The effect of chronic l- carnitine l-tartarate supplementation on glucose and lactate concentration and aerobic capacity

Izadi, Morteza; Maryam, Cheraghydocheshmeh; Davood, Khorshidi; Kiani, Farhoush

doi:10.1016/j.sbspro.2009.01.476

Cited by 3 publications

(9 citation statements)

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“…These results were in line with research by Arazi et al (2013) and Noorshahi and colleagues (2009). However, similar results were not observed by Eizadi et al (Eizadi et al, 2009;Mojtaba et al, 2009). This may be due to long-term ingestion of L-carnitine that is likely to be associated with adaptations.…”

Section: Discussionsupporting

confidence: 64%

“…Stephens et al (2007) stated that L-carnitine supplementation leads to reduced muscle glycolysis, increased fat oxidation, increased blood glucose concentrations and increased time to exhaustion. After L-carnitine supplementation, Eizadi and colleagues did not find any significant change in glucose levels after exercise (Eizadi et al, 2009;Mojtaba et al, 2009). The subjects of this study were sedentary persons and, considering the effect of exercise on muscle carnitine uptake, the subjects' muscles did not absorb L-carnitine and did not get the required amount of impact on fat oxidation.…”

Section: Discussionmentioning

confidence: 65%

“…Eizadi et al (2009) investigated the Influence of short-term L-carnitine and heparin 90 minutes before exercise. The results of this study showed that short-term use of L-carnitine and heparin did not have any effect on glucose and blood lactate (Mojtaba, Maryam, Davood, & Fatemeh, 2009). Arazi and colleagues (2013) showed that short-term supplementation of L-carnitine can reduce lactate concentration after a high intensity exercise (Arazi, Rahmaninia, Azali, & Mehrtash, 2013).…”

Section: Introductionmentioning

confidence: 70%

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Effect of Acute L-Carnitine Supplementation on Blood Lactate, Glucose, Aerobic and Anaerobic Performance in Elite Male Artistic Gymnasts

Arazi

Mehrtash

2017

Baltic Journal of Sport and Health Sciences

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Background. Probably L-Carnitine can induce the increase of Pyruvate dehydrogenase activity, decrease of lactic acid production and performance improvements due to the reinforcement of long chain fatty acid oxidation and stabilize of coASH to free COA. Based on this, the aim of our study was to investigate the effects of acute L-Carnitine supplementation on blood lactate, glucose, VO 2 max and anaerobic power in elite male artistic gymnasts. Methods. Eighteen male artistic gymnasts were randomly assigned to supplementation (n = 9) or placebo (n = 9) groups. In a double blind design, subjects participated in two tests with a break of one week between them. Subjects ingested 3 grams of L-Carnitine or placebo (maltodextrin) 90 minutes before aerobic and anaerobic exercise protocols. We used a 20 m shuttle run as an aerobic exercise protocol and running based anaerobic sprint test (RAST) as an anaerobic exercise protocol. Blood samples were collected 5 minutes pre and 4 minutes post-tests for the analysis of lactate and glucose. Results. L-Carnitine group had significantly lower lactate concentration than placebo group after tests (p < .05). L-Carnitine group had significantly higher blood glucose (p < .05) compared with placebo group, too. Also VO 2 max as well as mean and maximum power in L-Carnitine group were significantly higher than those in placebo group (p < .05). Conclusions. These findings indicated that acute oral supplementation of L-Carnitine can probably induce fatigue decrease and improvement of aerobic and anaerobic performance in elite male artistic gymnasts.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 70%

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Effect of Acute L-Carnitine Supplementation on Blood Lactate, Glucose, Aerobic and Anaerobic Performance in Elite Male Artistic Gymnasts

Arazi

Mehrtash

2017

Baltic Journal of Sport and Health Sciences

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“…These findings are in accordance with the results found by Noorshahi and Ebrahimi in 2009. 9 But similar results were not observed in a research by Izadi et al 8,12 which can be due to long-term consumption of L-carnitine, excess excretion via urine and possible adjustments. 13 Wächter et al reported that long-term L-carnitine supplementation had no impact on VO 2 max.…”

Section: Discussionmentioning

confidence: 65%

“…In fact, the consumption of chronic L-carnitine did not improve the performance and the aforementioned factors. 8 Despite these findings, the effect of acute consumption of L-carnitine on acid lactic, glucose and oxygen saturation followed by an aerobic exercise test (Bruce test) is not still clear. Therefore, our aim was to assess the role of acute L-carnitine administration on lactate, glucose, oxygen saturation and VO 2 max in active young men.…”

Section: Introductionmentioning

confidence: 99%

Acute Effect of L-Carnitine Supplements on Lactate, Glucose, Saturated Oxygen and VO2max Variations in Young Males

Kashef¹,

Saei²

2017

Int J Basic Sci Med

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Introduction: L-carnitine may improve athlete's performance by increasing lipids oxidation. The goal of the present study was to assess the acute impact of L-carnitine supplements on lactate, glucose, saturated oxygen and VO 2 max levels in young men. Methods: Ten young males completed 2 sessions of exhausting exercise (Bruce test). In the first session, the participants consumed placebo and in the second session, they consumed 3 g of L-carnitine 90 minutes before the test. The 2 sessions were 1-week apart. Then dependent parameters were measured. Results: A significant difference was detected in VO 2 max and lactate between the placebo and supplement groups (P < 0.05) but the difference between glucose, saturated oxygen and heart rate was not statistically significant (P > 0.05) between the 2 groups. Conclusion: The present study showed that L-carnitine supplementation before exercise decreases lactate and increases VO 2 max in young men.

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The effects of L-carnitine supplementation on glycemic markers in adults: A systematic review and dose-response meta-analysis

et al. 2023

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Background and aimsHyperglycemia and insulin resistance are concerns today worldwide. Recently, L-carnitine supplementation has been suggested as an effective adjunctive therapy in glycemic control. Therefore, it seems important to investigate its effect on glycemic markers.MethodsPubMed, Scopus, Web of Science, and the Cochrane databases were searched in October 2022 for prospective studies on the effects of L-carnitine supplementation on glycemic markers. Inclusion criteria included adult participants and taking oral L-carnitine supplements for at least seven days. The pooled weighted mean difference (WMD) was calculated using a random-effects model.ResultsWe included the 41 randomized controlled trials (RCTs) (n = 2900) with 44 effect sizes in this study. In the pooled analysis; L-carnitine supplementation had a significant effect on fasting blood glucose (FBG) (mg/dl) [WMD = −3.22 mg/dl; 95% CI, −5.21 to −1.23; p = 0.002; I2 = 88.6%, p < 0.001], hemoglobin A1c (HbA1c) (%) [WMD = −0.27%; 95% CI, −0.47 to −0.07; p = 0.007; I2 = 90.1%, p < 0.001] and homeostasis model assessment-estimate insulin resistance (HOMA-IR) [WMD = −0.73; 95% CI, −1.21 to −0.25; p = 0.003; I2 = 98.2%, p < 0.001] in the intervention compared to the control group. L-carnitine supplementation had a reducing effect on baseline FBG ≥100 mg/dl, trial duration ≥12 weeks, intervention dose ≥2 g/day, participants with overweight and obesity (baseline BMI 25–29.9 and >30 kg/m2), and diabetic patients. Also, L-carnitine significantly affected insulin (pmol/l), HOMA-IR (%), and HbA1c (%) in trial duration ≥12 weeks, intervention dose ≥2 g/day, and participants with obesity (baseline BMI >30 kg/m2). It also had a reducing effect on HOMA-IR in diabetic patients, non-diabetic patients, and just diabetic patients for insulin, and HbA1c. There was a significant nonlinear relationship between the duration of intervention and changes in FBG, HbA1c, and HOMA-IR. In addition, there was a significant nonlinear relationship between dose (≥2 g/day) and changes in insulin, as well as a significant linear relationship between the duration (weeks) (coefficients = −16.45, p = 0.004) of intervention and changes in HbA1C.ConclusionsL-carnitine could reduce the levels of FBG, HbA1c, and HOMA-IR.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022358692.

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The effect of chronic l- carnitine l-tartarate supplementation on glucose and lactate concentration and aerobic capacity

Cited by 3 publications

References 14 publications

Effect of Acute L-Carnitine Supplementation on Blood Lactate, Glucose, Aerobic and Anaerobic Performance in Elite Male Artistic Gymnasts

Effect of Acute L-Carnitine Supplementation on Blood Lactate, Glucose, Aerobic and Anaerobic Performance in Elite Male Artistic Gymnasts

Acute Effect of L-Carnitine Supplements on Lactate, Glucose, Saturated Oxygen and VO2max Variations in Young Males

The effects of L-carnitine supplementation on glycemic markers in adults: A systematic review and dose-response meta-analysis

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