The effect of ascorbic acid on infection of chick-embryo ciliated tracheal organ cultures by coronavirus

Atherton, J.; Kratzing, C. C.; Fisher, Anne L.

doi:10.1007/bf01317848

Cited by 84 publications

(66 citation statements)

References 18 publications

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“…The first finding was the positive effect of AA on the trachéal lesions at 10 days after challenge. This is in agreement with the observations of Atherton et al (1978) that AA increases the resistance of the trachea to IB infections in an organ culture system. The small number of birds in the same groups with air sacculitis at 14 days may be caused by the relatively mild trachea lesions by which the risk of secondary E. coli infections was lowered (although bacterial culturing not was included in the experiment, some affected air sacs were cultured to demonstrate the presence of E. coli).…”

supporting

confidence: 93%

“…Moreover, viral infections are associated with a rapid decrease in circulating AA concentrations (Beisel, 1982) suggesting that whilst the AA concentration may be optimal for healthy birds, it is suboptimal during periods of infection. Atherton et al (1978) found that chicken-embryo tracheal organ cultures with supplemented AA were up to 15 times more resistant to infections with infectious bronchitis virus (IBV) than the controls. Increased amounts of AA in the feed of Leghorn-type chickens reduced the incidence of pericarditis or death following air sac challenge with Escherichia coli.…”

Section: Introductionmentioning

confidence: 99%

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Ascorbic acid and infectious bronchitis infections in broilers

Davelaar

Bos²

1992

Avian Pathology

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The effect of supplementing the feed of broiler chicks with different levels of ascorbic acid on the resistance against infectious bronchitis virus was investigated. Resistance was measured by the severity of tracheal lesions and the development of airsacculitis after challenge. The effect of ascorbic acid was dose dependent. Addition of 300 to 330 ppm ascorbic acid to the feed gave the best results. High concentrations (>600 ppm) had a less beneficial effect.

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supporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Ascorbic acid and infectious bronchitis infections in broilers

Davelaar

Bos²

1992

Avian Pathology

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“…En estudios con animales se ha demostrado que la vitamina C aumenta la resistencia a la infección causada por el coronavirus y también modifica la susceptibilidad a la infección 26 . Nathens et al 27 administraron 1 g de ácido ascórbico cada 8 h combinado con vitamina E oral durante 28 días en 594 pacientes quirúrgicamente críticos y encontraron una incidencia significativamente menor de lesión pulmonar aguda y fallo multiorgánico. En un estudio clínico descrito por Sawyer et al 28 se emplearon grandes dosis i.v.…”

Section: Neumonía Y Sdraunclassified

Dos terapias conocidas podrían ser efectivas como adyuvantes en el paciente crítico infectado por COVID-19

Hernández

Papadakos

Torres

et al. 2020

Revista Española de Anestesiología y Reanimación

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publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.Cómo citar este artículo: Hernández A, et al. Dos terapias conocidas podrían ser efectivas como adyuvantes en el paciente crítico infectado por COVID PALABRAS CLAVE COVID-19; SARS-CoV-2; Vitamina C; OzonoResumen La neumonía causada por coronavirus, que se originó en Wuhan, China, a finales de 2019, se ha extendido por todo el mundo convirtiéndose en una pandemia. Desafortunadamente, a día de hoy no existe ninguna vacuna específica para el virus COVID-19, y el tratamiento está siendo de soporte con añadido de antivirales y otros fármacos, sin que hasta la fecha se haya evidenciado un beneficio claro. Muchos de estos pacientes se deterioran rápidamente y requieren ser intubados y ventilados mecánicamente, lo que está provocando el colapso del sistema sanitario en muchos países debido a la falta de ventiladores y de camas de críticos.En este documento revisamos dos terapias adyuvantes sencillas de aplicar, sin efectos deletéreos y de un coste bajo que podrían ser de utilidad para el tratamiento de la infección por coronavirus agudo severo asociado al síndrome respiratorio agudo (SARS-CoV-2). La vitamina C, un potente antioxidante, se ha convertido en una terapia relevante debido a sus beneficios potenciales cuando se administra por vía intravenosa. El efecto potencial de la vitamina C en la reducción de la inflamación en los pulmones podría desempeñar un papel clave en la lesión pulmonar causada por la infección por coronavirus. Otra posible terapia eficaz es el ozono. Pese a la controversia que siempre le ha acompañado, se ha estudiado y utilizado ampliamente durante muchos años y su eficacia se ha demostrado en múltiples estudios. Sin embargo, nuestro objetivo no es hacer una revisión exhaustiva de dichas terapias sino difundir sus efectos beneficiosos. * Autor para correspondencia. Correo electrónico: albimar23@yahoo.es (A. Hernández). Cómo citar este artículo: Hernández A, et al. Dos terapias conocidas podrían ser efectivas como adyuvantes en el paciente crítico infectado por COVID

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“…The more likely explanation though may be that due to the high case fatality of Nipah, controls were able to report exposures more completely than cases. While it is possible that sour fruits with high vitamin C content may have a protective effect against viral infection through ascorbic acid, there was no observed association between eating fruit and Nipah infection in the multivariable model of best fit (Atherton et al 1978). …”

Section: Discussionmentioning

confidence: 98%

Investigating Rare Risk Factors for Nipah Virus in Bangladesh: 2001–2012

et al. 2016

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Human Nipah encephalitis outbreaks have been identified almost yearly in Bangladesh since 2001. Though raw date palm sap consumption and person-to-person contact are recognized as major transmission pathways, alternative pathways of transmission are plausible and may not have been identified due to limited statistical power in each outbreak. We conducted a risk factor analysis using all 157 cases and 632 controls surveyed in previous investigations during 2004–2012 to identify exposures independently associated with Nipah, since date palm sap was first asked about as an exposure in 2004. To further explore possible rare exposures, we also conducted in-depth interviews with all cases, or proxies, since 2001 that reported no exposure to date palm sap or contact with another case. Cases were 4.9 (95% 3.2–7.7) times more likely to consume raw date palm sap and 7.3 (95% 4.0–13.4) times more likely to have contact with a Nipah case than controls. In-depth interviews revealed that 39/182 (21%) of Nipah cases reporting neither date palm sap consumption nor contact with another case were misclassified. Prevention efforts should be focused on interventions to interrupt transmission through date palm sap consumption and person-to-person contact. Furthermore, pooling outbreak investigation data is a good method for assessing rare exposures.

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The effect of ascorbic acid on infection of chick-embryo ciliated tracheal organ cultures by coronavirus

Abstract: Chick embryo tracheal organ cultures showed increased resistance to infection by a coronavirus after exposure to ascorbate, while chick respiratory epithelium and allantois-on-shell preparations showed no increase in resistance to infection by an influenza virus or a paramyxovirus.

Cited by 84 publications

References 18 publications

Ascorbic acid and infectious bronchitis infections in broilers

Ascorbic acid and infectious bronchitis infections in broilers

Dos terapias conocidas podrían ser efectivas como adyuvantes en el paciente crítico infectado por COVID-19

Investigating Rare Risk Factors for Nipah Virus in Bangladesh: 2001–2012

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