The Effect of Bromfenac Sodium Nanopolymer Used in Anterior Segment of the Eye on Corneal Neovascularization

Abstract

This study was to explore the inhibitory effect of bromfenac sodium (BF) / chitosan (CS) nanoparticles (NPs) on corneal neovascularization (CNV). 45 New Zealand white rabbits provided by The First Affiliated Hospital of Jinan University were randomly divided into a control group (group A, n = 15), 0.1% BF aqueous solution treatment group (group B, n = 15), and 0.1% BF/CS-NPs suspension treatment group (group C, n = 15). A rabbit corneal alkali burn model was established. The average particle size of BF/CS-NPs with different BF concentrations was mainly 341.6 ± 12.9 nm -548.7 ± 15.4 nm; and the Zeta potential distribution was 24.3 ± 2.5 mV -35.7 ± 4.3 mV. When the initial concentration of BF was 1.5 mg/mL, the maximum drug loading was 57.35 ± 5.26%. The area of CNV in group C was significantly lower than that in groups B and A, and the differences were statistically significant (P < 0.05). At 6, 12, 18, and 24 days after surgery, the mRNA expression levels in cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) gene were compared after standardized by β-actin; group A had the highest expression level, followed by group B, and group C had the lowest expression level, showing statistically significant differences (P < 0.05). The BF/CS-NPs granules prepared in this study had stable physical and chemical properties and had a good sustainedrelease effect, and the release duration can be as long as 48 hours. BF/CS-NPs can inhibit the formation of CNV at different time points after alkali burn, and reduce the expression of VEGF and COX-2 in corneal tissue after alkali burn.

Available Therapeutic Options for Corneal Neovascularization: A Review

“…Bromfenac exerts anti-inflammatory effects by inhibiting COX-2 and blocking prostaglandin synthesis. Bromfenac inhibited corneal neovascularization formation and reduced VEGF and COX-2 expression in corneal tissue after alkali burns [47]. Additionally, bromfenac significantly decreased VEGF and monocyte chemoattractant protein-1 levels [48].…”

Update on Therapeutic Approaches to Corneal Neovascularisation

“…Bromfenac exerts anti-inflammatory effects by inhibiting cyclooxygenase 2 (COX-2) and blocking prostaglandin synthesis. Bromfenac likely inhibits the formation of corneal neovascularization and reduces the expression of VEGF and COX-2 in corneal tissue after alkali burns [20]. In addition, bromfenac also significantly decreased vascular endothelial growth factor (VEGF) level and monocyte chemoattractant protein-1 level [21].…”

Effect of sodium hyaluronate eye drop on tear film stability and tear secretion in patients with rigid gas permeable contact lens associated xerophthalmia

“…This work is licensed under the Creative Commons Attribution 4.0 International License errors and are employed globally by over 140 million people. Correspondingly, complications arising from CL usage are on the rise, including eye surface infections, conjunctivitis and dry eye syndrome [2]. Among these, dry eye syndrome is the most prevalent complication among CL wearers, leading to symptoms such as eye dryness, fatigue, burning and a sensation of foreign objects.…”

“…Among these, dry eye syndrome is the most prevalent complication among CL wearers, leading to symptoms such as eye dryness, fatigue, burning and a sensation of foreign objects. These symptoms significantly impact the daily lives and work efficiency of affected individuals [2]. In clinical practice, dry eye is often managed with artificial tears or meibomian gland massage.…”