The effect of body mass index on oncological and surgical outcomes in patients undergoing radical cystectomy for bladder cancer: A multicentre study of the association of urooncology, Turkey

Abstract

Objective We aimed to evaluate the effect of body mass index (BMI) on oncological and surgical outcomes in patients who underwent radical cystectomy (RC) for bladder cancer (BC). Materials and Methods We retrospectively assessed data from patients who underwent RC with pelvic lymphadenectomy and urinary diversion for BC recorded in the bladder cancer database of the Urooncology Association, Turkey, between 2007 and 2019. Patients were stratified into three groups according to the BMI cut‐off values recommended by the WHO; Group 1 (normal weight, <25 kg/m2), Group 2 (overweight, 25.0‐29.9 kg/m2) and Group 3 (obese, ≥30 kg/m2). Results In all, 494 patients were included, of them 429 (86.8%) were men and 65 (13.2%) were women. The median follow‐up was 24 months (12‐132 months). At the time of surgery, the number of patients in groups 1, 2 and 3 were 202 (40.9%), 215 (43.5%) and 77 (15.6%), respectively. The mean operation time and time to postoperative oral feeding were longer and major complications were statistically higher in Group 3 compared to Groups 1 and 2 (P = .019, P < .001 and P = .025, respectively). Although the mean overall survival (OS), cancer‐specific survival (CSS), recurrence‐free survival (RFS) and metastasis‐free survival (MFS) was shorter in cases with BMI ≥ 30 kg/m2 compared with other BMI groups, differences were not statistically significant (P = .532, P = .309, P = .751 and P = .213, respectively). Conclusion Our study showed that although major complications are more common in obese patients, the increase in BMI does not reveal a significant negative effect on OS, CSS, RFS and MFS.

Association of IL-4 and IL-1 Ra Gene Polymorphisms with the Risk of Bladder Cancer

“…Interleukin-4 (IL-4), a cytokine is produced by T cells and induces activation of B cells and lymphocytes, thus providing inhibition of angiogenesis, as well as activation of granulocytes and eosinophil, and surveillance and clearance of tumor cells (Swain et al 1990;Olver et al 2007;Izol et al 2021). IL-4 gene resides on the 5q31.1 chromosome in a cytokine gene cluster (Duan et al 2014).…”

Obesity and Complication Risk From Radical Cystectomy: Identifying a Body Mass Index Threshold

“…Despite a large body of evidence demonstrating an association between obesity and surgical morbidity, conflicting reports exist regarding complication risk from obesity subcategories. Izol 10 and Lenardis 11 et al reported that major complications are more common in obese patients than in over- and normal-weight patients after RC. At the same time, a systematic review indicated that complication risk was increased in both overweight and obese BMI categories.…”