The effect of chemotherapy on nutritional status and weakness in geriatric gastrointestinal system cancer patients

Bıçaklı, Derya Hopancı; Özveren, Ahmet; Uslu, Rüçhan; Dalak, Reci Meseri; Cehreli, Ruksan; Karabulut, Bülent; Akçiçek, Fehmi

doi:10.1016/j.nut.2017.09.013

Cited by 24 publications

(21 citation statements)

References 24 publications

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“…The study by Bicakli et al [17] is very similar to our work, altough they have included all gastrointestinal tract malignancies, not only the patients with CRC. They have found similar results that malnutrition is very common in the geriatric cancers group, and even one course of CT significantly increased the rate of malnutrition in geriatric patients with gastrointestinal malignancy.…”

Section: Discussionsupporting

confidence: 71%

The Effect Of Chemotherapy On Malnutrition In Geriatric Group With Metastatic Colorectal Cancer

Namal¹

2018

South Clin Ist Euras

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Objective: Malnutrition in geriatric patients with colorectal cancer (CRC), especially those who received chemotherapy (CT), is a frequent condition. The aim of this study was to determine the effect of CT on malnutrition in patients with geriatric metastatic CRC (mCRC). Methods:A total of 136 patients aged 70 years and older, and diagnosed with mCRC, were enrolled in the study. The nutritional status of the patients was evaluated with the Nutritional Risk Score-2002 before CT and after one CT course.Results: The median follow-up time was 18.5 months. The median age was 74. The ECOG performance score of all patients was 0 or 1. 62.5% had liver metastasis, 26% had lung metastasis, 25% peritoneal metastasis, and 8% bone metastasis. It was determined that 17.3% of patients were malnurished, and 24.6% had a risk of malnutrition. 49.4% of patients with pre-CT weight loss have begun. The average weight loss before the first CT was 12.1%, and the incidence of malnutrition after one course of CT was 46.4% (p=0.001). Conclusion:Malnutrition is frequently observed in patients with geriatric mCRC, and even a single course of CT increases malnutrition in patients.

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Section: Discussionsupporting

confidence: 71%

The Effect Of Chemotherapy On Malnutrition In Geriatric Group With Metastatic Colorectal Cancer

Namal¹

2018

South Clin Ist Euras

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“…The exclusion criteria were as follows: patients <65 years, pacemakers, significant ascites, edema, inability to stand up, and hearing and perception problems. Weakness status of these patients was published previously (11). This paper produced seconder analysis from original data of the same patients.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of sarcopenia, sarcopenic obesity, and phase angle in geriatric gastrointestinal cancer patients: before and after chemotherapy

Bıçaklı¹

2019

Turk J Med Sci

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Background/aim: The purpose of this study was to determine sarcopenia, sarcopenic obesity and phase angle (PA) and the influence of chemotherapy (CT) on anthropometric measurements and and the PA in in geriatric patients with gastrointestinal (GI) cancer. Material and methods: The anthropometric measurements, calf circumference (CC), upper midarm circumference (UMAC), and hand grip strength (HGS), have been measured to understand muscle function of 153 patients (mean age of 70.5 ± 5.6 years, 28.8% female, 71.2% male). Sarcopenia and PA measurements have been evaluated by bioelectrical impedance analyses. The same evaluations were checked again after 1 cycle of CT (min: 4, max: 6 weeks). Results: Patient population consisted of colorectal (51,6%), gastric (26.8%), pancreas (11.8%), liver (7.2%), and biliary tract cancer (2%).

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“…Median follow-up period from the date of nutritional evaluation was 4 months [95% confidence interval (CI), [1][2][3][4][5][6][7][8][9][10][11][12][13]. Forty of 137 patients died during study period.…”

Section: Resultsmentioning

confidence: 99%

“…Even one course of CT worsens the nutritional status of the patients in geriatric GI malignancies (12). Impact of nutritional status in the era of FOLFOX/FIRI-based chemotherapy was also studied and it was found that the well-nourished patients at first 6 months may predict a good response to therapy and fewer adverse events in FOLFOX/FIRI chemotherapy (13).…”

Section: Introductionmentioning

confidence: 99%

Does nutritional status affect treatment tolarability, response, and survival in metastatic colorectal cancer patients? Results of prospective multicenter study.

Karabulut

Doğan

Afşar

et al. 2020

JCO

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70 Background: The efficacy and tolerability of modern cytotoxic chemotherapy regimens used in malnourished metastatic colorectal cancer patients is uncertain. The aim of this study was to investigate the effect of malnutrition on efficacy and tolerability of cytotoxic chemotherapy and overall survival in mCRC patients. Methods: In this multicenter study, demographic, oncologic and nutritional data were collected prospectively from mCRC patients. Nutritional status were evaluated on the basis of NRI, BMI and WL before the first chemotherapy, after the first and second chemotherapy. To determine the inter-treatment weight loss toxicity assessment was included to theese parameters after each chemotherapy. NRIs were examined in 3 categories as ‘no malnutrition’ (NRI >97.5), ‘moderate malnutrition’ (97.5 ≥ NRI ≥83.5) or ‘severe malnutrition’ (NRI <83.5). Response to treatment and drug-induced toxicities were assessed based on RECIST 1.1 and CTCAE version 4.0 respectively. Results: 137 mCRC patients were prospectively included. Median age was 48 (range 18-83). Primary location was colon in 66% of patients, 84% of them source was left colon. Malnutrition was detected in 39% of the cases. Response rate to treatment was 24 %. Moderate / severe malnutrition was associated with multipl site of metastases, WHO PS of 1, over the median value of CEA/CA 19-9 levels (p=0.003, p=0.03, p<0.001, and p=0.02; respectively). Hypoalbuminemia and moderate/severe malnutrition were associated with all types of toxicity (p<0.001 and p<0.001). Moderate/severe malnutrition was associated with thrombocytopenia, and diarrhea following chemotherapy predominately, (p=0.02 and p=0.04; respectively). In moderate/severe malnutrition group median overall survival was prominently shorter than those with no malnutrition [6.6 moths (95 %CI, 5.6-7.6) vs 11.9 moths (95 % CI, 11.1-12.7) respectively, p<0.001]. Conclusions: Our study showed that moderate/severe malnutrition in mCRC patients was associated with decreased overall survival and increased chemotherapy toxicity.

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The effect of chemotherapy on nutritional status and weakness in geriatric gastrointestinal system cancer patients

Cited by 24 publications

References 24 publications

The Effect Of Chemotherapy On Malnutrition In Geriatric Group With Metastatic Colorectal Cancer

The Effect Of Chemotherapy On Malnutrition In Geriatric Group With Metastatic Colorectal Cancer

Evaluation of sarcopenia, sarcopenic obesity, and phase angle in geriatric gastrointestinal cancer patients: before and after chemotherapy

Does nutritional status affect treatment tolarability, response, and survival in metastatic colorectal cancer patients? Results of prospective multicenter study.

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