidence: 93%

Time course changes of vasopressin-induced enlargement of the rat intrastrial space and the effects of a vasopressin type 2 antagonist

Nishimura

Kakigi

Takeda

et al. 2009

Acta Oto-Laryngologica

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Section: Discussionmentioning

confidence: 93%

Time course changes of vasopressin-induced enlargement of the rat intrastrial space and the effects of a vasopressin type 2 antagonist

Nishimura

Kakigi

Takeda

et al. 2009

Acta Oto-Laryngologica

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“…In the guinea pig, the systemic administration of AVP decreased the endocochlear potential, an effect that was reversed by V2 receptor but not by V1 receptor antagonists [42], and elicited the development of an endolymphatic hydrops [28]. In the same species, the injection of cholera toxin, a compound that increases the intracellular concentration of cAMP, AVP V2 receptors second messenger also induced an endolymphatic hydrops [37].…”

Section: Atp and Acoustic Traumamentioning

confidence: 95%

What’s new in ion transports in the cochlea?

Couloigner

Sterkers²,

Ferrary³

2006

Pflugers Arch - Eur J Physiol

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Recent advances in the field of the physiology of inner ear fluids permitted the characterization of the molecular mechanisms involved in critical processes such as the absorption of K(+) through cochlear sensory hair cells (mechanoelectrical transduction) or the secretion of K(+) by marginal cells of the stria vascularis. In addition, new pathways for ion circulations were evidenced. Mutations of transporters involved in some of these pathways, especially in K(+) recycling through gap junction systems, and in local pH regulation, are among the most frequent etiologies of genetic deafness in humans.

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Antidiuretic hormone restores the endolymphatic longitudinal K+ gradient in the Brattleboro rat cochlea

et al. 1994

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In the cochlea, endolymph is hyperosmotic to plasma and perilymph. To test the hypothesis that antidiuretic hormone is involved in the modulation of endolymph secretion, the electrochemical composition of cochlear fluids, endolymph and perilymph, was studied in three groups of anaesthetized rats: control Long Evans rats, homozygous Brattleboro rats that are genetically deprived of antidiuretic hormone, and Brattleboro rats that were treated with antidiuretic hormone (dDAVP, 0.5 microgram/100 g body weight/24 h during 8 days). Endolymph was sampled from the scala media at each turn of the cochlea and perilymph from the scala vestibuli. In Long Evans rats, the endocochlear potential, the endolymphatic K+ and Cl- concentrations decreased from base to apex of the cochlea as previously reported in guinea pigs and Sprague Dawley rats. In Brattleboro rats, the endocochlear potential and the Cl- concentration gradients were still present, whereas the K+ concentration gradient were still present, whereas the K+ concentration gradient was absent. This K+ gradient was restored by the administration of dDAVP, which increased the K+ concentration at the base of the cochlea. This work indicates that the K+ secretion in endolymph, and thus the osmolality, may be locally modulated by the antidiuretic hormone, probably via V2 receptors.

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The Effect of Arginine-vasopressin and its Analogues upon the Endocochlear Potential in the Guinea Pig

Cited by 19 publications

References 18 publications

Time course changes of vasopressin-induced enlargement of the rat intrastrial space and the effects of a vasopressin type 2 antagonist

Time course changes of vasopressin-induced enlargement of the rat intrastrial space and the effects of a vasopressin type 2 antagonist

What’s new in ion transports in the cochlea?

Antidiuretic hormone restores the endolymphatic longitudinal K+ gradient in the Brattleboro rat cochlea

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