The Effect of Cannabis Sativa Leaves Aqueous Extract on Cerebral Cortex in Albino Rats

Amaza, Danladi Sambo

doi:10.9790/0853-0625358

Cited by 2 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experimental Procedure: The 40 Wistar rats with an average weight of 110g were randomly divided into 5 groups (8 rats each). A low dose and high dose of 250mg/kg and 900mg/kg respectively and a normal dose of 750mg/kg of aqueous marijuana were used according to research conducted by Danladi, et al [10] to induce the rat. The dosage of lemon zest used includes 250mgkg…”

Section: Collection and Accumulation Of Cannabismentioning

confidence: 99%

Ameliorating Potentials of Lemon Zest on Pons Neurons in Canabis sativa-Induced Wistar Rat

Yorkum

Bob-Manuel

2023

AJARR

View full text Add to dashboard Cite

Cannabis sativa, commonly known as marijuana has been indicated for many organs malfunction. It is a common plant ingested or taken by people or individuals for body enhancement. The purpose of this study is to determine the effects of lemon zest on the pons of cannabis sativa induced Wistar rats. The plant was collected from National Drug Law Enforcement Agency (NDLEA), Rivers State, Nigeria and 40 healthy Wistar rats were used for the experiment. The rats were divided into five (5) groups. Group 1 served as control, groups 2,3,4 and 5 served as 250 mg/kg lemon zest only, 750mg/kg cannabis sativa only, 500 mg/kg cannabis sativa + 250 mg/kg lemon zest and 900mg/kg cannabis sativa +250 mg/kg lemon zest respectively. The plant extract was administered for 21 days, and thereafter, the organs were harvested for routine histological tissue processing. Findings from the study revealed that when 500mgkg-1 of Cannabis sativa was used to induce the pons, observation showed neuronal hypertrophy and degeneration with mobilization of several supporting cells. The connective tissue indicated an edematous appearance. It was also observed that when a low dosage (500 mgkg-1) of the cannabis sativa was administered alongside 250 mgkg-1 extract of lemon zest, well delineated neuronal cells with well-defined nuclei and nucleolus were observed in the tissue. When the dosage of the Cannabis sativa was increased to 900 mgkg-1 alongside 250mgkg-1 extract of lemon zest, pockets of edematous connective tissues and blood vessel congestion were still noticeable in the tissue. There was a general recovery (proliferation) of lost cells in groups 4 and 5 respectively, as a consequence of the administration of lemon zest with extract (Cannabis sativa) on Wistar rat. The improved tissue and cellular appearance are indications of the potency of lemon zest in the amelioration of adverse tissue effects introduced by the extract of Cannabis sativa.

show abstract

Section: Collection and Accumulation Of Cannabismentioning

confidence: 99%

Ameliorating Potentials of Lemon Zest on Pons Neurons in Canabis sativa-Induced Wistar Rat

Yorkum

Bob-Manuel

2023

AJARR

View full text Add to dashboard Cite

show abstract

Cannabis Effects on the Visual Cortex Hisotarchitecture of Wistar Rats

Desalu

Owolabi

Adeyemo

et al. 2017

AJMAH

View full text Add to dashboard Cite

Cannabis is the most widely abused illegal substance in many countries of the world presently. It acts on the higher nerve centers and produces a feeling of intoxication with hallucination. Its main component, delta-tetrahydrocannabinol, produces the 'high' feeling that most users crave. Adolescence is the age of continued neuromaturation and most users experiment at the adolescent age. The aim of this research is to evaluate the histological effects of Cannabis sativa on the visual pathway of adolescent Wistar rats. A total of twenty-four (24) adolescent Wistar rats were recruited primarily for this study. They were randomly divided into four groups of six rats each labelled A, B, C, D which include the Control, Low Dose Group, Medium Dose Group and High Dose Group respectively. Administration lasted for 21 days with the Control group being administered pelletized rat chow and clean water ad libitum, the Low Dose group being administered 150 mg/kg body weight of the rat, the Medium Dose group being administered 250 mg/kg body weight of the rats and the High Dose group being administered 500 mg/kg body weight of the rats. At the end of the Original Research Article

show abstract

The Effect of Cannabis Sativa Leaves Aqueous Extract on Cerebral Cortex in Albino Rats

Cited by 2 publications

References 7 publications

Ameliorating Potentials of Lemon Zest on Pons Neurons in Canabis sativa-Induced Wistar Rat

Ameliorating Potentials of Lemon Zest on Pons Neurons in Canabis sativa-Induced Wistar Rat

Cannabis Effects on the Visual Cortex Hisotarchitecture of Wistar Rats

Contact Info

Product

Resources

About