The effect of cumin supplementation on metabolic profiles in patients with metabolic syndrome: A randomized, triple blind, placebo‐controlled clinical trial

Abstract

Metabolic syndrome (MetS) is a cluster of interconnected serious disorders, which is a major health problem whose prevalence is increasing. Oxidative stress and inflammation contribute to the disease pathogenesis and its complications. The present study aimed to investigate the effect of Cuminum cyminum L. (which has antioxidant and anti-inflammatory properties) essential oil (CuEO) supplementation on inflammatory and antioxidant status in patients with MetS. In this clinical trial, 56 patients with MetS aged 18-60 years received either 75-mg CuEO or placebo soft gel, thrice daily, for 8 weeks. Data on anthropometric parameters, food consumption, tumor necrosis factor alpha, high-sensitivity C-reactive protein, superoxide dismutase (SOD), glutathione peroxidase, catalase, total antioxidant capacity (TAC), and malondialdehyde (MDA) were assessed at the beginning and at the end of the study. Compared with the placebo group, CuEO increased SOD (149.17; 95% CI, [67.93, 230.42]), TAC (0.24; 95% CI, [0.09, 0.38]) and decreased MDA (−0.36; 95% CI, [−0.66, 0.06]),(p < 0.01). In within-group analysis, CuEO led to 13.3% decrease in MDA and 6.7% increase in TAC levels (p < 0.04). The results indicated that CuEO supplementation can improve some antioxidative indices, as SOD and TAC, while decreasing MDA in patients with MetS.

A review on traditional uses, phytochemistry, pharmacology, and clinical research of dietary spice Cuminum cyminum L.

“…Metabolic syndrome (MS) is characterized by the co-existence of multiple risk factors like abdominal obesity, increased fasting glucose content, hypertriglyceridemia, low high-density lipoprotein cholesterol level, and enhanced blood pressure. The patients suffering from MS are five times more prone to the pathogenesis of hyperglycemia and atherosclerotic cardiovascular disease(Morovati et al, 2019). In this regard,Morovati et al (2019) carried out a randomized, triple-blind, placebo-controlled clinical trial to demonstrate the cumin role on MS patients.…”

Effects of cumin (Cuminum cyminum L.) essential oil supplementation on metabolic syndrome components: A randomized, triple‐blind, placebo‐controlled clinical trial

“…In both groups, the energy and mineral intakes did not have any significant differences at the end of the study ( p > .05; Table ). Macronutrients and dietary fiber intakes were not different between two groups either (the related results are given in another published article; Morovati, Pourghassem Gargari, Sarbakhsh, Azari, & Lotfi‐Dizaji, ).…”

“…It has been suggested cuminaldehyde causes upregulation of LDL-C receptors to remove LDL-C from the blood and reduces the production of oxidized low-density lipoprotein (Andallu & Ramya, 2007). In addition, CuEO is known to have antioxidant and lipid peroxidation inhibitory properties (Moghadam, 2016;Morovati et al, 2019). et al, 2013).…”

The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood

“…Cumin essential oil supplementation enhanced some antioxidative indices, as superoxide dismutase and total antioxidant capacity in patients with metabolic syndrome [235]. Based on a randomized crossover trial, pomegranate juice consumption for eight weeks in hemodialysis patients resulted in beneficial effects on blood pressure, oxidative stress, inflammation, and serum lipoprotein cholesterol [236].…”