The effect of body–mind relaxation meditation induction on major depressive disorder: A resting-state fMRI study

Abstract

, The effect of body-mind relaxation meditation induction on major depressive disorder: A resting-state FMRI study, Journal of Affective Disorders, http://dx.doi. org/10.1016/j.jad. 2015.04.030 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractBackground: Meditation has been increasingly evaluated as an important complementary therapeutic tool for the treatment of depression. The present study employed resting-state functional magnetic resonance imaging (rs-fMRI) to examine the effect of body-mind relaxation meditation induction (BMRMI) on the brain activity of depressed patients and to investigate possible mechanisms of action for this complex intervention.Method: 21 major depressive disorder patients (MDDs) and 24 age and gender-matched healthy controls (HCs) received rs-fMRI scans at baseline and after listening to a selection of audio designed to induce body-mind relaxation 2 meditation. The rs-fMRI data were analyzed using Matlab toolbox to obtain the amplitude of low-frequency fluctuations (ALFF) of the BOLD signal for the whole brain. A mixed-design repeated measures analysis of variance (ANOVA) was performed on the whole brain to find which brain regions were affected by the BMRMI. An additional functional connectivity analysis was used to identify any atypical connection patterns after the BMRMI.Results: After the BMRMI experience, both the MDDs and HCs showed decreased ALFF values in the bilateral frontal pole (BA10). Additionally, increased functional connectivity from the right dorsal medial prefrontal cortex (dmPFC) to the left dorsal lateral prefrontal cortex (dlPFC) and the left lateral orbitofrontal cortex (OFC) was identified only in the MDDs after the BMRMI.Limitation: In order to exclude the impact of other events on the participants' brain activity, the Hamilton Rating Scales for Depression (HDRS) were not measured after the body-mind relaxation induction. Conclusion:Our findings support the hypothesis that body-mind relaxation meditation induction may regulate the activities of the prefrontal cortex and thus may have the potential to help patients construct reappraisal strategies that can modulate the brain activity in multiple emotion-processing systems.

Cognitive control neuroimaging measures differentiate between those with and without future recurrence of depression

“…One possible example would be to use cognitive remediation to adjust and adapt the functioning of the CCN. A recent meta-analysis suggests that mindfulness-based cognitive therapy significantly reduces recurrence of MDD ( Kuyken et al, 2015 ; Kuyken et al, 2016 ), perhaps via improvements in Cognitive Control circuitry ( Chen et al, 2015 ; Tang et al, 2015 ).…”

Meditation effect in changing functional integrations across large-scale brain networks: Preliminary evidence from a meta-analysis of seed-based functional connectivity

“…Flowchart of the study selection process. Note: Fourteen studies from 13 publications compared meditators to controls (between-subject), postmeditation training to premeditation training (within-subject); studies from the same article were marked with "*"; Four studies (Chen et al, 2015;Farb et al, 2007;Liu et al, 2018;Taren et al, 2015) which did not include default mode network seeds were excluded from statistical analysis. FA = focused attention, OM = open monitoring, LK = loving kindness, MBSR = mindfulness-based stress reduction.…”

Work Stress and Depressive Symptoms in Fishermen With a Smoking Habit: A Mediator Role of Nicotine Dependence and Possible Moderator Role of Expressive Suppression and Cognitive Reappraisal

“…The present findings suggest the possibility that cognitive reappraisal training might have a direct positive impact on the relationship between work stress and depressive symptoms in fishermen. Prior research have proved the efficiency of intervention on cognitive reappraisal, for example, the cognitive behavioral therapy (enhancing cognitive reappraisal) could reduce the negative emotion problem by modifying cognitive reappraisal-related prefrontal cortex neural signal magnitude ( Goldin et al, 2013 ); the body-mind relaxation meditation induction could help depression patients construct reappraisal strategies ( Chen et al, 2015 ); and the brief mindful emotion awareness and cognitive reappraisal interventions could lead to large reductions in self-reported levels of negative emotion problems ( Bentley et al, 2017 ). Thus, improvements in cognitive reappraisal can be an effective way to mitigate the impact of work stress on depressive symptoms.…”