The effect of corticosteroid and cyclosporin A on murine corneal allograft rejection

Abstract

The detection of Th1 cytokines in the cornea but not the serum of mice at the time of allograft rejection is in accordance with the finding of long-lasting dose-dependent immunosuppression of topical steroids and the inefficacy of short-term systemic CsA and corticosteroids.

Influence of combined treatment of low dose rapamycin and cyclosporin A on corneal allograft survival

“…Both Rapa and CsA have been studied independently as immunosuppressive agents in experimental keratoplasty [26,27]. A consistent beneficial effect of Rapa monotherapy in corneal allograft survival has been previously reported [12,27].…”

Effects of a selective glucocorticoid receptor agonist on experimental keratoplasty

“…Similar findings were reported using "conventional" prednisolone treatment in an experimental keratoplasty model. All corneal grafts remained clear during a treatment course of 80 days but subsequently were rejected following cessation of steroid eye drop application [18]. Interestingly, the same study revealed that topical steroid treatment was even superior to systemic treatment, probably indicating that local immunoregulatory events play a dominant role in corneal graft rejection.…”

Contribution of lymphatic drainage system in corneal allograft rejection in mice

“…These cells may migrate from the iris via the uveoscleral pathway and reach the regional lymph nodes, whereupon they stimulate clonal expansion of antigen-specific T cells. It has previously been shown that IFN-γ positive cells are present in corneal grafts 2 weeks and 4 weeks after allogeneic transplantation [18,24]. This could represent a reaction to the antigen presented to the immune system by the antigen-presenting cells such as the above-mentioned macrophages.…”