The effect of Bongardia Chrysogonum on prostate tissue in a rat model of STZ-induced diabetes

Abstract

BackgroundBongardia chrysogonum is widely used in Turkey for treating urinary tract infections and prostate hypertrophy, and it also has potent hypoglycemic effects and aids glucose homeostasis. Because of the inflammatory conditions in diabetes mellitus (DM), the prostate tissue of men with diabetes is particularly susceptible to developing hypoplasia, and DM produces characteristic pathological changes in prostate tissue. Here, we examined the effects of B. chrysogonum on the prostate tissue of rats with streptozotocin (STZ)-induced diabetes.ResultsThe glucose levels were statistically significantly higher in the diabetic rats than in healthy controls (P < 0.001). Further, they were significantly lower in the healthy and diabetic rats administered B. chrysogonum than in the untreated diabetic rats (P < 0.001 and 0.05, respectively). The total cholesterol levels were significantly lower in the healthy rats administered B. chrysogonum than the healthy controls (P < 0.05) and diabetic rats (P < 0.01). They were also significantly lower in the diabetic rats administered B. chrysogonum than those that were left untreated (P < 0.05). The testosterone levels were significantly lower in the untreated diabetic rats than in the controls (untreated ones and those administered B. chrysogonum) and diabetic rats administered the herb (P < 0.001, 0.05 and 0.01, respectively). The oxidative stress index was significantly higher in the untreated diabetic rats than the healthy controls (P < 0.05). It was also significantly lower in the healthy and diabetic groups treated with B. chrysogonum than the untreated diabetic rats (P < 0.05). Histological examination showed no changes in the prostate tissue of the non-diabetic rats. In the diabetic group, the glandular lumens were filled with cellular debris and leucocytic infiltrate, and the glandular epithelium was degenerated and thickened. In the diabetic group treated with B. chrysogonum, the epithelium was better preserved and less debris was seen in the glandular lumen.ConclusionTo our knowledge, this is the first study to histologically prove the effects of B. chrysogonum on prostate tissue in diabetes. Our findings may be useful in developing B. chrysogonum into a therapeutic agent against diabetes and benign prostate hyperplasia.

Synthesis and Characterization of Copper‐Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities

“…The hybrid nanoflower exhibited higher effective α ‐glucosidase, α ‐amylase enzymes inhibitor activities than the plain plant extract. Our results support the study of Dokuyucu et al., and the highest antidiabetic activity was found in Bongardia chrysogonum [18] …”

“…Moreover, the in vitro data demonstrated that the plant extract has anticancer and anti‐inflammatory effects [3,17] . Moreover, an in vivo study showed a positive effect in the treatment of diabetes‐induced benign prostatic hyperplasia [18] . In a scientific study, the effects on carbohydrate and fat metabolism of the decoction of the plant were evaluated.…”

The Potential Therapeutic Role of Ginkgo Biloba Extracts on the Prostate in a Rat Model of Streptozotocin-Induced Diabetes: A Histomorphometric Study

“…There was marked thickening of the fibromuscular stroma which showed a significant increase in collagen area percentage. Similar results were also recorded in previously made studies (35). It was higher incidence of benign, enlarged prostate in diabetic men than in those without diabetes.…”