The Effect of Botulinum-A Toxin in Incontinent Children With Therapy Resistant Overactive Detrusor

Hoebeke, Piet; Caestecker, Karel De; Walle, Johan Vande; Dehoorne, Joke; Raes, A.; Verleyen, Pieter; Laecke, Erik Van

doi:10.1016/s0022-5347(06)00301-6

Cited by 112 publications

(88 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reports of the application of botulin toxin to children have shown good results. Hoebeke et al 7 achieved improvement of detrusor hyperactivity in 70% of 21 patients after a single application. However, they also reported side effects in all children studied 7 .…”

Section: Resultsmentioning

confidence: 96%

“…Hoebeke et al 7 achieved improvement of detrusor hyperactivity in 70% of 21 patients after a single application. However, they also reported side effects in all children studied 7 . In a retrospective analysis of 10 children with detrusor hyperactivity of neurogenic cause treated with 3 to 5 applications of botulin toxin, Schulte-Baukloh et al 8 reported improvement of urodynamic parameters 8 .…”

Section: Resultsmentioning

confidence: 96%

See 1 more Smart Citation

Complications after bladder augmentation in children

et al. 2016

View full text Add to dashboard Cite

PURPOSE:Bladder augmentation is an effective surgical procedure for increasing bladder capacity and reducing pressure on the urinary system. It is indicated for patients with anomalies such as spina bifida, myelomeningocele, urethral valve and bladder exstrophy, who progress with low tolerance of medication. CASES:This was a retrospective study conducted on pediatric patients submitted to bladder augmentation from 2000 to 2011.RESULTS: 34 patients aged 4 to 17 years were submitted to bladder augmentation, 30 of them with an ileal loop and 4 with a ureter.A continent urinary shunt was performed in 16 patients, the Mitrofanoff conduit was associated in 15, and the Macedo technique was used in one. Mean follow-up was 34.35 months (1 to 122 months). Mean creatinine was 1.5 ng/ml (0.4 to 7.5 ng/ml) preoperatively and 1.78 ng/ml postoperatively. Three patients required a renal transplant during follow-up. There was improvement or resolution of vesicoureteral reflux in 83.5% of the kidneys on the right and in 75% on the left. Bladder capacity increased, on average, from 152.5 ml to 410 ml. The main complications were vesical lithiasis in 3 patients and conduit perforation in one. CONCLUSION:Bladder augmentation showed good results in this series, preserving renal function in most of the patients.

show abstract

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 96%

Complications after bladder augmentation in children

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Se han utilizado dosis entre 5 y 12 U/kg (52,53). El efecto es temporal, de 6 a 9 meses, y se requieren inyecciones repetidas (54). Se ha encontrado respuesta completa en 74,2 % de los hombres y 54,5 % de las mujeres y respuesta parcial en 20 % de los hombres y 18,2 % de las mujeres (55).…”

Section: Tratamiento Farmacológico Anticolinérgicosunclassified

Evaluación y tratamiento del niño con síntomas del tracto urinario inferior (LUTS)

Guerrero-Tinoco

Cano-Martínez

Vanegas-Ruiz

2018

iatreia

View full text Add to dashboard Cite

RESUMENLa disfunción miccional es un trastorno del llenado o vaciado de la vejiga en niños sin alteraciones neurológicas o anatómicas. Los síntomas del tracto urinario inferior (LUTS, por la sigla en inglés de Lower urinary tract symptoms) son un motivo frecuente de consulta con el pediatra, el nefrólogo o el urólogo pediatra, e incluso con el neurólogo y el psicólogo infantil. Se le considera una enfermedad relativamente benigna lo que en ocasiones genera desinterés entre médicos y familiares y lleva a consultas tardías e interpretación inadecuada de los síntomas. Manifestaciones como urgencia, incontinencia, enuresis, goteo posmiccional, infecciones urinarias, vulvovaginitis recurrente y constipación, en un niño sin enfermedad neurológica, deben hacer pensar al médico en disfunción miccional para enfocar oportunamente el diagnóstico, restablecer la calidad de vida del paciente, evitar las infecciones urinarias y el daño renal subsecuente e irreversible secundario a un diagnóstico tardío. Las recomendaciones actuales hacen énfasis en un enfoque menos invasivo, tratamiento conservador, manejo de la constipación y reentrenamiento vesical. Este artículo discute la evaluación, el diagnóstico y el tratamiento correctos de niños con LUTS.

show abstract

“…Hoebeke ve ark. (44) tarafından yayınlanan çalışma-da, 100 IU dozda %70 hastada kısmi veya tam yanıt bildirilmesi umut vericidir. Doza bağımlı PVR ve TAK kullanımı artışı bildirilmiştir.…”

Section: Botulinum Toxin Aunclassified

“…Çocuklarda nörojen olmayan tedaviye yanıtsız işeme disfonksiyonunda, intrasfinkterik 50-100 IU BTX-A enjeksiyonunun dissinerji ve mesane boşaltılması-na geçici olarak etki ettiği ve bunun da pelvik tabanın yeniden eğitimine izin verecek süreyle detrüsör sfinkter diskordinasyonunu engellediği gösterilmiştir (41,42,44) .…”

Section: Botulinum Toxin Aunclassified