The Effect of Beta-Aminopropionitrile and Prednisolone on the Prevention of Fibrosis in Alkali Esophageal Burns: An Experimental Study

Açıksarı, Kurtuluş; Yanar, Hakan; Hepgül, Gülçin; Özüçelik, Doğaç Niyazi; Yanar, Fatih; Ağcaoğlu, Orhan; Eser, Mediha; Tanrıverdi, Gamze; Topaçoğlu, Hakan; Ayvacı, Barış Murat; Doğan, Halil; Günay, Kayıhan; Ertekın, Cemalettın; Celikmen, Ferudun

doi:10.1155/2013/574260

Cited by 10 publications

(16 citation statements)

References 28 publications

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“…[9] To reduce inflammation and collagen synthesis and to prevent fibroplasia and stricture formation, many clinical and experimental studies have evaluated the medical efficiency of antioxidant and anti-inflammatory agents, such as sucralfate, palifermin, dimethyl sulfoxide, prednisolon, retinoic acid, zinc, trapidil, trimetazidine, and pentoxifylline. [9][10][11][12][13]20,21] Despite decreased stricture formations in these studies, the rate of stricture formation remained at 70%-100% in highgrade corrosive esophagitis. [9] Garlic oil, a diallyl trisulfide, is the main active constituent of garlic and is one of the oldest medicine.…”

Section: Discussionmentioning

confidence: 99%

“…Howell et al, [29] found that the steroidal treatment of corrosive esophagitis decreased the frequency of stricture formation. Aciksari et al, [13] compared the treatment effects of beta-aminopropionitrile (BAPN) and prednisolone and found that BAPN was better able to decrease the development of stenosis and tissue damage than prednisolone. In another study, [21] dimethyl sulfoxide was observed to reduce acute phase symptoms and to decrease the severity of tissue damage.…”

Section: Discussionmentioning

confidence: 99%

“…[9] Although many agents have been used in various studies to prevent the stricture development, antibiotics and steroids have only recently gained clinical approval. [10][11][12][13] Garlic oil, a diallyl trisulfide, is the main active constituent of garlic. The beneficial effects of dietary garlic have been known for centuries.…”

Section: Introductionmentioning

confidence: 99%

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Beneficial effects of garlic (Allium Sativum) oil inexperimental corrosive esophageal burns

Tanrıkulu

Tanrıkulu²,

Kılınç³

et al. 2016

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Corrosive esophageal burns, particularly common in developing countries, lead to different problems in different age groups. The ingestion of corrosive substances can cause such problems as stricture of the esophagus, to acute perforation, and even death. Because stricture formation is related to the severity of the initial injury, the prevention of stricture constitutes a main goal of treatment. The aim of this study was to investigate the protective and anti-inflammatory effects of garlic (Allium sativum) oil in corrosive esophageal burn.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Beneficial effects of garlic (Allium Sativum) oil inexperimental corrosive esophageal burns

Tanrıkulu

Tanrıkulu²,

Kılınç³

et al. 2016

Ulus Travma Acil Cerrahi Derg

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“…Numerous studies have shown that honey also suppresses free radical production [6]. There are many studies demonstrating that granulation is prevented, and stricture formation is decreased by steroidal components [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

The comparison of prednisolone and honey activities in the experimental corrosive esophagitis model

Gemici¹,

Sürek²,

Çikot³

et al. 2020

Journal of Surgery and Medicine

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This is an open access article distributed under the terms of the CreativeCommons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. AbstractAim: Honey is well known for its beneficial wound healing-related effects, including anti-edematous effects, stimulation of granulation tissue formation, chemical debridement, and immune system enhancement. In this experimental study, the effects of honey and prednisolone on stricture formation in sodium hydroxide-induced corrosive esophagitis were investigated. Methods: This study was carried out on Wistar albino rats weighing between 200-250 grams. Rats were divided into four equal groups. Corrosive esophagitis induced by 37.5% sodium hydroxide was formed in three groups. The first group received no specific treatment.The second group was treated with honey via the oral route, and the third group was treated by prednisolone intraperitoneally. The control group underwent a sham laparotomy. All subjects were sacrificed by the end of the 28 th day. A 20-mm long segment of the distal esophagus was harvested for histopathological examination. The tissue damage scores and stenosis index scores of the groups were measured and compared.Results: A total of 32 rats were included in the study, with eight subjects in each group. The mean values of stenosis index score and tissue damage score were significantly lower in the honey-treated group (P=0.001).Conclusion: Oral honey treatment seems to reduce the severity of esophageal strictures associated with corrosive esophagitis, when compared to untreated and prednisolone-treated groups. Öz Amaç: Bal antiödem etkisi, granülasyonu hızlandırıcı etkisi, enzimatik debridman ve immün sistemi güçlendirici etkisi bilinen bir doğal gıdadır. Bu deneysel çalışmanın amacı bir alkali ajan olan sodyum hidroksit ile oluşturulan koroziv özofajitte darlık gelişimi üzerine balın ve prednisolonun etkilerini araştırıldı. Yöntemler: Bu çalışma, ağırlıkları 200-250 gram arasında değişen Wistar tipi albino sıçanlar üzerinde gerçekleştirildi. Denekler, eşit sayıda dört gruba bölündü. Birinci, ikinci ve üçüncü gruplar özofajit modeli grupları olup, bu gruplardaki tüm deneklerde %37,5'luk sodyum hidroksit ile koroziv özofajit oluşturuldu. Birinci gruba herhangi bir tedavi uygulanmazken, ikici gruba oral bal tedavisi ve üçüncü gruba intraperitoneal prednisolon tedavisi uygulandı. Kontrol grubunun özofagusuna herhangi bir işlem yapılmadan şam laparotomi uygulandı. Tüm denekler 28. gün sakrifiye edildi ve deneklerin distal özofaguslarından alınan 20 mm uzunluğundaki örnekler histopatolojik incelemeye tabi tutuldu. Grupların doku hasarı skorları ve stenoz indeksi skorları ölçülerek kıyaslandı. Bulgular: Çalışmaya toplam 32 denek dahil edildi ve her bir grupta sekiz denek mevcuttu. Stenoz indeksi skoru ortalama değeri ve doku hasarı skoru ortalama değeri balla ted...

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“…[9] Although many agents, including retinoic acid, pentoxifylline, sucralfate, N-acetylcysteine, antibiotics, and steroids have been used in both clinical and experimental studies to prevent the development of strictures, only antibiotics and steroids have gained clinical application. [10][11][12][13] MB was first identified as an antimalarial agent by Ehrlich in 1981, and it has since been used in many different areas of clinical medicine including treatment of refractory distributive shock, renal stones, carbon monoxide poisoning, methemoglobinemia, and encephalopathy for years due to its low toxicity and wide availability. [14,15] Most recently, MB was described as an effective product for preventing postoperative adhesions as well.…”

Section: Introductionmentioning

confidence: 99%

The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study

Tanrıkulu

Kılınç

et al. 2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: In developing countries, esophageal burns are quite common. They are caused by the ingestion of corrosive substances that may lead to esophageal perforation in the short-term and stricture formation in the long-term. Prevention of stricture progression in the esophagus is the main aim of the treatment for corrosive esophageal burns. We aimed to investigate the protective and anti-inflammatory effects of methylene blue (MB) treatment on corrosive esophageal burns. METHODS: Twenty-eight rats were used in the study and randomly divided into four equal groups; group 1 (Sham), group 2 (control), group 3 (topical treatment), and group 4 (topical plus systemic treatment). Except for group 1 (Sham group), all three groups received sodium hydroxide (NaOH) in order to generate esophageal burns. In addition, group 2 was given normal saline, group 3 topical MB, and group 4 topical and systemic MB. RESULTS: Hydroxyproline levels were found to be lower in each of the treatment groups as compared to the control group (p=0.005 for group 3 and p=0.009 for group 4). There were no differences in the tumor necrosis factor-α (TNF-α) levels between the groups. The stenosis index (SI) in the treatment groups was also lower than the control group (p=0.016 for group 3 and p=0.015 group 4). The histopathologic damage score (HDS) was prominently lower in group 4 as compared to the control group (p=0.05). CONCLUSION: MB is effective in treating tissue damage caused by corrosive esophageal burns and in preventing esophageal stenosis. Complication rates of corrosive esophageal burns may be decreased by using MB in the initial treatment stage.

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The Effect of Beta-Aminopropionitrile and Prednisolone on the Prevention of Fibrosis in Alkali Esophageal Burns: An Experimental Study

Cited by 10 publications

References 28 publications

Beneficial effects of garlic (Allium Sativum) oil inexperimental corrosive esophageal burns

Beneficial effects of garlic (Allium Sativum) oil inexperimental corrosive esophageal burns

The comparison of prednisolone and honey activities in the experimental corrosive esophagitis model

The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study

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