2008
DOI: 10.2478/s11687-008-0013-4
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The effect of chronic lead acetate trihydrate intoxication in Wistar rats on experimental Ascaris suum infestation and immunity

Abstract: SummarySPF male Wistar rats were exposed for four months to lead acetate trihydrate present in drinking water (100 mg/l) and subsequently infested with 1000 ± 100 infective A. suum eggs. Metabolic activity of phagocytes and proliferative activity of T-lymphocytes were investigated on Day 4 and 8 after A. suum eggs infestation (Day 130 and 134 of lead acetate trihydrate exposition). The results demonstrated that treatment with lead acetate trihydrate led to increased susceptibility to infestation, manifested by… Show more

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Cited by 2 publications
(1 citation statement)
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“…Pb-induced lipid peroxidation of cellular membranes has been demonstrated to play a critical role in the oxidative damage of liver [12] . Pb may produce serious immunotoxicity to phagocytic activity as well as cellular and humoral immunity, resulting in increased host susceptibility to infection, or tumorigenesis [13] [15] . One of the major mechanisms concerning the toxicity of Pb is attributed to its ability to generate reactive oxygen species (ROS), which results in oxidative stress [16] , [17] .…”
Section: Introductionmentioning
confidence: 99%
“…Pb-induced lipid peroxidation of cellular membranes has been demonstrated to play a critical role in the oxidative damage of liver [12] . Pb may produce serious immunotoxicity to phagocytic activity as well as cellular and humoral immunity, resulting in increased host susceptibility to infection, or tumorigenesis [13] [15] . One of the major mechanisms concerning the toxicity of Pb is attributed to its ability to generate reactive oxygen species (ROS), which results in oxidative stress [16] , [17] .…”
Section: Introductionmentioning
confidence: 99%