The Effect of Breathing, Movement, and Meditation on Psychological and Physical Symptoms and Inflammatory Biomarkers in Inflammatory Bowel Disease

Gerbarg, Patricia L.; Jacob, Vinita; Stevens, Laurie; Bosworth, Brian; Chabouni, Fatiha; DeFilippis, Ersilia M.; Warren, Ryan; Trivellas, Andromahi; Patel, Priyanka V.; Webb, Colleen; Harbus, Michael; Christos, Paul J.; Brown, Richard P.; Scherl, Ellen

doi:10.1097/mib.0000000000000568

Cited by 88 publications

(104 citation statements)

References 33 publications

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“…Our results were similar to those published by Gerbarg et al in which patients with IBD that followed a Breath-Body-Mind Workshop showed lower levels of FC and CRP compared with those in the control group 41 . These authors suggest that bidirectional gut-brain inter-communication with the neural, hormonal, and immune www.nature.com/scientificreports www.nature.com/scientificreports/ system, among others is likely the mechanism underlying this association 42,43 .…”

Section: Discussionsupporting

confidence: 92%

“…More recent work has also highlighted the function of gut microbiota in IBD as well as patient responses to probiotics. In contrast, the role of psychological stress in IBD remains controversial, even though stress and/or traumatic early-life events are known risk factors for the development of this disease, and stress can exacerbate inflammation and induce disease relapses 23,[41][42][43] . Indeed, other authors have noted that patients with CD or UC experience a higher incidence of emotional disorders than the general population and that depression and anxiety can influence the prognosis and severity of these diseases 44 .…”

Section: Discussionmentioning

confidence: 99%

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The effect of a mindfulness-based therapy on different biomarkers among patients with inflammatory bowel disease: a randomised controlled trial

González-Moret

Cebolla

Cortés

et al. 2020

Sci Rep

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Mindfulness-based interventions have shown some efficacy in decreasing stress levels and improving quality of life. However, so far, only a few studies have studied this type of intervention among patients with inflammatory bowel disease and none of them have studied their effects on inflammatory biomarkers. This current study was a two-armed, single-centre, randomised (2:1 ratio) controlled trial used to evaluate the effects of a mindfulness-based intervention (n = 37) compared to standard medical therapy (n = 20) in patients with Crohn's disease or ulcerative colitis. The mindfulness intervention blended four internet-based therapy modules with four face-to-face support sessions. The outcomes we assessed were faecal calprotectin (primary outcome), C-reactive protein, and cortisol levels measured in hair samples at several timepoints. The between-group analysis highlighted significant decreases in faecal calprotectin and in C-reactive protein levels in the mindfulness-based intervention group compared to the standard medical therapy group at the six-month follow-up (faecal calprotectin: −367, [95% CI: −705, −29], P = 0.03; C-reactive protein: −2.82, [95% CI: −5.70, 0.08], P = 0.05), with moderate to large effect sizes (faecal calprotectin: ηp 2 = 0.085; C-reactive protein: ηp 2 = 0.066). We concluded that mindfulness-based therapy administered as part of standard clinical practice effectively improves inflammatory biomarkers in patients diagnosed with inflammatory bowel disease.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The effect of a mindfulness-based therapy on different biomarkers among patients with inflammatory bowel disease: a randomised controlled trial

González-Moret

Cebolla

Cortés

et al. 2020

Sci Rep

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“…Ein RCT untersuchte die Effekte eines Programms zur Atmung, Bewegung und Meditation (BBMW) im Vergleich zu einer Edukationsgruppe auf physiologische und psychologische Symptome bei 29 Patienten mit CED [760]. Die Studie kam zu dem Ergebnis, dass BBMW durchgeführt werden kann, da es zu positiven Prä-post-Effekten führt.…”

Section: Hintergrundunclassified

Aktualisierte S3-Leitlinie Colitis ulcerosa der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)

2018

Z Gastroenterol

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This guideline provides evidence-based key recommendations for diagnosis and treatment of ulcerative colitis and upgrades the 2011 version. The guideline was developed by an interdisciplinary team of gastroenterologists, surgeons, pathologists, nutrition experts, and patient support groups under the auspice of the German Society for Gastroenterology and Metabolic Diseases. The guideline used structural S3 consensus-based methodology and includes statements on clinical practice, prevention, infectiological problems, surgery and nutrition.

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“…123 In a randomized trial of 29 patients with IBD assigned to the Breath-Body-Mind Workshop (BBMW) (breathing, movement, and meditation) or an educational seminar, participation in the workshop was associated with improvements in psychological and physical symptoms, quality of life, and C-reactive protein levels. 124 Other studies have used guided imagery with relaxation training and solution-focused therapy (SFT) to demonstrate improvements in fatigue and quality of life in patients with IBD. 125–130 IBD patients with high levels of perceived stress may benefit more from this therapy than those without, as demonstrated in a trial by Jedel et al .…”

Section: Stressmentioning

confidence: 99%

Modifiable Environmental Factors in Inflammatory Bowel Disease

Burke

Boumitri

Ananthakrishnan

2017

Curr Gastroenterol Rep

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Inflammatory bowel diseases (Crohn’s disease, ulcerative colitis) are believed to arise as a result of a dysregulated immune response to commensal gut microbial flora in a genetically susceptible host. Several environmental factors may influence predisposition to disease or its natural history by modification of both the host immune response and intestinal microbial composition. Proposed environmental influences include tobacco use, diet, antibiotics, vitamin D deficiency, stress, appendectomy, and use of oral contraceptive use. Emerging epidemiologic evidence has confirmed the association of many of these factors with incident disease using prospective data. In addition, laboratory data has supported their mechanistic plausibility and relevance to intestinal inflammation. However, fewer studies have examined their impact on natural history. This article will focus on translating such evidence into clinical practice by a focus on interventional studies that have modified such environmental influences to improve disease outcomes.

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The Effect of Breathing, Movement, and Meditation on Psychological and Physical Symptoms and Inflammatory Biomarkers in Inflammatory Bowel Disease

Cited by 88 publications

References 33 publications

The effect of a mindfulness-based therapy on different biomarkers among patients with inflammatory bowel disease: a randomised controlled trial

The effect of a mindfulness-based therapy on different biomarkers among patients with inflammatory bowel disease: a randomised controlled trial

Aktualisierte S3-Leitlinie Colitis ulcerosa der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)

Modifiable Environmental Factors in Inflammatory Bowel Disease

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