“…Several studies of the biomarkers of endothelial dysfunction have been done in patients with diabetes mellitus or insulin resistance. Although most of them have demonstrated an increased concentration of E-selectin, P-selectin, ICAM-1 and VCAM-1, there is a broad heterogeneity in the results; mainly in regard to which factor is more highly altered [2,7,[9][10][11][12]. Furthermore, the results in patients with impaired glucose tolerance are discordant [8,12] and some studies have described, in the general population, an increased risk of diabetes mellitus in people with higher biomarkers of endothelial dysfunction [2,13,29,30].…”