The effect of assisted reproductive technology on the incidence of birth defects among livebirths

Shechter‐Maor, Gil; Czuzoj‐Shulman, Nicholas; Spence, Andrea R.; Abenhaim, Haim A.

doi:10.1007/s00404-018-4694-8

Cited by 28 publications

(26 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the 29‐year period, prevalence in our hospital for ONTDs was of 12.6 per 10 000 live births (Table 1). This is notably higher compared with other prevalences based on data limited to live‐born from countries such as the United States, 22 Canada, 23 Norway, 24 and Japan, 25 which range from 2.2 to 6.9 per 10 000 live births; despite the fact that in those countries around two‐thirds of cases do not achieve birth because are electively terminated after prenatal NTDs diagnosis. It also coincides with reports indicating that our co‐nationals living in the US have intriguingly an elevated rate of NTDs in comparison with other ethnicities, 8,26 which ranges from 3.9 to 5.8 per 10 000 live births.…”

Section: Discussionmentioning

confidence: 67%

Prevalence of open neural tube defects and risk factors related to isolated anencephaly and spina bifida in live births from the “Dr. Juan I. Menchaca” Civil Hospital of Guadalajara (Jalisco, Mexico)

Corona‐Rivera

Olvera-Molina

Pérez-Molina

et al. 2020

Congenital Anomalies

View full text Add to dashboard Cite

We determine the prevalence and trends of open neural tube defects (ONTDs) during 1991 to 2019 at the “Dr. Juan I. Menchaca” Civil Hospital of Guadalajara (Mexico). Also, details of potential risks were obtained in 662 newborns, including those 143 patients with anencephaly and open spina bifida (OSB) classified as isolated (cases) and 519 controls. Data were analyzed using multivariable logistic regression. Among 267 201 live births during the study period, 336 were born with ONTDs, yielding an overall prevalence of 12.6 per 10 000. After folic acid (FA)‐related programs began in Mexico (2003‐2019), only OSB showed a decline of 20.6%. For anencephaly, associated risks included relatives with neural tube defects (NTDs) (adjusted odds ratio [aOR]: 67.9, 95% confidence interval [95% CI]: 11.3‐409.8), pre‐pregnancy body mass index (BMI) ≥25 kg/m2 (aOR: 2.6, 95% CI: 1.1‐6.0), insufficient gestational weight gain (aOR: 3.0, 95% CI: 1.3‐7.1), parity ≥4 (aOR: 3.2, 95% CI: 1.3‐7.7), and exposure to analgesic/antipyretic drugs (aOR: 9.0; 95% CI: 2.5‐33.0). For OSB, associated risks included consanguinity (aOR: 14.0, 95% CI: 3.5‐55.9), relatives with NTDs (aOR: 22.4, 95% CI: 4.5‐112.9), BMI ≥25 kg/m2 (aOR: 2.5, 95% CI: 1.6‐4.2), insufficient gestational weight gain (aOR: 1.9, 95% CI: 1.1‐3.1), and exposures to hyperthermia (aOR: 2.3, 95% CI: 1.2‐4.3), common cold (aOR: 6.8, 95% CI: 3.6‐12.7), and analgesic/antipyretic drugs (aOR: 3.6, 95% CI: 1.3‐10.0). Our high rate probably results from exposures to preventable risks, most related to FA, indicating a need for strengthening existing FA‐related programs in Mexico.

show abstract

Section: Discussionmentioning

confidence: 67%

Prevalence of open neural tube defects and risk factors related to isolated anencephaly and spina bifida in live births from the “Dr. Juan I. Menchaca” Civil Hospital of Guadalajara (Jalisco, Mexico)

Corona‐Rivera

Olvera-Molina

Pérez-Molina

et al. 2020

Congenital Anomalies

View full text Add to dashboard Cite

show abstract

“…More importantly, the birth defects most commonly associated were cyanotic heart defects, with a frequency of 0.50% in the assisted reproductive technology group and 0.07% in the spontaneous pregnancy group. 25 This is supported by another study by Shamshirsaz et al who also discovered that fertility treatments led to increased risks in the development of foetal cyanotic heart defects. 26 It is thought that along with the process of the treatment itself, the parental subfertile substrate may also be an underlying mechanism, and hence the use of assisted reproductive technology warrants screening via fetal echocardiography.…”

Section: Maternal Factorsmentioning

confidence: 81%

Sudden cardiac death in children with congenital heart disease: a critical review of the literature

et al. 2020

View full text Add to dashboard Cite

Sudden cardiac death is an uncommon but yet catastrophic event, which can occur in neonates and young children. Although extensive research has been carried out assessing the underlying causes, there still remains a degree of uncertainty around this area. Congenital heart disease (CHD) is one known cause of sudden cardiac death in children, the aetiology of which embraces virally induced mechanisms, genetic susceptibility, drug-induced, and maternal factors. Screening tools and investigations including electrocardiograms and echocardiograms alongside a concise history taking and physical examination can be used to identify the potential cardiovascular risk factors of sudden death. This review has comprehensively studied the causes and risk factors for sudden cardiac death in children with CHD and provides a collation and summary of the evidence available so far underpinning the complex link between the two. Moreover, current screening and prevention methods are discussed in detail in order to increase awareness and understanding of how we can improve patient outcomes.

show abstract

“…To date, several studies have indicated that ART use is associated with an increased risk of congenital anomalies ( 2 – 7 , 11 , 20 , 21 ). Levi et al.…”

Section: Discussionmentioning

confidence: 99%

“…Their treatment is complicated, resulting in great psychological and financial burden on the child and his family. Recently, several studies have demonstrated that pregnancies conceived with IVF/ICSI have an increased risk of congenital anomalies compared to spontaneous conceptions (3)(4)(5)(6)(7), and some meta-analyses have concluded that the pooled risk estimation ranges from 1.32 to 1.37 (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Prognosis of Congenital Anomalies in Conceptions Following In Vitro Fertilization: A Multicenter Retrospective Cohort Study in China

et al. 2022

View full text Add to dashboard Cite

BackgroundConceptions following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) have an increased risk of congenital anomalies. Few studies have explored the prognosis of fetuses with congenital anomalies. This study aimed to investigate the prevalence and prognosis of congenital anomalies in IVF/ICSI pregnancies, and to analyze the influencing factors contributing to poor prognosis.MethodsIn this multicenter retrospective cohort study, we followed 405,473 embryo transfer cycles at 15 reproductive centers between January 2010 and December 2019 and enrolled 2,006 intrauterine pregnancies with congenital anomalies. The relatively positive prognosis group with one or more live births and neonatal survival for more than 7 days was compared with the poor prognosis group with poorer outcomes.ResultsAmong the 168,270 ongoing intrauterine pregnancy cycles, the prevalence of congenital anomalies was 1.19%, wherein the malformation rates of cycles with late abortion and delivery were 2.37% (716/30,202) and 0.93% (1,290/138,068), respectively. Among all IVF/ICSI cycles with congenital anomalies, the relatively positive prognosis rate was 61.39%. Moreover, the fertilization failure rate (2 pro-nuclei rate < 25%) in the poor prognosis group was significantly higher than that in the relatively positive prognosis group (10.89% vs. 5.09%, p < 0.001). Multivariate logistic regression analysis revealed no significant differences in the relatively positive prognosis rate among the various IVF/ICSI protocols. The relatively positive prognosis rate of fertilization failure cycles was 0.180 times that of normal fertilization cycles.ConclusionPoor fertilization rates during IVF/ICSI treatments are more likely to have poor prognosis in fetuses or neonates with congenital anomalies, and obstetric management should be strengthened in pregnant women, with which pregnant women should be recommended to strengthen obstetric management.

show abstract

The effect of assisted reproductive technology on the incidence of birth defects among livebirths

Abstract: There is an overall and type-specific increased risk of birth defects in the ART population. Appropriate counseling and specialized ultrasound evaluations should be considered in pregnancies conceived by ART.

Cited by 28 publications

References 37 publications

Prevalence of open neural tube defects and risk factors related to isolated anencephaly and spina bifida in live births from the “Dr. Juan I. Menchaca” Civil Hospital of Guadalajara (Jalisco, Mexico)

Prevalence of open neural tube defects and risk factors related to isolated anencephaly and spina bifida in live births from the “Dr. Juan I. Menchaca” Civil Hospital of Guadalajara (Jalisco, Mexico)

Sudden cardiac death in children with congenital heart disease: a critical review of the literature

Prognosis of Congenital Anomalies in Conceptions Following In Vitro Fertilization: A Multicenter Retrospective Cohort Study in China

Contact Info

Product

Resources

About