The effect of contrast media on CT measures of bone mineral density: a systematic review

Kutleša, Zvonimir; Jerković, Kristian; Ordulj, Ivan; Mršić, Danijela Budimir

doi:10.1007/s00256-022-04222-2

Cited by 12 publications

(3 citation statements)

References 26 publications

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“…An increase in HU of the trabecular part of L4 between the native and both post-contrast phases was nearly 12%. Thus, we confirmed our hypothesis that the application of iodine contrast falsely increases HU of lumbar spine, as it was found infmost investigations conducted on lumbar spine, presenting a similar percent of BMD increase (17). The arterial phase was more heterogeneous, compared to the venous phase, in which we noticed the stabilization of the increase.…”

Section: Methods Of Measuring the Trabecular Bone Attenuation Of The ...supporting

confidence: 91%

Povezanost CT-om procijenjene mineralne gustoće lumbalne kralježnice i masne infiltracije mišića psoasa u pacijenata mlađe i srednje životne dobi

Bolčić,

Budimir Mršić,

Ordulj

2023

Hrvat. čas. zdr. znan.

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Aims: Age-related changes of bones and skeletal muscles were investigated in previous studies. The aim of our study was to determine the possible association of CT-estimated lumbar spine bone density and psoas major muscle changes in a young and middle-aged population, in whom the age-related changes are not considerably advanced. We also investigated to which extent the iodine contrast affected bone and muscle attenuation. Methods: Baseline and CT imaging data of patients aged 18 to 49 years, who underwent a multiphasic abdominopelvic CT exam at the University Hospital Split from July to December 2021, were retrospectively retrieved. CT attenuation values, Hounsfield Units (HU), of lumbar spine and psoas major muscle were measured at the level of L4 on native (precontrast), arterial and venous postcontrast scans.Results: The mean age of 113 included patients was 40.61 years, 51.33% were men. CT attenuation values of lumbar spine and psoas major muscle correlated. The highest correlation was found between age and L4, while the correlation between age and psoas muscle was somewhat weaker. No significant differences were observed between the sexes, except higher L4 HU in women. The application of iodine contrast significantly increased HU, with a mean increase of nearly 12% at lumbar spine and 18-26% at psoas muscle.Conclusion: CT attenuation values of lumbar spine and psoas major muscle correlate in young and middle-aged population. Age-related changes were somewhat stronger in bones than in muscles. Iodine contrastysignificantly increases the HU of both bone and muscle.

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Section: Methods Of Measuring the Trabecular Bone Attenuation Of The ...supporting

confidence: 91%

Povezanost CT-om procijenjene mineralne gustoće lumbalne kralježnice i masne infiltracije mišića psoasa u pacijenata mlađe i srednje životne dobi

Bolčić,

Budimir Mršić,

Ordulj

2023

Hrvat. čas. zdr. znan.

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“…The authors concluded that for the purposes of opportunistic osteoporosis screening, contrast-enhanced abdominopelvic CT examinations are relatively equivalent to unenhanced CT and thus, they can be used to assess femoral neck BMD. In a recent review article, Kutleša et al [ 15 ] pointed at possible effects of the administration of iodine-containing contrast agents on BMD estimated on CT. This review also assessed studies that used both CT measurement via volumetric quantitative BMD and CT attenuation in Hounsfield units.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Contrast Agent on Bone Mineral Density Measurement in the Spine and Hip Using QCT-Conversion Factor Recommendation

Jäckle

Lüken

Roch

et al. 2023

JCM

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Background: Osteoporosis causes an increased fracture risk. Clinically, osteoporosis is diagnosed late, usually after the first fracture occurs. This emphasizes the need for an early diagnosis of osteoporosis. However, computed tomography (CT) as routinely used for polytrauma scans cannot be used in the form of quantitative computed tomography (QCT) diagnosis because QCT can only be applied natively, i.e., without any contrast agent application. Here, we tested whether and how contrast agent application could be used for bone densitometry measurements. Methods: Bone mineral density (BMD) was determined by QCT in the spine region of patients with and without the contrast agent Imeron 350. Corresponding scans were performed in the hip region to evaluate possible location-specific differences. Results: Measurements with and without contrast agent administration between spine and hip bones indicate that the corresponding BMD values were reproducibly different between spine and hips, indicating that Imeron 350 application has a location-specific effect. We determined location-specific conversion factors that allow us then to determine the BMD values relevant for osteoporosis diagnosis. Conclusions: Results show that contrast administration cannot be used directly for CT diagnostics because the agent significantly alters BMD values. However, location-specific conversion factors can be established, which are likely to depend on additional parameters such as the weight and corresponding BMI of the patient.

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“…Knowing these effects can help interpret CT measurements. 51 The potential benefit of an automated osteoporosis screening combined with lung cancer or other screening would be substantial for patient care, especially given the decline of DEXA utilization. 42,52 Muscle and Fat CT can also be used to evaluate adipose tissue quantity, quality, and distribution.…”

Section: Computed Tomography Bonementioning

confidence: 99%

Biomarkers of Body Composition

Chang,

Lenchik,

Blankemeier

et al. 2024

Semin Musculoskelet Radiol

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The importance and impact of imaging biomarkers has been increasing over the past few decades. We review the relevant clinical and imaging terminology needed to understand the clinical and research applications of body composition. Imaging biomarkers of bone, muscle, and fat tissues obtained with dual-energy X-ray absorptiometry, computed tomography, magnetic resonance imaging, and ultrasonography are described.

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The effect of contrast media on CT measures of bone mineral density: a systematic review

Cited by 12 publications

References 26 publications

Povezanost CT-om procijenjene mineralne gustoće lumbalne kralježnice i masne infiltracije mišića psoasa u pacijenata mlađe i srednje životne dobi

Povezanost CT-om procijenjene mineralne gustoće lumbalne kralježnice i masne infiltracije mišića psoasa u pacijenata mlađe i srednje životne dobi

Effect of a Contrast Agent on Bone Mineral Density Measurement in the Spine and Hip Using QCT-Conversion Factor Recommendation

Biomarkers of Body Composition

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