The effect of cadmium in combination with zinc and selenium on ovarian structure in Japanese quails

Abstract

In this study the effect of cadmium, cadmium+selenium and cadmium+zinc administration on the ovarian structure in Japanese quails was studied. The morphometric analysis of the relative volume of primary follicles detected the highest value in control group with a similar value in the group with administration of cadmium with selenium. Lower relative volume is reported in group with cadmium and zinc administration and the group with simple cadmium administration (P < 0.05). The relative volume of growing follicles was very similar in all studied groups (11.33-15.35%), and the relative volume of stroma was very stable (82.59-86.45%). In the evaluation of the number of follicles undergoing atresia detected significantly higher number of atretic primary follicles as well as atretic growing follicles in the group with cadmium administration and cadmium with selenium administration in comparison with control group. In comparison of normal and atretic follicles we report the most negative effect of single cadmium administration on ovarian structure. Selenium co-administration shows protective effects but only the co-administration with zinc prevent significant cadmium ovarian alterations.

Effect of combinations of four trace elements on cadmium bioaccumulation in a few tissues of male albino rats

“…The accumulation of Cd in the tissues were as follows: kidney > liver > testis > small intestine. Several authors reported that the organ of higher accumulation of Cd is kidney and also it is a detoxifying organ (Nad et al, 2005;Linde et al, 2004 andMassanyi et al, 2003). In our study also revealed high accumulation of Cd was observed in 30d Cd treated rat kidney (31.578±0.499 µg/g) and low level of Cd concentration was observed in small intestine Table 1.…”

“…Several essential trace elements like Selenium (Se), Copper (Cu), Zinc (Zn) and Iron (Fe) participate in controlling various metabolic and signaling pathways. In vitro studies suggests there is competition for transport mechanism between Cd and some essential trace elements like Zn and Cu (Hakan et al, 2001), Se (Hijova and Nistiar, 2005) and Fe (Rodriguez-Matas et al, 1998) in rats and Zn and Se in Japanese quails (Nad et al, 2005) and calcium in suckling rats (Saric et al, 2002). Se is involved in the metabolism of glutathione (GSH) which is related to reduce toxicity of chemical carcinogen and several heavy metals.…”

“…Cadmium (Cd) is an environmental pollutant that has serious toxicity in humans and animals and causes Itai-Itai disease (Nad et al, 2005) and also induces the onset of anemia, decreases red blood cell count and hemoglobin concentration (Ognjanovic et al, 2003). Metals can not be destroyed metabolically.…”

Oxidative Stress of Cadmium-Induced Ovarian Rat Toxicity

“…The number of atretic follicles was significantly higher after Cd administration. In the other study, massanyi et al prove the negative effect of Cd on the ovarian structure [8], [9].…”

The Role Formation of Methylglyoxal, Carbonyl Compound, Hydrogen Peroxide and Advance Oxidation Protein Product Induced Cadmium in Ovarian Rat

“…Basic histological studies showed that in the ovary cadmium causes a decrease in the number of primary follicles. Massanyi et al in their research showed that the number of atretic follicles was significantly higher in all groups administered cadmium and the diameter of the follicles was significanlty smaller in the primary follicles of group C compared with control group [4], [5]. The mechanism cadmium damage the ovarium might through the formation of advance glycation end products (AGEs) by nonenzymatic reaction and the formation of advance oxidation protein products (AOPP) [6].…”