The effect of chlorhexidine gluconate irrigation on the root canal flora of freshly extracted necrotic teeth

Bacteriologic investigation of the effects of sodium hypochlorite and chlorhexidine during the endodontic treatment of teeth with apical periodontitis

“…[2][3][4] Sodium hypochlorite (NaOCl) remains the most used irrigant due to its potent antimicrobial activity and lubricant and tissue-dissolving ability. 5 More recently, chlorhexidine has emerged as a potential irrigant, 6 given its broad-spectrum efficacy against oral bacteria. 7,8 In vivo and ex vivo studies comparing the antimicrobial effectiveness of chlorhexidine and NaOCl when used as irrigants during chemomechanical preparation have demonstrated conflicting results.…”

The antimicrobial effects of root canal irrigation and medication

“…Chlorhexidine possesses adequate antimicrobial properties for an endodontic irrigant with 0.2% chlorhexidine, as shown by significant reduction in colony-forming units. 29,30 Sen et al 31 found chlorhexidine to be effective against C albicans. It has also been shown to be effective in eliminating bacteria penetrate up to 500 m within dentinal tubules.…”

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“…In the present study, all the tested solutions significantly reduced the microorganisms in oral cavity in a period of 3 minutes whereas 0.2% CHX didn't showed any reduction. CHX is a broad spectrum antimicrobial agent 11 , that can be used effectively as mouthwash, an irrigant [12][13][14][15][16][17] , disinfect the dentinal tubules [18][19][20] , and be absorbed into the dentin. Several researchers have pointed out the potential advantages of CHX as an antimicrobial medicament in endodontic therapy.…”