The effect of carboxylic acids on glycine polymorphism, salt and co-crystal formation. A comparison of different crystallisation techniques

Losev, Evgeniy A.; Михайленко, М. А.; Achkasov, A. F.; Boldyreva, Elena V.

doi:10.1039/c3nj41169a

Cited by 54 publications

(45 citation statements)

References 78 publications

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“…The studies have revealed that carboxylic acid used as additive can affect phase transformation and physical properties such as crystal shape, particle size, fluidity, and dispersion or agglomeration behavior of the glycine crystals. Therefore, among the various types of carboxylic acids, propane‐1, 2, 3‐tricarboxylic acid was preferred in the current study due to its cost effectiveness, high efficiency, availability and easy handling . The experiments were carried out at 500 ppm additive concentration.…”

Section: Experimental Methodsmentioning

confidence: 99%

Impacts of UV Radiation on the Polymorphic Transformation of β Glycine to α Glycine

Polat

2017

Crystal Research and Technology

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The influence of UV radiation on the phase transformation of β glycine to α glycine was investigated at 25°C in the absence and the presence of varying intensities of UV radiation. The transformation of the polymorph was monitored by continuously measuring the ultrasonic velocity in the crystallizer, and the crystals obtained were analyzed using XRD to determine the polymorphic form. In addition, the crystals were characterized by SEM, a particle sizer and ATR-FTIR. The results indicated that the UV radiation and its intensity have significant effects on the both the average particle size and the morphology of glycine crystals. To further understand the role of UV radiation and its intensity on glycine phase transformation, these experiments were also performed in the presence of propane-1,2,3-tricarboxylic acid. It was found that the presence of the additive in the crystallization media caused the transition time to be extended; however, the presence of both the additive and UV radiation lessened the phase transformation time significantly, depending on the increase in UV radiation intensity. In addition, TGA-MS results revealed that the amount of evolved gases in the presence of UV radiation was reduced, and that the UV radiation caused changes in the glycine.

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Section: Experimental Methodsmentioning

confidence: 99%

Impacts of UV Radiation on the Polymorphic Transformation of β Glycine to α Glycine

Polat

2017

Crystal Research and Technology

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“…The knowledge is required for the design of particles containing AAs and is generally deduced from their crystallization and drying behaviors. The involvement of both drying and crystallization processes in spray drying of AAs means that it is challenging to understand these behaviors separately (Maas et al, 2011;Littringer et al, 2013), and has resulted in limited works being done in this area (Yu and Ng, 2002;Penović et al, 2013;Losev et al, 2013). To study the crystallization process during drying, the well-defined systems of Single Droplet Drying (SDD) and Micro Fluidic Jet Spray Drying (MFJSD) at the Monash research group were employed to examine the crystallization behaviors of mixed AAs -taurine and glycine (Lin et al, 2015;Lin et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Spray drying of mixed amino acids: The effect of crystallization inhibition and humidity treatment on the particle formation

Lin

Woo

et al. 2017

Chemical Engineering Science

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“…Studies have shown that polymorphism can be controlled by adding additives to the crystallization medium. NaCl, different types of carboxylic acids and fatty acids, such as lauric and butyric acid, are some of the additives that have been investigated to date.…”

Section: Introductionmentioning

confidence: 99%

An experimental investigation and kinetic‐modeling study of the phase transformation behavior of glycine in various carboxylic acids

Polat

Sayan

2019

Asia-Pacific J Chem Eng

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In this study, the phase transformation behavior from β-glycine (Gly) to α-Gly was examined in the presence of three different carboxylic acid additives (acetic, tartaric, and citric acid) at three different concentrations. Initially, the structure, morphology, shape parameters, surface functional groups, and elemental properties of the crystals prepared from the additive-containing and nonadditive media were investigated. The characterization results showed that when compared with the pure medium, both the duration of the phase transformation and physicochemical properties of the α-Gly crystals were altered in the presence of the three carboxylic acid additives studied. Subsequently, the experimental data obtained from the thermogravimetric analysis of the α-Gly samples obtained from the additive containing and nonadditive media were modeled using a simplified DAEM kinetic model. On the basis of the data obtained from the distributed activation energy model, the average activation energy for the Gly crystals obtained from the pure medium was calculated to be 90.8 kJ/mol. The value for the crystals obtained from the acetic acidcontaining medium was 104.0 higher than that found for the crystals from the pure medium and other two other additives studied. Besides kinetic analysis, thermogravimetric analysis/Fourier-transform infrared spectroscopy and elemental analysis confirmed that the carboxylic acid was adsorbed on the crystal's surface. The amount of acetic, tartaric, and citric acid adsorbed was 2.97, 2.38, and 1.72 mg/g, respectively.

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The effect of carboxylic acids on glycine polymorphism, salt and co-crystal formation. A comparison of different crystallisation techniques

Cited by 54 publications

References 78 publications

Impacts of UV Radiation on the Polymorphic Transformation of β Glycine to α Glycine

Impacts of UV Radiation on the Polymorphic Transformation of β Glycine to α Glycine

Spray drying of mixed amino acids: The effect of crystallization inhibition and humidity treatment on the particle formation

An experimental investigation and kinetic‐modeling study of the phase transformation behavior of glycine in various carboxylic acids

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