The effect of cingulate lesions on social behaviour and emotion

Hadland, K. A.; Rushworth, Matthew F. S.; Gaffan, David; Passingham, Richard E.

doi:10.1016/s0028-3932(02)00325-1

Cited by 206 publications

(135 citation statements)

References 64 publications

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“…Various studies have implicated the ACC in motivation (Bush, Lu, & Posner, 2000;Bush et al, 2002;Devinsky et al, 1995;Hadland, Rushworth, Gaffan, & Passingham, 2003a), emotion and social behavior (Bush et al, 2000;Eisenberger et al, 2003;Hadland, Rushworth, Gaffan, & Passingham, 2003b), and response selection (Hadland et al, 2003a;Paus, Petrides, Evans, & Meyer, 1993;Rushworth, Hadland, & Passingham, 2003;Walton, Bannerman, Alterescu, & Rushworth, 2003). Motivational aspects of pain are those that pertain to desires, urges, or impulses to avoid or terminate a painful experience (Craig, 2003;Sewards & Sewards, 2002).…”

Section: Vicarious Pain As a Motivational-affective Representationmentioning

confidence: 99%

Vicarious responses to pain in anterior cingulate cortex: Is empathy a multisensory issue?

Morrison

Lloyd

Pellegrino

et al. 2004

Cognitive, Affective, & Behavioral Neuroscience

437

261

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Results obtained with functional magnetic resonance imaging show that both feeling a moderately painful pinprick stimulus to the fingertips and witnessing another person's hand undergo similar stimulation are associated with common activity in a pain-related area in the right dorsal anterior cingulate cortex (ACC). Common activity in response to noxious tactile and visual stimulation was restricted to the right inferior Brodmann's area 24b. These results suggest a shared neural substrate for felt and seen pain for aversive ecological events happening to strangers and in the absence of overt symbolic cues. In contrast to ACC 24b, the primary somatosensory cortex showed significant activations in response to both noxious and innocuous tactile, but not visual, stimuli. The different response patterns in the two areas are consistent with the ACC's role in coding the motivational-affective dimension of pain, which is associated with the preparation of behavioral responses to aversive events.

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Section: Vicarious Pain As a Motivational-affective Representationmentioning

confidence: 99%

Vicarious responses to pain in anterior cingulate cortex: Is empathy a multisensory issue?

Morrison

Lloyd

Pellegrino

et al. 2004

Cognitive, Affective, & Behavioral Neuroscience

437

261

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“…In all subjects, the call emitted at the end of the conditioning process was a prolonged coo. Interpretation of the effects of cingulate damage remains uncertain, given that cingulate lesions affect the overall social interaction with familiar conspecifics [33].…”

Section: Forebrain Mechanisms Of Cry Productionmentioning

confidence: 99%

Neural circuits underlying crying and cry responding in mammals

Newman

2007

Behavioural Brain Research

182

132

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Crying is a universal vocalization in human infants, as well as in the infants of other mammals. Little is known about the neural structures underlying cry production, or the circuitry that mediates a caregiver's response to cry sounds. In this review, the specific structures known or suspected to be involved in this circuit are identified, along with neurochemical systems and hormones for which evidence suggests a role in responding to infants and infant cries. In addition, evidence that crying elicits parental responses in different mammals is presented. An argument is made for including 'crying' as a functional category in the vocal repertoire of all mammalian infants (and the adults of some species). The prevailing neural model for crying production considers forebrain structures to be dispensable. However, evidence for the anterior cingulate gyrus in cry production, and this structure along with the amygdala and some other forebrain areas in responding to cries is presented.

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“…In monkeys, lesions to the ACC (that include both dorsal and ventral regions) eliminate the production of isolation calls, a form of distress vocalization intended to re-establish contact with members of the social group after social separation (11,12). Conversely, stimulation of the ACC can trigger similar vocalizations (13,14), suggesting a critical role for the ACC in the distress of being separated from others.…”

mentioning

confidence: 99%

Variation in the μ-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection

Way

Taylor

Eisenberger

2009

Proc. Natl. Acad. Sci. U.S.A.

241

195

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Scientific understanding of social pain-the hurt feelings resulting from social rejection, separation, or loss-has been facilitated by the hypothesis that such feelings arise, in part, from some of the same neural and neurochemical systems that generate the unpleasant feelings resulting from physical pain. Accordingly, in animals, the painkiller morphine not only alleviates the distress of physical pain, but also the distress of social separation. Because morphine acts on the -opioid receptor, we examined whether variation in the -opioid receptor gene (OPRM1), as measured by the functional A118G polymorphism, was associated with individual differences in rejection sensitivity. Participants (n ‫؍‬ 122) completed a self-report inventory of dispositional sensitivity to social rejection and a subsample (n ‫؍‬ 31) completed a functional MRI session in which they were rejected from an online ball-tossing game played with two supposed others. The A118G polymorphism was associated with dispositional sensitivity to rejection in the entire sample and in the fMRI subsample. Consistent with these results, G allele carriers showed greater reactivity to social rejection in neural regions previously shown to be involved in processing social pain as well as the unpleasantness of physical pain, particularly the dorsal anterior cingulate cortex (dACC) and anterior insula. Furthermore, dACC activity mediated the relationship between the A118G polymorphism and dispositional sensitivity to rejection, suggesting that this is a critical site for -opioid-related influence on social pain. Taken together, these data suggest that the A118G polymorphism specifically, and the -opioid receptor more generally, are involved in social pain in addition to physical pain.anterior cingulate ͉ brain ͉ exclusion ͉ genetic ͉ social pain

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The effect of cingulate lesions on social behaviour and emotion

Cited by 206 publications

References 64 publications

Vicarious responses to pain in anterior cingulate cortex: Is empathy a multisensory issue?

Vicarious responses to pain in anterior cingulate cortex: Is empathy a multisensory issue?

Neural circuits underlying crying and cry responding in mammals

Variation in the μ-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection

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