The Effect of Calcium Dobesilate on Liver Damage in Experimental Obstructive Jaundice

Ünal, Yasemin; Tuncal, Salih; Koşmaz, Koray; Küçük, Berkay; Kısmet, Kemal; Çavuşoğlu, Turgut; Çelepli, Pınar; Şeneş, Mehmet; Yıldız, Selin; Hücümenoğlu, Sema

doi:10.1080/08941939.2018.1451936

Cited by 16 publications

(19 citation statements)

References 22 publications

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“…Calcium dobesilate (CaD) is an established vasoactive and angioprotective drug (Doxium ® , OM PHARMA, Meyrin, Switzerland) commonly used to treat diabetic retinopathy and chronic venous insufficiency, reducing vascular permeability [ 11 , 12 ]. Previous studies also reported the antioxidant properties of CaD [ 13 , 14 ]. It is a potent free radical scavenger in the retina and reduces the level of malondialdehyde (MDA), inhibiting lipid peroxidation [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress

et al. 2021

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The long-term treatment of mice with D-galactose (D-gal) induces the overproduction of reactive oxygen species (ROS) and is a well-accepted experimental model of oxidative stress-linked cognitive disorders in physiological aging. Calcium dobesilate (CaD, Doxium®) is an established vasoactive and angioprotective drug commonly used for the clinical treatment of diabetic retinopathy and chronic venous insufficiency. It has antioxidant properties and controls vascular permeability. In the current study, we evaluated the protective effects of CaD (50 and 100 mg/kg/day p.o.) in male mice treated with D-gal (500 mg/kg/day p.o.) for six weeks. Results demonstrated that body weight loss, anxiety-like and cognitive impairments of D-gal-treated animals were reversed by CaD administration as evaluated by the measurement of mice performance in elevated plus-maze, Y-maze, and shuttle box tests. CaD treatment also inhibited the oxidative stress in aging mouse brains by decreasing malondialdehyde (MDA) levels and increasing superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) enzyme activities. These results could open new perspectives for the clinical use of CaD in treating and preventing cognitive impairment in older people.

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Section: Introductionmentioning

confidence: 99%

“…Previous studies also reported the antioxidant properties of CaD [ 13 , 14 ]. It is a potent free radical scavenger in the retina and reduces the level of malondialdehyde (MDA), inhibiting lipid peroxidation [ 14 ]. Moreover, CaD increases the activity of antioxidant enzymes [ 13 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress

et al. 2021

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“…It can cause damage to various tissues and organs in the body with the most serious leading to hepatic injury. Studies have demonstrated that the accumulation of inflammatory factors in liver tissues and abnormal serum biochemical indexes are important causes of hepatic injury (1)(2)(3). However, the specific mechanism of hepatic injury caused by OJ remains not fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Dexmedetomidine activates the PI3K/Akt pathway to inhibit hepatocyte apoptosis in rats with obstructive jaundice

et al. 2019

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Obstructive jaundice (OJ) is a common disease in clinical surgery. The present study aimed to determine the effects of dexmedetomidine (Dex) on hepatocyte apoptosis in rats with OJ and also to explore the underlying mechanism. A total of 30 adult male Sprague Dawley rats were randomly divided into 3 groups: Sham group, bile duct ligation (BDL) group, and BDL+Dex group. The serum liver function index, expression levels of serum inflammatory factor interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), and the liver pathological changes were compared amongst groups. The serum liver function index and expression levels of inflammatory factors in the BDL group and BDL+Dex group were higher compared with the sham group. The serum liver function index and expression levels of inflammatory factors were lower in the BDL+Dex group compared with the BDL group. The severity of hepatic injury was diminished in the BDL+Dex group compared with the BDL group. Compared with the sham group, the hepatocyte apoptosis rate increased significantly in the BDL group and BDL+Dex group. The present findings suggested that Dex improved the liver function of rats with OJ, reduced the production of inflammatory factors and inhibited the apoptosis of hepatocytes. Dex demonstrated a protective effect on liver damage potentially via activation of the phosphoinositide 3-kinase/protein kinase B signaling pathway.

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“…In the literature, many experimental studies have been conducted with various drugs with antioxidant and anti-inflammatory properties to treat the damage caused by OJ. In an experimental study of OJ, Unal et al reported that Calcium Dobecylate significantly reduced the development of inflammation and fibrosis in the liver, and that serum and tissue enzyme activity decreased biochemically and oxidative stress significantly (20). Moran et al demonstrated that nitric oxide (NO) plays a crucial role in inducing liver damage in rats with jaundice and that erythropoietin reduces oxidative damage both by decreasing NO levels and increasing or possibly preserving reduced glutathione levels (6).…”

Section: Discussionmentioning

confidence: 99%

Does red ginseng ameliorate liver damage caused by obstructive jaundice? : an experimental study

Durhan¹,

Koşmaz²,

Şenlikçi³

et al. 2021

Journal of Health Sciences and Medicine

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Aim: This experimental study aimed to evaluate the hepatoprotective effect on obstructive jaundice (OJ) of oral Red Ginseng (RG) extract, which is known to have anti-inflammatory and antioxidant properties. Material and Method: The rats were randomly separated into 3 groups of 10 rats: The sham group, the control group, and the treatment group. In Group 1 (sham), the common bile duct (CBD) was identified but no ligation or transection was performed. In Group 2 (control), the CBD was identified and ligation and transection were performed, but no treatment was given. In Group 3 (RG group), CBD ligation and transection were performed, then RG extract was administered via an orogastric tube at a dose of 100 mg/ kg/day for 10 days. After 10 days, blood samples were taken for biochemical analysis, and liver tissue samples for biochemical and histopathological analysis. Results: Significantly higher serum albumin levels and lower serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in the RG group than in the control group (p=0.028, p=0.001 and p=0.034, respectively). In the oxidative stress parameters, malondialdehyde (MDA) levels and catalase (CAT) levels were significantly different between the RG group and control group (p≤0.001 for each). Total sulfhydryl (T-SH) was not at a statistically significant level, although it was high and approached the value of the sham group (p=0.076). In the histopathological evaluation, the RG group had statistically significantly lower scores in all parameters compared to the control group (p<0.05). Conclusion:The results of this study showed that RG has a strong hepatoprotective effect as a result of its anti-inflammatory and antioxidant properties.

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The Effect of Calcium Dobesilate on Liver Damage in Experimental Obstructive Jaundice

Abstract: CaDob treatment repaired the histpatological changes induced by bile duct ligation. The hepatoprotective effects of CaDob can be associated with its antioxidant properties of the drug.

Cited by 16 publications

References 22 publications

Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress

Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress

Dexmedetomidine activates the PI3K/Akt pathway to inhibit hepatocyte apoptosis in rats with obstructive jaundice

Does red ginseng ameliorate liver damage caused by obstructive jaundice? : an experimental study

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