The Effect of Chemical Sympathectomy on Insulin-Stimulated Gastric Secretion in Dogs

Grabner, P.; Holian, Oksana; Kalahanis, N. G.; Grabner, E. Torma; Bombeck, C. Thomas; Nyhus, Lloyd M.

doi:10.1080/00365521.1984.12005706

Cited by 9 publications

(1 citation statement)

References 18 publications

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“…Chemical sympathectomy with 6-OHDA causes complete sympathectomy of the gastric mucosa (Thoenen and Tranzer, 1968). As sympathetic innervation of the stomach inhibits gastric-acid secretion, chemical sympathectomy resulted in a highly significant increase in gastric-acid secretion (Grabner et al, 1984). Larson et al (1984 reported that chemical sympathectomy increased acid secretion in response to submaximal doses of pentagastrin.…”

Section: And Palmer and Humphreysmentioning

confidence: 99%

Inhibitions by 6‐hydroxydopamine and neostigmine singly or together of gastric carcinogenesis induced by N‐methyl‐N′‐nitro‐n‐nitrosoguanidine in wistar rats

Tatsuta

Baba

Taniguchi

1992

Intl Journal of Cancer

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The effects of chemical sympathectomy induced by 6-hydroxydopamine (6-OHDA) and administration of the acetylcholinesterase inhibitor neostigmine, singly or together, on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and on the tissue catecholamine concentration of the gastric wall and the labeling index of the gastric mucosa, were investigated in inbred Wistar rats. Rats received s.c. injections of neostigmine (0.075 mg/kg), and/or i.p. injections of 6-OHDA (42 mg/kg twice within 24 hr, and then 105 mg/kg every 2 weeks from 1 week later) 25 weeks after oral treatment with MNNG. Prolonged administration of 6-OHDA or neostigmine significantly reduced the incidence of gastric cancers by week 52, and in combination they had a significantly greater inhibitory effect. 6-OHDA and/or neostigmine had no influence on the histology of gastric cancers. Administration of 6-OHDA, but not neostigmine, significantly decreased the norepinephrine concentration in the antral portion of the gastric wall. The labeling index of the antral mucosa was decreased significantly by treatment with 6-OHDA or neostigmine, and decreased even more significantly by 6-OHDA plus neostigmine. Our findings indicate that 6-OHDA and neostigmine have protective effects against gastric carcinogenesis and that in combination their effects are additive. These results imply that the activities of the sympathetic and parasympathetic autonomic systems together influence gastric carcinogenesis.

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Section: And Palmer and Humphreysmentioning

confidence: 99%

Inhibitions by 6‐hydroxydopamine and neostigmine singly or together of gastric carcinogenesis induced by N‐methyl‐N′‐nitro‐n‐nitrosoguanidine in wistar rats

Tatsuta

Baba

Taniguchi

1992

Intl Journal of Cancer

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Glucagon and Glucagon‐like Peptide Production and Degradation

Kieffer

Hussain

Habener

2001

Comprehensive Physiology

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The sections in this article are: History Glucagon Glucagon‐like Peptides The Glucagon Superfamily of Peptide Hormones Tissue Distribution of Proglucagon Expression Pancreas Intestine Brain Proglucagon Biosynthesis Organization and Structure of the Proglucagon Gene Regulation of Glucagon Gene Expression Posttranslational Processing of Proglucagon Chemistry and Structure Regulation of Glucagon Secretion Overview Intracellular Signals Nutrients Endocrine/Paracrine Neural Pulsatility Regulation of Glucagon‐like Peptide‐1 Secretion Overview Intracellular Signals Nutrients Endocrine Neural Metabolism and Degradation Overview Renal Clearance Hepatic Clearance Degradation in the Circulation Biologically Active Fragments Physiological Actions Glucagon Glucagon‐like Peptide‐1 Glucagon‐like Peptide‐2 Mechanisms of Action Glucagon Glucagon‐like Peptide‐1 Glucagon‐like Peptide‐2 Human Disease Glucagon Glucagon‐like Peptide‐1 Glucagon‐like Peptide‐2

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