The effect of cutaneous mast cell degranulation on sensitivity to heat

Drummond, Peter D.

doi:10.1007/s00011-004-1263-3

Cited by 21 publications

(12 citation statements)

References 36 publications

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“…It is possible that TNF-α released from mast cell granules have rapid effect on nociceptors that contribute to immediate protective nociceptive responses. These findings support an earlier observation that injection of c48/80 into the forearms of young male volunteers caused significant changes in pain sensitivity in the skin surrounding the sites of administration [29]. …”

Section: Mast Cell Activation Provokes Experimental Thermal and Mesupporting

confidence: 91%

Mast cells: Versatile gatekeepers of pain

Chatterjea¹,

Martinov²

2015

Molecular Immunology

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Mast cells are important first responders in protective pain responses that provoke withdrawal from intense, noxious environmental stimuli, in part because of their sentinel location in tissue-environment interfaces. In chronic pain disorders, the proximity of mast cells to nerves potentiates critical molecular cross-talk between these two cell types that results in their synergistic contribution to the initiation and propagation of long-term changes in pain responses via intricate signal networks of neurotransmitters, cytokines and adhesion molecules. Both in rodent models of inflammatory pain and chronic pain disorders, as well as in increasing evidence from the clinic, it is abundantly clear that understanding the mast cell-mediated mechanisms underlying protective and maladaptive pain cascades will lead to improved understanding of mast cell biology as well as the development of novel, targeted therapies for the treatment and management of debilitating pain conditions.

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Section: Mast Cell Activation Provokes Experimental Thermal and Mesupporting

confidence: 91%

Mast cells: Versatile gatekeepers of pain

Chatterjea¹,

Martinov²

2015

Molecular Immunology

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“…bladder/colon nociceptors) have higher chemosensitivity than cutaneous nociceptors and that the level of MC-related activation of somatic nociceptors is not sufficient to activate dorsal horn neurons. Of note is a study showing that 48/80 – evoked cutaneous MC degranulation in humans does not lead to overt pain (Drummond, 2004). Such a differential responsiveness of somatic and visceral nociceptive afferents to MC mediators might explain the higher prevalence of headache and visceral pain in conditions that are associated with systemic MC degranulation.…”

Section: Discussionmentioning

confidence: 99%

Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity

Levy

Kainz

Burstein

et al. 2012

Brain, Behavior, and Immunity

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Mast cells (MCs) are tissue resident immune cells that participate in a variety of allergic and other inflammatory conditions. In most tissues, MCs are found in close proximity to nerve endings of primary afferent neurons that signal pain (i.e. nociceptors). Activation of MCs causes the release of a plethora of mediators that can activate these nociceptors and promote pain. Although MCs are ubiquitous, conditions associated with systemic MC activation give rise primarily to two major types of pain, headache and visceral pain. In this study we therefore examined the extent to which systemic MC degranulation induced by intraperitoneal administration of the MC secretagogue compound 48/80 activates pain pathways that originate in different parts of the body and studied whether this action can lead to development of behavioral pain hypersensitivity. Using c-fos expression as a marker of central nervous system neural activation, we found that intraperitoneal administration of 48/80 leads to the activation of dorsal horn neurons at two specific levels of the spinal cord; one responsible for processing cranial pain, at the medullary/C2 level, and one that processes pelvic visceral pain, at the caudal lumbar/rostral sacral level (L6-S2). Using behavioral sensory testing, we found that this nociceptive activation is associated with development of widespread tactile pain hypersensitivity within and outside the body regions corresponding to the activated spinal levels. Our data provide a neural basis for understanding the primacy of headache and visceral pain in conditions that involve systemic MC degranulation. Our data further suggest that MC activation may lead to widespread tactile pain hypersensitivity.

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“…2 Alternatively, differential density of nerve fibers expressing the capsaicin-sensitive vallinoid receptor, TRPV1, 13 could underlie the differences, as could differential prevalence of dermal mast cells (or other cells in skin) expressing TRPV1 receptors. 5,7,10 The task, then, is to determine which physiological mechanisms are associated with the individual components responsible for sex and location differences, or with individual differences between responders.…”

Section: Discussionmentioning

confidence: 99%