The Effect of CPAP in Normalizing Daytime Sleepiness, Quality of Life, and Neurocognitive Function in Patients with Moderate to Severe OSA

Abstract

Our study suggests that a greater percentage of patients achieve normal functioning with longer nightly CPAP duration of use, but a substantial proportion of patients will not normalize neurobehavioral responses despite seemingly adequate CPAP use. It is thus crucial to adequately assess patients after CPAP therapy and seek alternate etiologies and treatments for any residual abnormalities.

Long-Term Effectiveness and Safety of Maxillomandibular Advancement for Treatment of Obstructive Sleep Apnea

“…15 Signifi cant improvements in objective and subjective sleepiness, blood pressure (BP), QOL, and neurocognitive function are noted with CPAP use. [15][16][17] Furthermore, treatment of severe OSA with CPAP reduces the risk of cardiovascular events.…”

Beneficial Effects of Long-Term CPAP Treatment on Sleep Quality and Blood Pressure in Adherent Subjects With Obstructive Sleep Apnea

“…In other previous studies, a dose-response effect on ESS scores was documented after 3 months of CPAP treatment. 22,23 In another earlier study, Pietrzyk et al 24 found a beneficial effect of 1 y of CPAP treatment on excessive daytime sleepiness in subjects with OSA. Our findings were compatible with previous studies and also supported the dose-dependent response of excessive daytime sleepiness to long-term CPAP treatment.…”

New and Unconventional Treatments for Obstructive Sleep Apnea

“…sleepiness [3], and snoring, but a reduction in hypertension [4], car accidents [5,6] and mortality [7] is also seen in patients compliant with therapy. In addition, CPAP has shown itself to be a cost effective treatment option compared to lifestyle measures [8] There is a wide range of CPAP compliance rates reported in the literature, varying by study design and definitions of compliance, with values ranging from 46 % to 85 % [9,10].…”