The Effect of Cadmium on the Ultrastructure and Metallothionein Levels in the Liver and Kidneys of Japanese quail

Karimi, Omid; Hesaraki, Saeed; Mortazavi, Seyyed Pejman

doi:10.29252/arakmu.12.2.21

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…Cytoplasmic vacuolation and degeneration of hepatocytes have been noticed in cypermethrin http://www.ijt.ir; Volume 12, No 4, July-August 2018 challenged rats. This derives support from the studies of other workers reported similar findings from toxicants treated mammals [4,[11][12][13][14][15][16][17][18][19], birds [20], amphibia [21] and fish [ 22,23]. Few investigators have not observed changes in liver after exposure to chlorpyrifos [24] and FYROL [25].…”

Section: Discussionsupporting

confidence: 75%

Cypermethrin-Induced Liver Histopathology in Rat: Protective Role of Jamun Seed and Orange Peel Extracts

Srivastava

Srivastava²,

Srivastav

et al. 2018

IJT

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Background: We evaluated ameliorative effects of Jamun seed and orange peel extracts on liver toxicity in cypermethrin exposed rat. Methods: Rats were given following treatments daily for 30 d: Group A: Control Group B: Rats received cypermethrin Group C: These rats received cypermethrin and Jamun seed extract simultaneously Group D: These rats received cypermethrin and orange peel extract simultaneously Group E: Rats received orange peel extract Group F: Rats received Jamun seed extract In respective groups dose of cypermethrin, Jamun seed and orange peel extract were 25 mg/ kg body wt, 200 mg/kg body wt and 200 mg/kg body wt, respectively. Liver was fixed for light and electron microscopic studies. Results: After 15 d cypermethrin or cypermethrin+JSE or cypermethrin+OPE treatment hepatocytes exhibited increased cell size, nuclei became more hyperchromatic and hypertrophied. Degeneration of nuclei and dilatation of sinusoids have been noticed. After 30 d cypermethrin treatment hepatocytes exhibit more pronounced hypertrophy with hyperchromatic nuclei. Few hepatocytes exhibit nuclei with irregular boundaries. Hepatocytes show foamy cytoplasm and few vacuoles. Focal necrosis visible at certain places. Binucleated cells are also encountered. In cypermethrin+JSE and cypermethrin+OPE treated rats, hepatocytes exhibit hypertrophy, hyperchromatic nuclei and dilatation of sinusoids. Degeneration of hepatocytes are seen at some places, however, focal necrosis is not seen in these groups. No noticeable histological alterations are seen in orange peel extract (group E) and jamun seed extract (group F) treated rats. Conclusion: Cypermethrin induced hepatic toxicity can be protected by treatment with Jamun seed and orange peel extract.

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Section: Discussionsupporting

confidence: 75%

Cypermethrin-Induced Liver Histopathology in Rat: Protective Role of Jamun Seed and Orange Peel Extracts

Srivastava

Srivastava²,

Srivastav

et al. 2018

IJT

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“…The liver exposed to cadmium undergoes vesicular fatty degeneration in the hepatic lobules and the shape of the hepatocytes transforms into a ring-like (28). Cadmium inside the hepatocytes causes swelling in both the rough endoplasmic reticulum and mitochondria, the cristae lose, nuclear chromatin presses, the fat drops increase, the liver cells disassociate with each other, and the production of metallic protein (Metallothionein) in the hepatic cells increases (29). The number of lysosomes increases, the endoplasmic reticulum is broken, the nucleus is damaged (30) the cell membrane thickens and the nuclear membrane is destroyed by cadmium (31).Cadmium toxicity damages liver cells, increases secretion of liver enzymes, and decreases concentration of antioxidant enzymes (32).…”

Section: Cadmium Toxicity In Livermentioning

confidence: 99%

“…Capillaries in the renal glomeruli and peritubular blood capillaries are congested (38). Cadmium causes cellular changes, as the mitochondria swell, the cristae lose, the nuclear chromatin is compressed, the number of ribosomes increases, the number of microvilli on the surface of the renal tubule cells decreases, and the production of metallothionein in the kidney cells increases (29). The pores of the fenestrated capillaries in the renal glomeruli close, the nuclear membrane is disturbed, the number of lysosome increases, and finally the cells die (31).…”

Section: Cadmium Toxicity In Kidneysmentioning

confidence: 99%

Cadmium Toxicity and some Target Organs: A Review

Farhan¹,

Jasim²

2020

AJVS

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Cadmium is dangerous pollutant in environment because it is difficult to excrete out of the body. It causes disease in humans and animals. When the body absorbs large quantities of cadmium or when constantly exposed to small quantities, it is toxic to the body. Cadmium affects many parts of the body, the most important of which are the liver, kidneys, lungs, and testes. Both the liver and the kidney are considered organs to excrete toxins, such as heavy metals. Therefore, they are most influenced by cadmium. This study focuses on the toxicity of cadmium in the liver, kidneys, lungs and testes and its toxic effects on the histological, cellular, and functional level of each organ. We will discuss the mechanism through which cadmium causes damage to the organs of the body and the interaction that results from it.

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“…Cadmium, which is one of the most common environmental and occupational metallic toxicants, has also been demonstrated to potentially threaten human health [1][2]. Cadmium is a potent heavy metal carcinogenic to animals [3] and humans [4]. The gonads, ventral prostate, liver and kidney are target sites for cadmium toxicity in rodents [5][6].…”

Section: -Introductionmentioning

confidence: 99%

The effectiveness of the protective role of beetroot juice for the male reproductive system of albino rats against the toxicity of cadmium chloride

AL-Janabi¹,

Shaban²,

AL-Kraie³

2019

Tikrit J. Pure Sci.

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This study was designed to evaluate the protective role of beetroot juice against the toxicity of cadmium chloride (CdCl2) in male albino rats. The study included 20 male albino rats ages ranged between (2-3 months) and weights ranged between (220-260g), which were randomly distributed into 4 groups, the first group that has been promised to control group was given distilled water, the second group was given beetroot juice 10 ml/kg b.w., group third was given at a dose of cadmium chloride 5 mg/kg b.w. for 30 days, which promised an infected control, and the fourth group were treated beetroot juice 10 ml/kg b. w. with cadmium chloride. The results showed that the treatment of animals cadmium chloride led group to a significant decrease (P ≤ 0.05) in the hormonal serum, to negative effects on of the natural shape of the sperm and to negative effects cleared on histological in testes tissues compared with the control group, In general has dosage rats treatment cadmium chloride juice of beetroot, to the positive improvement for most of the values of previous indicators has led to increase significantly, the concentration of the LH, FSH and Testosterone hormone , to an improvement in the natural shape of the sperm, decreased significantly in the form abnormal sperm, led to an improvement cleared tissue in these totals became approach with what has been observed in the control group.

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The Effect of Cadmium on the Ultrastructure and Metallothionein Levels in the Liver and Kidneys of Japanese quail

Abstract: Background: The aim of this study was to use Japanese quail as an animal model to evaluate

Cited by 4 publications

References 26 publications

Cypermethrin-Induced Liver Histopathology in Rat: Protective Role of Jamun Seed and Orange Peel Extracts

Cypermethrin-Induced Liver Histopathology in Rat: Protective Role of Jamun Seed and Orange Peel Extracts

Cadmium Toxicity and some Target Organs: A Review

The effectiveness of the protective role of beetroot juice for the male reproductive system of albino rats against the toxicity of cadmium chloride

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