The effect of cycle stage and plasma progesterone level on the induction of multiple ovulations in heifers

Sreenan, J.M.; Gosling, James P.

doi:10.1530/jrf.0.0500367

Cited by 33 publications

(5 citation statements)

References 9 publications

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“…The finding that progesterone levels at the initiation of PMSG treatment and thereafter are not correlated with the number of preovulatory follicles agrees with previous reports on superovulation with PMSG and with FSH ( Screenan and Gosling, 1977;Jensen et al, 1982;Tamboura et al, 1985;Lindsell et al, 1986). Contrary to this, Yadav et al (1986) observed a significant correlation between the progesterone level at the initiation of superovulation treatment with FSH and PMSG and the ovulation rate in lactating cows ( n = 6 for each group).…”

Section: Discussionsupporting

confidence: 89%

Superovulation of cows with PMSG: Variation in plasma concentrations of progesterone, oestradiol, LH, cortisol, prolactin and PMSG and in number of preovulatory follicles

Bevers

Dieleman

1987

Animal Reproduction Science

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Forty-two heifers, exhibiting normal oestrous cycles, were treated with 2500 I.U. PMSG and 2 ml prostaglandin (PG) at day 10 and 12 of the oestrous cycle, respectively. In ten heifers progesterone, oestradiol, LH, prolactin, cortisol and PMSG levels were estimated until 10 days after the initiation of superovulation. In 32 heifers the occurrence of the LH surge was determined with a rapid radioimmunoassay, and 22-30 h after the LH surge the heifers were ovariectomized. The numbers of large follicles ( > 10 mm) and ovulations on the collected ovaries were counted and the levels of progesterone, oestradiol, PMSG and LH in the peripheral blood where estimated. The sum of large follicles and ovulations was assumed to represent the number of preovulatory follicles. In 16.7% of the heifers no LH surge was detected. This failure of the LH surge after superovulation appeared not to be caused by significantly different levels of cortisol, prolactin and PMSG as compared to those of cows responding with an LH surge.There was quite some variability in the interval between the PG injection and the maximum of the LH surge. The mean interval was 43.9_+ 1.5 h (SEM; n--28). This interval PG-LH was negatively correlated with the number of preovulatory follicles (r = -0.483; P < 0.01 ). The interval between the onset of oestrus and the maximum of the LH surge was 1.96 _+ 0.54 h (n = 22).The oestradiol concentration during the preovulatory LH surge and the number of preovulatory follicles were positively correlated (r = 0.732; P < 0.01 ). Progesterone levels were significantly increased after the initiation of superovulation. There was no significant correlation between the progesterone level before or after the administration of PMSG and the number of preovulatory follicles. This number was also not correlated with the concentration of PMSG in the peripheral blood shortly after injection of PMSG or shortly after injection of PG. The results indicate that the marked variability in response to PMSG/PG superovulation is not due to variations of hormone concentrations during the stages of preovulatory follicular development.

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Section: Discussionsupporting

confidence: 89%

Superovulation of cows with PMSG: Variation in plasma concentrations of progesterone, oestradiol, LH, cortisol, prolactin and PMSG and in number of preovulatory follicles

Bevers

Dieleman

1987

Animal Reproduction Science

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“…While it seems unlikely, due to the variability in dose responses to PMSG (Land, 1970), it is possible that other doses of PMSG or other hor¬ mones might give different patterns of response. Hormone-induced ovulation rate has been shown to be affected by the dose of gonadotrophins administered and the ratio of FSH to LH activity (Bindon & Pennycuik, 1974;Sreenan & Gosling, 1977;Donaldson, 1984;Lindsell et al, 1985;Chupín et ai, 1985).…”

Section: Methodsmentioning

confidence: 99%

Characterization of genetic differences in hormone-induced ovulation rate in mice

Spearow

1988

Reproduction

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Summary. Major genetic differences in hormone-induced ovulation rate were not explained by strain differences in age at puberty, by maturation and ovulation of follicles by endogenous gonadotrophins, or by differential responses to gonadotrophins at different ages. The major genetic differences in hormone-induced ovulation rate were explained by strain differences in ovarian responsiveness to exogenous gonadotrophins.

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“…After removal of the pessary, the P 4 drop-off leads to a preovula- tory gonadotropin increase with induction of estrus and ovulation (18). In the superovulation protocols P 4 is combined with PGF2α for induction of luteolysis and gonadotropins for induction of superovulation (12) and has little effect on the ovulation rate itself (21). In this case, the cow was treated once with a PRID®alpha pessary and it became pregnant three ovulations later.…”

Section: Discussionmentioning

confidence: 99%

Abnormal multiple pregnancy with septuplets in a cow

Fischer

Hofmeister²

2013

Tierarztl Prax Ausg G

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SummaryA 5-year-old Brown Swiss cow being 8 months pregnant became recumbent and died. Postmortem examination revealed a multiple pregnancy with six normally developed fetuses and an amorphous globosus. The cow’s internal organs were displaced and compressed the lungs. Fatty liver caused by metabolic disturbances was diagnosed. A multiple pregnancy with more than two fetuses is very rare in cattle. It could be induced by treatment with exogenous hormones, but it could also be the result of genetic selection.

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The effect of cycle stage and plasma progesterone level on the induction of multiple ovulations in heifers

Cited by 33 publications

References 9 publications

Superovulation of cows with PMSG: Variation in plasma concentrations of progesterone, oestradiol, LH, cortisol, prolactin and PMSG and in number of preovulatory follicles

Superovulation of cows with PMSG: Variation in plasma concentrations of progesterone, oestradiol, LH, cortisol, prolactin and PMSG and in number of preovulatory follicles

Characterization of genetic differences in hormone-induced ovulation rate in mice

Abnormal multiple pregnancy with septuplets in a cow

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