1982
DOI: 10.1111/j.1476-5381.1982.tb09350.x
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The Effect of Chemical Sympathectomy on Mitochondrial Function in the Ischaemic and Reperfused Myocardium

Abstract: 1 Isolated rabbit hearts were perfused aerobically for 120 min, made ischaemic for 90 min, or made ischaemic for 90 min and then reperfused for 30 min. 2 Some rabbits were pretreated with 6-hydroxydopamine (6-OHDA), given as three separate intravenous doses of 30, 20 and 20mg/kg, 20 to 48 h before they were killed; others (controls) received saline according to the same regime. 3 Mitochondria were harvested from left ventricular homogenates and their function assessed by measuring state 302 consumption (state … Show more

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Cited by 11 publications
(6 citation statements)
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“…Peak developed tension was detected by means of a Narco F-60 Biosystem myograph attached to the left ventricular apex (Nayler & Scott, 1982). The output from the strain gauge was displayed on a Devices Physiograph recorder (Narco Biosystems, Houston, Texas).…”
Section: Methodsmentioning
confidence: 99%
“…Peak developed tension was detected by means of a Narco F-60 Biosystem myograph attached to the left ventricular apex (Nayler & Scott, 1982). The output from the strain gauge was displayed on a Devices Physiograph recorder (Narco Biosystems, Houston, Texas).…”
Section: Methodsmentioning
confidence: 99%
“…For instance, in other studies prolonged oral treatment with other verapamil types of calcium antagonists has depleted left-ventricular norepinephrine reserves [7,37,38]. Decreased availability of catecholamines during ischemia will reduce ischemic damage and will improve recovery on reperfusion [39]. At present, however, there are no indications of whether anipamil treatment has any effect on the cardiac norepinephrine stores.…”
Section: Mechanism Of Protectionmentioning
confidence: 96%
“…Peak developed and resting tension were continuously monitored using a Grass FT03 transducer attached to the ventricular apex and recorded on a Narco Bio-Systems Physiograph MK-IV (14,16). Peak developed tension is defined as the difference between peak systolic and resting tension.…”
Section: Mechanical Function Stuchesmentioning
confidence: 99%
“…The hearts were rapidly excised, placed in ice-cold Krebs-Henseleit buffer solution and mounted on a Langendorff perfusion apparatus as previously described (14,16). The Krebs-Henseleit buffer contained, in mmol/l: NaC1, 124; KC1, 4.7; CaCI2, 2.6; MgC12, 1.0; NaHCO3, 24.0; NaH2PO4, 0.5; glucose, 11.0; it was gassed with 95 % 02 + 5 % COz and delivered to the heart at a temperature of 37 ~ The hearts were allowed to beat spontaneously and were surrounded by water-filled, temperature controlled jackets.…”
Section: Perfusionmentioning
confidence: 99%