The effect of caffeine on placental and fetal blood flow in human pregnancy

Kirkinen, Pertti; Jouppila, Pentti; Koivula, A.; Vuori, J.; Puukka, M.

doi:10.1016/0002-9378(83)90250-8

Cited by 157 publications

(122 citation statements)

References 7 publications

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“…In a study conducted on 1001 women in Yugoslavia, a significant reduction in birth weight was associated with an average caffeine intake of 471 mg/day or more, but only in infants born to no-smoking mothers (Kirknen et al, 1983). In the present study, the effect of caffeine was not affected by smoking, thus not supporting any interaction.…”

Section: Resultscontrasting

confidence: 59%

Maternal coffee drinking in pregnancy and risk of small for gestational age birth

et al. 2004

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Objective: We have analysed the association between coffee drinking before and during the three trimesters of pregnancy and risk of small for gestational age (SGA) birth. Methods: Cases were 555 women who delivered SGA births (ie o10th percentile according Italian standard). The controls included 1966 women who gave birth at term (Z37 weeks of gestation) to healthy infants of normal weight. Results: In comparison with nondrinkers, the ORs for SGA birth were 1.3 (95% confidence interval, CI, 0.9-1.9) for consumption of four or more cups of coffee/day before pregnancy, and 1.2 (95% CI 0.8-1.8), 1.2 (95% CI 0.8-1.8) and 0.9 (95% CI 0.6-1.4) for consumption of three or more cups of coffee/day during the first, second and third trimester of pregnancy, respectively. Conclusion: These findings were consistent in women who delivered preterm and at term births and were not affected by potential confounding such as smoking.

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Section: Resultscontrasting

confidence: 59%

Maternal coffee drinking in pregnancy and risk of small for gestational age birth

et al. 2004

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“…The most commonly known sources of caffeine are coffee, cocoa beans, kola nuts, and tea leaves, but at least 63 plant species worldwide present compounds known as methylxanthines like caffeine (1, 3, 7-trimethylxanthine) 7 . Importantly, caffeine as a hydrophobic compound is able to pass through the placenta, reaching the fetus 8 .…”

Section: Introductionmentioning

confidence: 99%

The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption

et al. 2014

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PURPOSE:To investigate the effects of the maternal caffeine consumption during pregnancy to adult male testis mice offspring. METHODS:Twenty pregnant mice were divided into control group (c) and caffeine group (cf). dams received daily saline or 20 mg/kg of caffeine subcutaneously. Male offspring were monitored daily until 13 th week. The testis were used to evaluate both the proliferation (pcna) and apoptosis (bax); leptin receptor (ob-r); aromatase; follicle stimulating hormone (fshr), luteinizing hormone (lhr) and androgen receptors (ar); steroidogenic acute regulatory protein (star); vascular endothelial growth factor (vegf) and estrogen receptors (erα and erβ) by western blotting. Serum concentrations of testosterone, estradiol and leptin were measured. RESULTS:There was a significant reduction in food intake and the body mass gain (p<0.05) in the cf ; pcna (p=0.01), fshr (p=0.02), star (p=0.0007), vegf (p=0.009), ar (p=0.03) in the cf. while an increase were note in bax (p=0.01), ob-r (p=0.02), lhr (p=0.04) and in the aromatase (p=0.03) in the cf. only erα and erβ were not changed by maternal caffeine. The serum testosterone levels in the cf offspring were 90% lower than in the c offspring (p=0.04). CONCLUSION:Maternal caffeine consumption has a role and alters the testis of the offspring in adulthood.

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“…The rate of caffeine metabolism decreases from the first to third trimester and the half-life of caffeine doubles in the mother during pregnancy (10,11) , leading to higher exposure for the fetus to maternally ingested caffeine. Exposure to caffeine may lead to vasoconstriction in the uteroplacental circulation, which can in turn affect fetal growth and development (12,13) . Spontaneous abortion and stillbirth may have different underlying physiology and risk factors.…”

mentioning

confidence: 99%

Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

Chen

Neelakantan

et al. 2015

Public Health Nutr.

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Objective: To assess the association between maternal caffeine intake and risk of pregnancy loss using a systematic review and meta-analysis. Design: Categorical and dose-response meta-analysis of prospective studies. Setting: Relevant articles were identified by searching MEDLINE and SCOPUS databases through 30 January 2015. Two authors independently extracted information from eligible studies. Random-effects models were used to derive the summary relative risks (RR) and corresponding 95 % CI for specific categories of caffeine consumption and for a continuous association using generalized leastsquares trend estimation. Subjects: A total of 130 456 participants and 3429 cases in fourteen included studies. Results: Compared with the reference category with no or very low caffeine intake, the RR (95 % CI) of pregnancy loss was 1·02 (0·85, 1·24; I 2 = 28·3 %) for low intake (50-149 mg/d), 1·16 (0·94, 1·41; I 2 = 49·6 %) for moderate intake (150-349 mg/d), 1·40 (1·16, 1·68; I 2 = 18·6 %) for high intake (350-699 mg/d) and 1·72 (1·40, 2·13; I 2 = 0·0 %) for very high intake (≥700 mg/d). In the dose-response analysis, each 100 mg/d increment in maternal caffeine intake (~1 cup of coffee) was associated with 7 % (95 % CI 3 %, 12 %) higher risk of pregnancy loss. Our results may have been affected by publication bias, but the association remained significant for the subset of larger studies. Furthermore, adjustment for smoking and pregnancy symptoms may have been incomplete, potentially resulting in residual confounding. Conclusions: Albeit inconclusive, higher maternal caffeine intake was associated with a higher risk of pregnancy loss and adherence to guidelines to avoid high caffeine intake during pregnancy appears prudent.

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The effect of caffeine on placental and fetal blood flow in human pregnancy

Cited by 157 publications

References 7 publications

Maternal coffee drinking in pregnancy and risk of small for gestational age birth

Maternal coffee drinking in pregnancy and risk of small for gestational age birth

The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption

Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

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