The Effect of Atropine Upon the Absorption of Vitamin A

Ingelfinger, Franz J.; Moss, Robert; Helm, John D.

doi:10.1172/jci101442

Cited by 21 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such an effect resembles closely that reported by Ingelfinger, Moss, and Helm (8) in atropinized subjects fed natural vitamin A esters intraduodenally. Their studies seemed to implicate qualitative changes in digestive juices as influencing markedly the absorption of natural vitamin A esters from the intestine, but they were unable to delineate clearly the relative roles of digestive juices, intestinal motility, and other unknown factors in the absorption of vitamin A.…”

Section: Discussionsupporting

confidence: 90%

The Effects of Eating and of Sham Feeding Upon the Absorption of Vitamin a Palmitate in Man 1

Mendeloff¹

1954

J. Clin. Invest.

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

The Effects of Eating and of Sham Feeding Upon the Absorption of Vitamin a Palmitate in Man 1

Mendeloff¹

1954

J. Clin. Invest.

View full text Add to dashboard Cite

“…In humans, the role of motility in absorption of water and various solutes has long been noted. For instance, Ingelfinger et al [1943] observed that with abolition of motility by atropine in humans vitamin A absorption rate was decreased. The decrease of vitamin A absorption was apparently not due to the change of absorbing area because of the observation that when vitamin A was dispersed by water over a larger absorbing area, atropine inhibition of absorption remained.…”

Section: Discussionmentioning

confidence: 99%

ROLE OF LYMPHATIC SYSTEM IN WATER AND SOLUTE TRANSPORT FROM RAT INTESTINE IN VITRO

Lee

1969

Exp Physiol

View full text Add to dashboard Cite

The results of the present study confirm previous observations and provide further evidence that water and solute are primarily transported from the intestine by the lymphatic system of rat jejunum in vitro, regardless of the nature of the serosal bathing medium (moist air, mineral oil or Ringer solution), or degree of intestinal motility. The transport of fluid by the venous system was negligible under all circumstances so far observed. Venous transport occurred only over a brief duration but lymphatic transport continued with little diminution in rate for at least 40 min. Lymph flow decreased with the increase of mucosal fluid osmolarity but was not affected by changing serosal fluid osmolarity. Lymph was always isosmotic with the mucosal fluid whether the latter was hypo-, iso-, or hypertonic. The composition of lymph with respect to concentrations of glucose; Na, K and Cl was the same as that of the absorbed fluid. The glucose concentration in the lymph was closely related to that in the bathing fluid on the mucosal side, rather than to that on the serosal side. It is concluded that the formation of lymph in the intestine is closely associated with water and solute absorption.

show abstract

“…Reduced motility was certainly present in the small bowel of all of our patients in relapse. It has been shown by others that the absorption of glucose, methionine (13) and vitamin A (14) from the small bowel of human beings is slowed or hastened by decreases or increases in the motor action of the small intestine. Higgins, Code, and Orvis (15) have recently found that the absorption of water and sodium from the upper part of the small bowel is retarded in healthy persons when propulsive -motility is reduced or eliminated by the administration of methantheline bromide.…”

Section: Discussionmentioning

confidence: 99%

Absorption of Water and Sodium from the Small Intestine of Patients with Nontropical Sprue

Higgins¹,

Lee²,

Scholer³

et al. 1957

J. Clin. Invest.

View full text Add to dashboard Cite

There is evidence that the absorption of water from the gastrointestinal tract of patients with nontropical sprue is delayed when they have recently eaten food (1) and also when they have fasted (2, 3). Excessive fecal loss of sodium has been demonstrated in patients with nontropical sprue (4), and recently evidence obtained by the use of isotopic sodium has indicated that the absorption of sodium chloride from the small bowel of patients with this disease is delayed (5).The present study was undertaken to confirm, if possible, the presence of a defect in the absorption of water or sodium in fasting patients with nontropical sprue and to obtain a more exact measurement of its degree. The study was made possible by the recent development of a method that allows the precise quantitative determination of the rate of absorption of isotopically labeled substances from the gastrointestinal tract of human beings under completely physiologic conditions (6). METHODSFourteen patients who presented typical clinical, laboratory and roentgenographic features of nontropical sprue were studied. Three were men and 11 were women. Their ages ranged from 23 to 63 years with the majority being in the mid-thirties. Rates of absorption were determined in most of the patients on only one occasion, the majority of these being obtained during relapses of the disease. Six tests were made during remissions.A designation of the clinical status of the disease in each patient at the time the tests were performed has been used. When loss of weight, abdominal discomfort and diarrhea or any combination of such features of the disease predominated, the patient's clinical status was termed a "relapse." When such features were absent, or nearly so, the term "remission" has been used. The tests made in the course of this study fall into two groups. In the first, the rate of absorption of water alone was measured; eight such observations were made on five patients. In the second group, the rates of absorption of both water and sodium were determined. In addition to the dual determinations, refinements in methodology developed during the progress of the second part of the study allowed more precise determination of the rates of absorption of both water and sodium.The method (6) employed for estimation of the rate of absorption of a labeled substance requires determination of its rate of appearance in the arterial blood while it is being absorbed, as well as its rate of disappearance from the arterial blood stream after its rapid intravenous injection. The precise rate of absorption of the isotope is then calculated by integration of these two rates. In the past it has been necessary to employ mean rates of arterial disappearance of the isotopes as determined in a group of healthy persons (6)(7)(8), and this was the procedure adopted in the first group of observations presented in this report. While use of a mean rate of arterial disappearance has been appropriate for the study of normal human beings, since rates of arterial disappearance vary so litt...

show abstract

The Effect of Atropine Upon the Absorption of Vitamin A

Cited by 21 publications

References 18 publications

The Effects of Eating and of Sham Feeding Upon the Absorption of Vitamin a Palmitate in Man 1

The Effects of Eating and of Sham Feeding Upon the Absorption of Vitamin a Palmitate in Man 1

ROLE OF LYMPHATIC SYSTEM IN WATER AND SOLUTE TRANSPORT FROM RAT INTESTINE IN VITRO

Absorption of Water and Sodium from the Small Intestine of Patients with Nontropical Sprue

Contact Info

Product

Resources

About